Class 435/471 - Introduction of a polynucleotide molecule into or rearrangement of nucleic acid within a microorganism (e.g., bacteria, protozoa, bacteriophage, etc.)

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Processes of inserting polynucleotide molecules into or
No. of patents: 1341
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173429	Characterization of the I-endonuclease from fission yeast Isolated DNAs encoding the enzyme I-SpomI and its recognition and cutting site are provided. The DNA sequences can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-direc...	05/08/2012
8088623	Dominant selection marker for the transformation of fungi The invention relates to a new expression vector for the transformation of eukaryotic cells, in particular fungal cells, or eukaryotic cell organelles as well as to a method for the transformation of eukaryotes, in particular fungi, or eukaryotic cell organelles emp...	01/03/2012
8043857	Recombinant BCG strains with enhanced ability to escape the endosome Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutr...	10/25/2011
8008078	gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. averm...	08/30/2011
8003390	Responses to singlet oxygen The physiological response of a phototroph to singlet oxygen is altered by modulating the interaction between an anti-sigma factor, ChrR, and a sigma factor, σE, or by altering expression of a gene product required for viability in the presence of single...	08/23/2011
7989206	High expression promoters Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeri...	08/02/2011
7968342	Mutant phytase enzymes and natural variants thereof, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement. ...	06/28/2011
7935533	Chromosome manipulation method A universal method for chromosome modification (deletion of a desired DNA region) which does not require any special enzymes or sequences is provided. Further, a method for determining whether the DNA region to be deleted contains a gene essential for growth of the ...	05/03/2011
7919322	Targeted deletions using retroelement-mediated placement of recombination sites The present invention provides methods, nucleic acid constructs, and kits for selectively deleting a region of a nucleic acid sequence. Specifically, it utilizes retargeting retroelements to place site-specific recombination sites at targeted locations in the nuclei...	04/05/2011
7897396	with improved ethanol production in medium containing concentrated sugars and acetate Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were f...	03/01/2011
7892838	Method for the in vivo modification of the synthesis activity of a metabolite by means of the modification of a gene the activity of which is not the original activity The invention relates to a method for altering a protein X such as to modify the characteristics thereof by a) obtaining the mutants X* of the sequence coding for protein X, by means of aleatory mutagenesis, b) transformation of cells with a phenotype [P-] with vect...	02/22/2011
7888123	Method for introducing a gene into An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design a...	02/15/2011
7883895	Methods for enhanced bacterial exopolysaccharide production The present invention provides nucleic acid sequences and variants thereof capable of modulating exopolysaccharide production in Sphingomonas, and provides methods of using such nucleic acid sequences to generate bacteria that hyper-produce exopolysaccharide ...	02/08/2011
7883894	Process for the reversible functional inactivation of the mismatch repair system The present invention relates to a process for allowing homologous recombination between non-identical DNA sequences of an organism and various applications thereof. ...	02/08/2011
7803623	with improved ethanol production in medium containing concentrated sugars and acetate Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas further engineered to reduce activity of the himA gene were found to ...	09/28/2010
7736899	Cells and method for producing proteins comprising an unconventional amino acid The present invention relates to a method for providing bacterial or yeast cells with the capacity to produce a protein, the amino acid sequence of which comprises at least one unconventional amino acid. The method involves (a) introducing at least one missense muta...	06/15/2010
7736898	Thiaminases and thiaminase genes for use in apoptotic therapies This disclosure describes methods for preparing and utilizing thiaminase and thiaminase genes to induce apoptosis in a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Emphasis is on methods for inducing apoptosis in cancer c...	06/15/2010
7732208	Method of conducting homologous recombination The present invention provides a novel method of significantly promoting the ratio of homologous recombination in desirable cells. In order to enhance the ratio of homologous recombination in desirable cells such as eukaryotic cells, mutation is introduced into gene...	06/08/2010
