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| Number | Title | Issue Date |
| 7238347 | Suicidal mutant vaccine The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmani... | 07/03/2007 |
| 7138279 | Transposon-based transformation system A transposon-based mutagenesis method for altering DNA in Sorangium and other Myxococcales host cells is provided, along with vectors and transposases for use in the method. ... | 11/21/2006 |
| 7125695 | Directed evolution of microorganisms The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention a... | 10/24/2006 |
| 6762040 | Method for increasing gene copy number in a host cell and resulting host cell The invention relates to a method for increasing the copy number of a chromosomally integrated expression cassette in a microbial strain without leaving antibiotic resistance markers behind in the strain, the necessary genetic constructs, and the strains resulting f... | 07/13/2004 |
| 6730499 | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable marker in methylotrophic yeasts. The FLD promoter sequences are stro... | 05/04/2004 |
| 6706503 | Directed evolution of microorganisms The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention a... | 03/16/2004 |
| 6548246 | Method and probes for the identification of microbial genes specifically induced during host infection The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular coding sequences or defined regions thereof may be used as ... | 04/15/2003 |
| 6261842 | Microorganism genomics, compositions and methods related thereto The present invention provides methods and compositions for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosyntheti... | 07/17/2001 |
| 6057146 | Microorganisms for the stabilization of plasmids New microorganisms with plasmids stable relative to betaine use. These new microorganisms contain (a) a hybrid plasmid with a DNA fragment that contains a genetic sequence that codes for the use of betaine and (b) a mutation in the chromosomal gene coding... | 05/02/2000 |
| 6051431 | Selection marker gene free recombinant strains: a method for obtaining them and the use of these strains The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indica... | 04/18/2000 |
| 6048694 | Bacterial positive selection vector A positive selection vector is provided for the transformation and screening of Gram positive bacteria and particularly Bacillus sp. for the presence of foreign DNA. The vector comprises a mutant gene encoding a signal peptide processing mutation. Express... | 04/11/2000 |
| 5972708 | Plasmid stabilization A system is described which utilizes a novel system of repressor titration for maintenance of a plasmid useful in gene therapy and production of a recombinant protein. The system utilizes a transformed host cell containing a plasmid including an operator ... | 10/26/1999 |
| 5919680 | Process for the production of SSC's via expandase activity on penicillin G An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing modified expandase enzyme.... | 07/06/1999 |
| 5866551 | Recombinant adero viruses comprising an inserted gene encoding apolipoprotein and their use in gene therapy for dyslipoproteinemias The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipopr... | 02/02/1999 |
| 5851804 | Chimeric kanamycin resistance gene Chimeric kanamycin resistance genes are disclosed. The chimeric genes comprise a nucleotide sequence that encodes ANT(4')-IA enzyme operably linked to a heterologous promoter and a heterologous termination sequence. Plasmids that comprise the chimeric kan... | 12/22/1998 |
| 5834233 | Method of limiting the survival of genetically engineered microorganisms in their enivronment The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably exp... | 11/10/1998 |
| 5798236 | Synthesis of quinic acid from glucose There are described methods for the synthesis of quinoid organic compounds from a renewable energy source such as glucose. The method comprises enhancing the amount of glucose equivalents introduced into the pathway, blocking the common pathway so as to a... | 08/25/1998 |
| 5627072 | Food-grade vector suitable for transforming a food-grade host cell use of said vector for transforming food-grade host cells and use of said transformed cells in biotransformation processes A food-grade vector is provided which is suitable for transforming a food-grade host cell and is incapable of replicating autonomously in the host cell due to deletion of the replicase gene.... | 05/06/1997 |
| 5610044 | Microorganisms with mannopine catabolizing ability The present invention relates to a method for enhancing colonization of desired microorganisms in a localized environment comprising introducing into said localized environment a genetically engineered microorganism comprising a gene comprising a DNA sequ... | 03/11/1997 |
| 5578474 | Process for culturing recombinant microorganisms A recombinant microorganism strain having a desired metabolic property is produced by a process which utilizes a multiple chemostat system.... | 11/26/1996 |
