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| Number | Title | Issue Date |
| 8163558 | Plasmids for transforming bacteria of the spp. genus, and transformation method The present invention discloses functional plasmids in bacteria of the Acidithiobacillus genus, such as the Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Acidithiobacillus caldus species. And a method to successfully transfor... | 04/24/2012 |
| 7501282 | Plasmid autonomously replicable in family A gene isolated from a microorganism selected from the group consisting of Pantoea bacteria, Erwinia bacteria, and Enterobacter bacteria, and encoding a Rep protein or a homologue thereof is described. A plasmid containing the gene which is auto... | 03/10/2009 |
| 7425449 | Site specific integration vectors and methods for using the same Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many embodiments the bacteriophage that is the source of these elements... | 09/16/2008 |
| 7416859 | cloning and expression vectors A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors and particularly in shuttle vectors for the expression of heterol... | 08/26/2008 |
| 7393679 | Whole cell catalyst A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process for the production of this catalysts and for the production of... | 07/01/2008 |
| 7361496 | Rescue of mumps virus from cDNA This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the mumps virus... | 04/22/2008 |
| 7358083 | Food-grade cloning vector and their use in lactic acid bacteria Novel food-grade cloning vectors comprising a nonsense mutation suppressor-encoding gene, which vector, when it is present in a lactic acid bacterial strain, permits such a strain to have an industrially appropriate growth rate and metabolic activity. The cloning ve... | 04/15/2008 |
| 7338801 | Double transposition methods for manipulating nucleic acids Methods are provided for manipulating nucleic acid to produce gene fusions, to delete or clone a portion of a chromosome, or to insert a sequence into a chromosome. The methods employ sequential transposition processes using two or more pairs of inverted repeat tran... | 03/04/2008 |
| 7332341 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells The present invention relates to mutants cells comprising a marker-free modification of a gene, and methods for obtaining and using such mutant cells. ... | 02/19/2008 |
| 7320794 | Transporter protein A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to... | 01/22/2008 |
| 7285399 | Compositions and methods using the yeast YMR107W promoter The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a fermentable carbon source, such as glucose, or a non-fermentable carbon sour... | 10/23/2007 |
| 7271005 | Modulation of bacterial membrane permeability Nucleic acids and polypeptides involved in regulation of membrane permeability in bacteria are disclosed. Also disclosed are methods of increasing sensitivity to antibiotics in multi-drug resistant bacteria by increasing expression of PprA or PprB proteins in bacter... | 09/18/2007 |
| 7247467 | Broad host range pBBR1-based plasmid mutant derivatives having altered plasmid copy number The present invention describes a mutant plasmid replication control region having the ability to convey a phenotype of altered plasmid copy number to the plasmid on which it resides. The mutant replication control region is based on a similar region isolated from t... | 07/24/2007 |
| 7238347 | Suicidal mutant vaccine The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmani... | 07/03/2007 |
| 7220565 | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as ... | 05/22/2007 |
| 7202083 | Plant promoters and plant terminators Promoters capable of efficiently expressing a gene of interest in plants include (1) either a DNA containing SEQ ID No:1 or SEQ ID No:7, or a biological functional equivalent DNA containing SEQ ID No:1 or SEQ ID No:7 that have modifications in their respective nucle... | 04/10/2007 |
| 7195918 | shuttle vector and methods of use An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid com... | 03/27/2007 |
| 7169585 | Papillomavirus vaccine A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recombinant DNA... | 01/30/2007 |
| 7163812 | shuttle vector and methods of use An Actinobacillus succinogenes plasmid vector which provides a means to overexpress proteins in A. succinogenes. The plasmid can be transformed efficiently by electroporation, and replicates in a stable manner in A. succinogenes. The plasmid com... | 01/16/2007 |
| 7148053 | Heterologous G protein coupled receptors expressed in yeast, their fusion with G proteins and use thereof in bioassay Expression vectors and yeast cells that contain a heterologous G protein-coupled receptor gene and a gene mutation that causes increased sensitivity to receptor activation or a gene mutation that permits transcriptional activation of pheromone-responsive genes witho... | 12/12/2006 |
| 7144734 | Enhanced homologous recombination mediated by lambda recombination proteins Disclosed herein are methods for generating recombinant DNA molecules in cells using homologous recombination mediated by recombinases and similar proteins. The methods promote high efficiency homologous recombination in bacterial cells, and in eukaryotic cells such... | 12/05/2006 |