7700358	Coffee mannanase A DNA fragment derived from coffee encoding at least one enzyme involved in the hydrolysis of polysaccharides comprising pure or branched mannan molecules linked to each other via a β (1→4) linkage, and which has the the nucleic acid sequence SEQ ID NO.:1 or whic...	04/20/2010
7695969	Methods for generating hypermutable microbes Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desir...	04/13/2010
7625756	Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrate...	12/01/2009
7622302	Process for improving the manufacture of clavams e.g. clavulanic acid New processes for improving the manufacture of clavams e.g. clavulanic acid. Novel DNA sequences and new microorganisms capable of producing increased amounts of clavulanic acid are also disclosed. ...	11/24/2009
7588940	Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials. The apparatus and method involves use of one or more diffractive optical elements which each receive a lase...	09/15/2009
7550295	Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase This invention provides a modified vaccinia topoisomerase enzyme containing an affinity tag which is capable of facilitating purification of protein-DNA complexes away from unbound DNA. This invention further provides a modified sequence specific topoisomerase enzym...	06/23/2009
7504259	Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast The present invention relates to fungal Δ12 fatty acid desaturases that are able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs co...	03/17/2009
7479389	ARG1, ARG2, ARG3, HIS1, HIS2, HIS5, HIS6 genes and methods for stable genetic integration Novel genes encoding P. pastoris ARG1, ARG2, ARG3, HIS1, HIS2, HIS5 and HIS6 are disclosed. A method for inactivating alternately at least two biosynthetic pathways in a methylotrophic yeast is provided. A method for producing and selecting yeast strains char...	01/20/2009
7439067	Isolated polynucleotides and methods of promoting a morphology in a fungus The invention includes isolated polynucleotide molecules that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention includes a method of enhancing a bioprocess utiliz...	10/21/2008
7435808	Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2 The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, frag...	10/14/2008
7435168	Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ...	10/14/2008
7432100	Variant aldolase and processes for producing an optically active IHOG and an optically active monatin using the same The present invention relates to variant aldolase enzymes that are modified so as to produce IHOG (4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid: IHOG), a process for producing an optically active IHOG using the same, and a process for producing an optically act...	10/07/2008
7427494	Nucleic acid encoding cytokine receptor zcytor17 Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or devel...	09/23/2008
7427503	Method for transferring material in a cell system Described is a method for method for transferring material through the membrane of at least one cell, wherein the transfer is carried out in the presence of trehalose. This method is applicable in particular in the field of genetic engineering and biotechnology....	09/23/2008
7425450	Regulatable growth of filamentous fungi The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemica...	09/16/2008
7425613	PRO1375 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ...	09/16/2008
7425645	Ester-linked gemini surfactant compounds for use in gene therapy This invention relates to newly identified ester-linked Gemini surfactant compounds of formula (I), where Y is either H or (Aa)x where (Aa) is a basic amino acid and x is 1 to 6, to the use of such compounds and to their production. The invention also relates to the...	09/16/2008
7423123	Interleukin-9 antagonist muteins and their pharmacological methods of use This invention relates to IL-9 muteins that inhibit the activity of wild-type IL-9, multimers and Fc-fusion constructs of IL-9 proteins, and an efficient method to purify IL-9 proteins produced by eukaryotic cells. Related formulations, dosages and methods of admini...	09/09/2008
7419791	Methods of screening compounds using a T1R3 hetero-oligomeric taste receptor Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled recept...	09/02/2008
7416859	cloning and expression vectors A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors and particularly in shuttle vectors for the expression of heterol...	08/26/2008
7416881	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th...	08/26/2008
7410801	Lambda phage display system and the process The present invention relates to a process of obtaining recombinant lambdoid bacteriophage with high density display of functional peptides and proteins on surface of said phage comprising of: constructing a donor plasmid having a nucleotide sequence that defines th...	08/12/2008

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Class 435/471 - Introduction of a polynucleotide molecule into or rearrangement of nucleic acid within a microorganism (e.g., bacteria, protozoa, bacteriophage, etc.)