| 5468632 | Recombinant DNA compounds and expression vectors encoding para-nitrobenzyl esterase activity from bacillus The present invention provides isolated DNA compounds and recombinant DNA cloning and expression vectors that encode PNB esterase from Bacillus subtilis. The invention also provides host cells transformed with these vectors and a method for production of ... | 11/21/1995 |
| 5242809 | Gal operon of streptomyces A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter, P2 promoter, P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.... | 09/07/1993 |
| 5240831 | Methods and compositions for the expression of biologically active eukaryotic cytochrome P45OS in bacteria Disclosed are methods and compositions for effecting bacterial expression of eukaryotic cytochrome P450 enzymes in a biologically active form. Particular embodiments involve the expression of eukaryotic cythochrome P45017 -hydroxylase wh... | 08/31/1993 |
| 5173425 | Enhancement of naphthalene dioxygenase activity during microbial indigo production This invention relates to a process for the enhancement of naphthalene dioxygenase activity in organisms that have been transformed with DNA encoding the expression of a multiple component naphthalene dioxygenase enzyme. Cells containing the naphthalene d... | 12/22/1992 |
| 5093240 | Variant aequorin genes and process for producing variant aequorin proteins Various variants of photoprotein aequorin (pAQ440), useful for elucidating the mechanism of its luminescence and thereby extending the possibility of concrete applications of aequorin protein, and a process for producing variant aequorin proteins are prov... | 03/03/1992 |
| 4895802 | DNA strand coding for -acetolactate decarboxylase and yeast transformed with the DNA strand DNA strand having an ability in biotechnological production of -acetolactate decarboxylase is disclosed. The DNA strand is characterized in that it has a nucleotide sequence coding for a polypeptide whose amino acid sequence is substantially from A... | 01/23/1990 |
| 4800158 | Bacterial method and compositions for linalool degradation A method for degrading linalool using Pseudomonas strains is described. Also described are novel Pseudomonas putida strains which degrade linalool and in some instances geraniol and citronellol. A method for producing 6-methyl-5-heptene-2-one using certai... | 01/24/1989 |
| 4757012 | Ascorbic acid intermediates and process enzymes Recombinant plasmids containing the gene encoding 2,5-diketogluconic acid reductase are prepared and used to transform microorganisms. 2,5,DKG reductase is expressed by the microorganisms.... | 07/12/1988 |
| 4753876 | Marker genes in pseudomonad bacteria This invention discloses the use of marker genes which do not involve antibiotics for environmental tracking of microorganisms. Such marker genes include chromogenic marker genes, and marker genes that allow a cell to proliferate on media containing a sol... | 06/28/1988 |
| 4654303 | Construction of novel mutant microorganisms This invention provides novel mutant strains of microorganisms (e.g., Pseudomonas putida Biotype A) which are capable of converting substrates such as toluene, p-xylene, catechol and 4-methylcatechol to 2-hydroxymuconic semialdehyde or substituted analog ... | 03/31/1987 |
| 4593003 | Bacterial method and compositions for isoprenoid degradation A bacterial method and compositions for degrading isoprenoids using selected Pseudomonas strains, particularly strains of Pseudomonas putida, are described. Plasmid pSRQ50 in the selected Pseudomonas strains was isolated from an isoprenoid rich environmen... | 06/03/1986 |
| 4520106 | Tartrate catabolism gene DNA sequences which are capable of expressing a polypeptide with the ability to catabolize L-tartrate are incorporated into suitable vectors and used to transform both prokaryotic and eukaryotic hosts.... | 05/28/1985 |
| 4508824 | Pseudomonas degradation of hydrocarbons Selected new bacteria of the genus Pseudomonas, particularly the species Pseudomonas putida and Pseudomonas aeruginosa, which have the ability to utilize organic compounds from the generic groups aliphatic, cyclo aliphatic, aromatic and/or polynuclear aro... | 04/02/1985 |
| 4472502 | Malolactic gene DNA sequences which are capable of converting L-malate into L-lactate are incorporated into suitable vectors and used to transform both prokaryotic and eukaryotic hosts. The DNA sequences and vectors are particularly useful in conferring the ability to pe... | 09/18/1984 |
| 4259444 | Microorganisms having multiple compatible degradative energy-generating plasmids and preparation thereof Unique microorganisms have been developed by the application of genetic engineering techniques. These microorganisms contain at least two stable (compatible) energy-generating plasmids, these plasmids specifying separate degradative pathways. The techniqu... | 03/31/1981 |
