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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 7932088 | High efficiency transformation of by the lepidopteran transposon, The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as Plasmodium falciparum. The transformation efficiencies are improved up to 100 times over those conventionally known. The... | 04/26/2011 |
| 7745218 | Genome minimization by tn5-coupled cre/loxP excision system Disclosed is a method for developing novel strains deleted specific chromosome sites, using transposon and Cre/loxP site-specific recombination by Cre expression vector, wherein the transposon comprises a selectable marker and loxP site. The method comprises the ste... | 06/29/2010 |
| 7732209 | Hyperactive, non-phosphorylated, mutant transposases of mariner mobile genetic elements The invention relates to hyperactive, non-phosphorylated, mutant transposases of mariner mobile genetic elements. The invention also relates to recombinant nucleotide sequences encoding such transposases. The invention further relates to a method of producing said t... | 06/08/2010 |
| 7550296 | Generation of replication competent viruses for therapeutic use The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease. ... | 06/23/2009 |
| 7393639 | Methods for identifying genes and promoters of interest using the transposon The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterised Fusarium oxysporum Impala transposon in the genome of said fungi. The invention also concerns the re... | 07/01/2008 |
| 7338801 | Double transposition methods for manipulating nucleic acids Methods are provided for manipulating nucleic acid to produce gene fusions, to delete or clone a portion of a chromosome, or to insert a sequence into a chromosome. The methods employ sequential transposition processes using two or more pairs of inverted repeat tran... | 03/04/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7262056 | Enhancing intermolecular integration of nucleic acids using integrator complexes We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents. ... | 08/28/2007 |
| 7256021 | Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammoni... | 08/14/2007 |
| 7232564 | Methods of polyvalent bacteriophage preparation for the treatment of bacterial infections The multivalent strains of bacteriophages, methods of obtaining these and their use in the treatment of bacterial infections, particularly those of drug-resistant bacterial strains, especially arising in mucoviscidosis patients, are provided. ... | 06/19/2007 |
| 7205462 | Inbred corn line G2202 Broadly this invention provides an invention which is inbred corn line G2202. The methods for producing a corn plant by crossing the inbred line G2202 are also encompassed by the invention. Additionally, the invention relates to the various parts of inbred G2202 inc... | 04/17/2007 |
| 7169393 | Antigenic peptide fragments of VapA protein, and uses thereof An isolated peptide fragment of the VapA protein that binds antibodies specific for Rhodococcus equi and the VapA protein. In a preferred form the peptide contains an amino acid sequence of 5 or more amino acid residues that is identical to or homologous to t... | 01/30/2007 |
| 7138279 | Transposon-based transformation system A transposon-based mutagenesis method for altering DNA in Sorangium and other Myxococcales host cells is provided, along with vectors and transposases for use in the method. ... | 11/21/2006 |
| 7125662 | Method of identifying putative antibiotic resistance genes The present invention relates to methods of identifying putative antibiotic resistance genes. According to one embodiment, this is carried out by first isolating a microbial DNA molecule or cDNA which encodes a putative antibiotic resistance protein or polypeptide a... | 10/24/2006 |
| 7101541 | Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution A retroviral vector for gene reconstitution is provided that includes a 3′ portion of a heterologous nucleic acid sequence 5′ of a first att site and a 5′ portion of the heterologous nucleic acid sequence 3′ of a second att site. A sub-portion of the 3′ po... | 09/05/2006 |
| 7101713 | DNA transformation efficiency by inhibiting host cell restriction It can be difficult to achieve efficient transformation of many strains of bacterial cells due in part to the presence of one or more restriction and modification (R-M) systems in the cells that restricts unmodified transforming DNA. Phage T7 OCR protein is a potent... | 09/05/2006 |
| 7090994 | Methods of screening for introduction of DNA into a target cell The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant targe... | 08/15/2006 |
| 7056728 | Compositions and methods for use thereof in modifying the genomes of microorganisms The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other organisms of interest. The invention further includes cells transformed with ... | 06/06/2006 |
| 7001893 | Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for synthesizing inclusion complexes of the anti-tubercular drug, Rifampicin, with ... | 02/21/2006 |
| 6991900 | Methods for identifying an essential gene in a prokaryotic microorganism Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombinati... | 01/31/2006 |
