Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 7387257 | Card recording apparatus and a card storage cassette Regarding a card storage cassette for use in a card recording apparatus in which a plurality of cards are stacked vertically with their face maintained substantially horizontal, the present invention provides in one embodiment a card recording apparatus and its card... | 06/17/2008 |
| 7338800 | In vivo gene transfer The present invention is directed to an in vivo method of transferring DNA from a donor cell to a recipient cell. In a specific embodiment, the method comprises a highly efficient process of bacterial mating. In a preferred embodiment, selection for a recombinant pl... | 03/04/2008 |
| 7326572 | Endoderm cells from human embryonic stem cells This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High qual... | 02/05/2008 |
| 7195916 | Method for expression of small antiviral RNA molecules within a cell In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using t... | 03/27/2007 |
| 7112435 | Uncoupling of DNA insert propagation and expression of protein for phage display The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage co... | 09/26/2006 |
| 6991900 | Methods for identifying an essential gene in a prokaryotic microorganism Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombinati... | 01/31/2006 |
| 6951754 | DNA transfection system for the generation of infectious influenza virus The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably ... | 10/04/2005 |
| 6949349 | Insulin-like growth factor agonist molecules Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal. ... | 09/27/2005 |
| 6867022 | Replication deficient adenovirus vectors and methods of making and using them The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific strategy for making adenoviral vector preparations substantially free ... | 03/15/2005 |
| 6846665 | Method of producing a recombinant adeno-associated virus, suitable means for producing the same and use thereof for producing a medicament The present invention relates to a method for producing a recombinant adeno-associated virus (rAAV), in which at different times a helper construct and also a vector construct are introduced into a suitable cell, and preferably the helper construct does not comprise... | 01/25/2005 |
| 6830885 | Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature This invention relates to the screening of nucleic acids. More particularly, the present invention provides a dysfunctional viral genome capable of both expressing libraries of exogenous nucleic acids and selecting the sequences having a predefined characteristic or... | 12/14/2004 |
| 6830920 | Rapid generation of recombinant adenoviral vectors The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombina... | 12/14/2004 |
| 6780618 | Method for improving genetic stability of foreign insert nucleotide sequence in recombinant poliovirus The present invention relates to (a) methods for improving a genetic stability of an insert nucleotide sequence in a recombinant single-stranded RNA virus vector, which comprises performing a mutagenesis of the foreign insert nucleotide sequence to provide even dist... | 08/24/2004 |
| 6777220 | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof The present invention provides a method of increasing expression of a promoter distal gene in a virus of the order Mononegavirales, and a recombinant virus constructed by such method. Also provided is a method of attenuating a virus of the order Mononegavirales, and... | 08/17/2004 |
| 6696295 | Transducing phages The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient... | 02/24/2004 |
| 6689559 | Efficient hepatitis C virus replicon and its use in identifying antiviral compounds The present invention provides a Hepatitis C Virus (HCV) replicon that efficiently replicates in an eukaryotic cell. The HCV replicon includes a nucleic acid sequence encoding a subgenomic fragments of HCV of any genotype that confer on the RNA the abilit... | 02/10/2004 |
| 6620597 | Method for in vitro amplification of circular DNA A method for generating and amplifying closed circular DNA having a specific sequence in vitro in a cell-free system is disclosed. Prior to the invention of this method, closed circular DNA could only be amplified in vivo in appropriate host cells. The es... | 09/16/2003 |
| 6589732 | Transducing phages The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient... | 07/08/2003 |
| 6558921 | Promoters of the genes glutamate deshydrogenase, ଲ-N-acetylhexosaminidase and γ-actin and their use in filamentous fungi expression, secretion and antisense systems An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is capable of directing expression of DNA downstream of the fra... | 05/06/2003 |
| 6544507 | Anti-neoplastic viral agents A viral DNA construct, and virus encoded thereby, is provided having one or more tumor specific transcription factor binding sites in place of one or more wild type transcription factor binding sites operatively positioned in the promoter region which con... | 04/08/2003 |
| 6500611 | Inviable virus particles as scaffolds for constructing flexible detection systems An innovative detection system for detecting small numbers of target analytes is disclosed. This system provides a novel method for attaching multiple copies of reporter groups to a single site on an analyte of interest. This system preferably comprises a... | 12/31/2002 |
