Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7129071 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 10/31/2006 |
| 7078195 | Antibiotics AA-896 This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-Bl, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-8... | 07/18/2006 |
| 7067286 | host cells containing heterologous PKS genes for the synthesis of polykedtides Recombinant host cells of the suborder Cystobacterineae, genus Stizmatella, containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can produce epothilones at high levels are provided. ... | 06/27/2006 |
| 7022503 | Process for the stereoselective preparation of functionalized vicinal diols The present invention relates to a process for the kinetic resolution of racemic functionalized epoxides in the presence of microorganisms, crude or pure preparations thereof comprising a polypeptide having epoxide hydrolase activity. Preferred microorganisms are ye... | 04/04/2006 |
| 6921650 | Recombinant methods and materials for producing epothilone and epothilone derivatives Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera... | 07/26/2005 |
| 6653076 | Stable isotope metabolic labeling for analysis of biopolymers Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which as been labeled with a stable isotope are provided. Further, the present invention provides method f... | 11/25/2003 |
| 6506402 | Chlortetracycline-containing animal feed compositions and methods for their use The present invention provides improved chlortetracycline-containing animal feed compositions and processes and apparatuses for their preparation. In certain embodiments, raw fermentation broth comprising chlortetracycline is divided into two portions. Th... | 01/14/2003 |
| 6503727 | Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the... | 01/07/2003 |
| 6383773 | Penicillin conversion The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular, the invention defines reaction conditions under which expan... | 05/07/2002 |
| 6180360 | Process of producing ଲ-lactam antibiotics applying micro-organisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ... | 01/30/2001 |
| 5942411 | Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ... | 08/24/1999 |
| 5512454 | Enzymatic acylation of 3-hydroxymethyl cephalosporins O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an ora... | 04/30/1996 |
| 5474912 | Method for increasing production of microbial metabolites by genetic engineering Targeted gene insertion methodology can increase the production of an antimicrobial metabolite and comprises the steps of: a) identifying the gene in unaltered chromosomal DNA which encodes an enzyme that catalyzes the rate controlling step in a biosynthetic p... | 12/12/1995 |
| 5079146 | Method of protection of the carboxy groups in the chemistry of ଲ-lactam compounds The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of ଲ-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetox... | 01/07/1992 |
| 4775622 | Expression, processing and secretion of heterologous protein by yeast Yeast organisms are caused to express, process, and secrete protein that is normally heterologous to yeast and not required for its viability by transforming yeast with an expression vector containing a gene encoding heterologous protein and a signal sequ... | 10/04/1988 |
| 4410626 | Process for the production of 7-methoxycephalosporin derivatives 7-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7-methoxycephalosporin derivatives.... | 10/18/1983 |
| 4368263 | Production of cephalosporins An improved strain of Acremonium chrysogenum may be produced by submitting parent strains of Acremonium chrysogenum to protoplast fusion and nuclear fusion and selecting said improved strain from the progeny or from a mutant thereof. The improved strains ... | 01/11/1983 |
| 4332891 | Process for the production of antibiotic Cephamycin C A process for producing an antibiotic Cephamycin C which comprises cultivating a strain of Streptomyces sp. OFR 1022 in a culture medium to accumulate therein Cephamycin C and recovering said Cephamycin C.... | 06/01/1982 |
| 4256835 | Process for preparing cephamycin C A novel process for preparing cephamycin C known antibiotic being useful as a medicament and veterinary drug, characterized by cultivating Streptomyces todorominensis sp. nov. in a suitable medium and recovering cephamycin C from the fermentation broth.... | 03/17/1981 |
| 4242449 | 7-Methoxy cephalosporins and process of producing them The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R1 represents ##STR2## group or HOOC-- group, R2 represents a ... | 12/30/1980 |
| 4076588 | Antibiotic SF-1623 substance and the production thereof A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the f... | 02/28/1978 |
| 4036696 | Preparation of antibiotics by fermentation A fermentation process for preparing 7-methoxy substituted cephalosporins. The products are useful as antibiotics and exhibit activity against gram-negative and gram-positive bacteria.... | 07/19/1977 |
| 4017485 | 7-Methoxycephalosporin derivatives A novel antibiotic C-2801-X represented by the formula ##STR1## is produced by cultivating a microorganism of the genus Streptomyces. The compound is useful in the treatment of mammals, including human beings, suffering from urinary tract infections, ... | 04/12/1977 |
| 3985742 | Process for preparing 3-hydroxymethyl cephalosporins Disclosed are 7ଲ-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; ... | 10/12/1976 |
| 3977942 | Fermentation of cephamycin C Increased yields of the known and useful antibiotic cephamycin C [7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-methoxy-3-ceph em-4-carboxylic acid] are obtained by the addition of D- or DL-arginine, D- or DL-ornithine and/or one of several p... | 08/31/1976 |
| 3976546 | Cephalosporins 3-Acyloxymethylceph-3-em-4-carboxylic acids, for example cephalosporin C, are enzymically deacylated to their 3-hydroxymethyl analogues by means of esterases produced by culturing microorganisms or mutants thereof of the class Basidiomycetes, particularly... | 08/24/1976 |
| 3975235 | Process for the production of cephamycin type antibiotic substances Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-cephem-4-carbo xylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of esterase enzyme of mold fungi.... | 08/17/1976 |
| 3974035 | Process for preparing a cephamycin type antibiotic substance This invention relates to a process for preparing a cephamycin type antibiotic substance which comprises cultivating a microorganism belonging to the genus Streptomyces under aerobic conditions and a primary object of this invention is to provide a proces... | 08/10/1976 |