| 6962810 | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac More efficient transfer of genes into host cells or embryos to transform the cells or embryos is facilitated by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed cells or emb... | 11/08/2005 |
| 6943012 | Helper dependent adenoviral vector system and methods for using the same A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human stuffer DNA that provides for in vivo long term, high level expression o... | 09/13/2005 |
| 6913911 | Transgenic microbial polyhydroxyalkanoate producers Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use o... | 07/05/2005 |
| 6852510 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and, more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vectors, ... | 02/08/2005 |
| 6849429 | Viral pseudo-capsids including assembly agonists and antagonists Recombinant hepatitis C virus (HCV) capsid proteins that self-assemble into large spherical virus-like particles structures and viral capsids that include conformational antigenic epitopes are provided. The large spherical virus-like particles structures and viral c... | 02/01/2005 |
| 6841375 | Flavobacterium heparinum expression system This invention is directed to Flavobacterium heparinum for use as a host cell organism for the expression of homologous and heterologous genes. ... | 01/11/2005 |
| 6787360 | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain specified char... | 09/07/2004 |
| 6664082 | Genetically engineered L-sorbose reductase-deficient mutants The present invention provides a genetically engineered microorganism belonging to the genus Gluconobacter or Acetobacter, which has an engineered gene for the biological activity of reducing L-sorbose which is more than 90% non-functional in developing t... | 12/16/2003 |
| 6617163 | Polynucleotides for mutagenesis in fungus comprising a functional gene in magnaporthe and an impala transposon The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterized Fusarium oxysporum Impala transposon in the genome of said fungi. The invention also concerns th... | 09/09/2003 |
| 6599705 | Regulation of fungal gene expression Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.... | 07/29/2003 |
| 6582951 | Method for non-homologous transformation of Yarrowia lipolytica The invention concerns the integration of a gene of interest into the genome of a Yarrowia strain devoid of zeta sequences, by transforming said strain using a vector bearing zeta sequences.... | 06/24/2003 |
| 6528257 | Method for the simultaneous monitoring of individual mutants in mixed populations The present invention relates to an improved and efficient method for simultaneous monitoring of abundance of individual mutants of a microbe in mixed populations where insertion of a known transposon in the genome of a microbe such that each mutant carie... | 03/04/2003 |
| 6518481 | Universal markers of transgenesis The invention relates to methods, cells and nucleic acids for making transgenic animals. The methods generally comprise introducing into a genome of an animal a genetic construct comprising a transcriptional regulatory element operably linked to a heterol... | 02/11/2003 |
| 6504081 | Methods and uses for transposon-based gene targeting The present invention provides methods which greatly facilitate the rapidity in which cells and transgenic animals with targeted genes may be generated. The invention hastens the investigation of cells and transgenic animals bearing lowered expression of ... | 01/07/2003 |
| 6492510 | Insertion sequence element derived from Ralstonia solanacearum The present invention provides three insertion elements and transposases encoded by the insertion elements that are derived from the genome of Ralstonia solanacearum, which has been isolated with a transposon trap vector.... | 12/10/2002 |
| 6485912 | Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof A method of efficiently sequencing multiple exons from complex genomic DNAs is disclosed. The methodology includes the use of bacterial and bacteriophage-derived artificial chromosomes (BBPACS) in novel gene trapping protocols. Targeted gene trapping by h... | 11/26/2002 |
| 6482632 | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain spe... | 11/19/2002 |
| 6448034 | Production of variant nisin The invention provides a method for making a cell which does not contain a natural nisA gene but expresses a variant nisA gene, said method comprising the steps of providing a cell that contains a natural, chromosomal nisA gene and substituting the natura... | 09/10/2002 |
| 6303381 | Insertion sequence A novel insertion sequence, which has been found in the sMMO gene coding for methane monooxygenase of methane-assimilating bacterium Methylococcus capsulatus NCIMB 11132 strain, and has inverted repeat sequences consisting of a sequence of the nucleotide ... | 10/16/2001 |
| 6258571 | High throughput DNA sequencing vector High throughput DNA sequencing vectors for generating nested deletions using enzymatic techniques and/or transposition-based techniques are disclosed. Methods of constructing contigs of long DNA sequences and methods of generating nested deletions are als... | 07/10/2001 |