| 6420345 | Methods and reagents for inhibiting angiogenesis Disclosed are methods for inhibiting angiogenesis using cyclin dependent kinase inhibitors (CDKi) and fusion proteins thereof, recombinant viruses comprising transgenes and nucleic acid sequences encoding the same, and liposomes carrying the same as angio... | 07/16/2002 |
| 6406911 | Compositions and methods for sensitive detection of HIV infection and monitoring of drug resistance A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or more additional cell surface receptors necessary to allow ... | 06/18/2002 |
| 6342655 | Plants resistant to WT strains of cucumber mosaic virus CP genes of CMV strains V27, V33, V34, and A35 (CMV-V27, CMV-V33, CMV-V34, and CMV-A35 respectively) are provided.... | 01/29/2002 |
| 6338846 | Recombinant baculovirus, construction method thereof and insect pesticidal composition containing the same A recombinant baculovirus, which produces a recombinant polyhedra made up of a baculovirus polyhedrin (PH), a Bacillus thuringiensis crystal protein (CP) and jellyfish Aequorea victoria green fluorescent protein (GFP), is constructed by introducing a tran... | 01/15/2002 |
| 6335185 | Bacteriophage vectors generated by bacteriophage/plasmid recombination The present invention relates to methods for the generation of lambda (λ) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins, methods for the identification of a λ or P1 bacteriophage ... | 01/01/2002 |
| 6319716 | Bovine adenovirus type 3 genome and vector systems derived therefrom The present invention provides the complete nucleotide sequence of a bovine adenovirus. The invention further provides bovine adenovirus vectors and expression systems which can be used, among other things, for insertion of foreign sequences, for provisio... | 11/20/2001 |
| 6300118 | Plasmids comprising a genetically altered feline immunodeficiency virus genome The present invention pertains to the prevention or lessening of disease in cats caused by Feline Immunodeficiency Virus (FIV). Prevention or lessening of disease is understood to mean the amelioration of any symptoms, including immune system disruptions,... | 10/09/2001 |
| 6265563 | Opioid receptor genes Genes encoding opioid receptors can be retrieved from vertebrate libraries using the murine probe disclosed herein under low-stringency conditions. The DNA sequence shown in FIG. 5 or its complement can be used to obtain the human delta, kappa and mu gene... | 07/24/2001 |
| 6248578 | Infectious clone for human parainfluenza virus type 3 A system for generating recombinant, human parainfluenza virus, particularly infectious, recombinant, human parainfluenza virus type 3 (HPIV-3) is provided. In one embodiment, the system comprises a clone comprising a nucleotide sequence that encodes a fu... | 06/19/2001 |
| 6245504 | Transducing phages of Actinomycetales The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient... | 06/12/2001 |
| 6228620 | Protein complexes having factor VIII:C activity and production thereof Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C... | 05/08/2001 |
| 6218372 | Methods for treating restenosis with p21 The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cell... | 04/17/2001 |
| 6165712 | Methods of transcriptionally modulating expression of viral genes and genes useful for production of proteins The present invention provides a method of transcriptionally modulating the expression of a gene encoding a protein of interest, the expression of which gene is associated with the production in cell culture of a protein encoded by the gene, which compris... | 12/26/2000 |
| 6127601 | Plants resistant to C strains of cucumber mosaic virus Coat protein genes of cucumber mosaic virus strains V27, V33, V34 and A35 (CMV V27, CMV V33, CMV V34, and CMV A35 respectively) are provided.... | 10/03/2000 |
| 6063608 | Cloned genes encoding reverse transcriptase lacking RNase H activity The invention relates to a gene which encodes reverse transcriptase having DNA polymerase activity and substantially no RNase H activity. The invention also relates to vectors containing the gene and hosts transformed with the vectors of the invention. Th... | 05/16/2000 |
| 6057300 | Methods for treating cancers and restenosis with p21 The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cell... | 05/02/2000 |
| 6037150 | Insect sequences for improving the efficiency of secretion of non-secreted proteins in eukaryotic cells An expression cassette useful for the secretion of a heterologous protein from eukaryotic cells comprising a DNA sequence encoding a promoter functionally linked to a DNA sequence coding for the juvenile hormone esterase gene which is linked in frame to a... | 03/14/2000 |
| 6033886 | Recombinant infectious non-segmented negative strand RNA virus The present invention provides the generation of infectious replicating non-segmented negative-stranded RNA virus, entirely from cloned cDNA. This process offers the possibility to introduce mutations into the virus genome by means of recombinant DNA tech... | 03/07/2000 |
| 6022705 | Insect sodium channels gene from insecticide-susceptible and insecticide-resistant house flies The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as we... | 02/08/2000 |