| 7144724 | Process for the production of L-amino acids by fermentation using coryneform bacteria A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino ac... | 12/05/2006 |
| 7125662 | Method of identifying putative antibiotic resistance genes The present invention relates to methods of identifying putative antibiotic resistance genes. According to one embodiment, this is carried out by first isolating a microbial DNA molecule or cDNA which encodes a putative antibiotic resistance protein or polypeptide a... | 10/24/2006 |
| 7125720 | Plasmid maintenance system for antigen delivery The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression pla... | 10/24/2006 |
| 7112435 | Uncoupling of DNA insert propagation and expression of protein for phage display The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage co... | 09/26/2006 |
| 7101713 | DNA transformation efficiency by inhibiting host cell restriction It can be difficult to achieve efficient transformation of many strains of bacterial cells due in part to the presence of one or more restriction and modification (R-M) systems in the cells that restricts unmodified transforming DNA. Phage T7 OCR protein is a potent... | 09/05/2006 |
| 7094573 | Modified shine-dalgarno sequences and methods of use thereof Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments th... | 08/22/2006 |
| 7090994 | Methods of screening for introduction of DNA into a target cell The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant targe... | 08/15/2006 |
| 7070791 | Detection of antibodies against pgp3 antigen in patient sera by enzyme-linked immunoassay A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis, serotype D, was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy on clinical samples in an ELISA format. ... | 07/04/2006 |
| 7070989 | strain secreting human granulocyte colony stimulating factor (G-CSF) The present invention provides a recombinant plasmid vector comprising a kanamycin resistance gene, a promoter, an endoxylanase signal sequence, a nucleotide sequence coding for an oligopeptide consisting of 13 amino acids including 6 consecutive histidine residues,... | 07/04/2006 |
| 7067282 | Compositions and methods using the yeast YLR110C promoter The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a fermentable carbon source, such as glucose, or a non-fermentable carbon sour... | 06/27/2006 |
| 7015033 | Co-expression of recombination proteins Expression vectors are described which permit the recombinant expression of proteins which essentially contain, in addition to nucleic acid encoding the recombinant protein, nucleic acid encoding a non-proteolytic analog of Haemophilus Hin47 protein, with or ... | 03/21/2006 |
| 7009045 | Transformation systems for flavinogenic yeast This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata, and mutants thereof, by electroporation (electrotransformation) and by spheroplast transformation. The invention is also directed to ... | 03/07/2006 |
| 6991900 | Methods for identifying an essential gene in a prokaryotic microorganism Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombinati... | 01/31/2006 |
| 6987026 | Vector for the transformation of and process of transformation thereby The present invention is directed to a recombinant vector for transforming yeast and a process for transforming yeast thereby, more particularly to a recombinant vector comprising a gene encoding a mutated L41 protein having cycloheximide-resistant activity and a ri... | 01/17/2006 |
| 6977176 | Plasmid maintenance system for antigen delivery The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression pla... | 12/20/2005 |
| 6962990 | Fusobacterium nucleic acids, plasmids and vectors The invention provides origin of replication sequences and replication genes and proteins for a plasmid functional in Fusobacterium (e.g., F. nucleatum) and related species. Provided by the invention are also plasmids and vectors that can replicate in ... | 11/08/2005 |
| 6955902 | High throughput DNA sequencing vector High throughput DNA sequencing vectors for generating nested deletions using enzymatic techniques and/or transposition-based techniques are disclosed. Methods of constructing contigs of long DNA sequences and methods of generating nested deletions are also disclosed... | 10/18/2005 |
| 6890528 | Cells for the production of helper dependent adenoviral vectors The present invention relates to cells for the production of helper dependent adenoviral vectors, including at least the following genic units: a first genic unit comprising an adenovirus defective genome having the inverted terminal repeats in head-to-tail configur... | 05/10/2005 |
| 6887702 | Plasmid originated from bifidobacterium, recombinant expression vector using the plasmid and transformation method The present invention relates to a new plasmid originated from (Bifidobacterium) a recombinant expression vector and transformation method using the same. More particularly, the present invention relates to a plasmid pMG1 having nucleotide sequence represente... | 05/03/2005 |
