Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8034620 | Lentiviral packaging cells and uses therefor Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 10/11/2011 |
| 7732207 | Method for expression of small antiviral RNA molecules within a cell In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be ... | 06/08/2010 |
| 7439037 | Use of aminoglycoside resistance gene Use of aminoglycoside resistance gene product for achieving high-density growth of animal cells. ... | 10/21/2008 |
| 7361354 | Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Co... | 04/22/2008 |
| 7361641 | Methods and compositions for genomic modification The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting constru... | 04/22/2008 |
| 7335505 | Materials and methods relating to protein aggregation in neurodegenerative disease The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor protein is associated with a disease state in which the precursor protein ... | 02/26/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7311907 | Lentiviral packaging cells Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 12/25/2007 |
| 7250293 | Complementing cell lines A packaging cell line capable of complementing recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary diploid human cells transformed by adenovirus E1 sequences either operatively ... | 07/31/2007 |
| 7241600 | Process for the preparation of L-amino acids using strains of the enterobacteriaceae family The invention relates to a process for the preparation of L-amino acids, in particular L-threonine. ... | 07/10/2007 |
| 7226587 | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be utilized for fracture repair. The invention further discloses composition... | 06/05/2007 |
| 7202079 | Bovine immunodeficiency virus (BIV) based vectors This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a ... | 04/10/2007 |
| 7195916 | Method for expression of small antiviral RNA molecules within a cell In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using t... | 03/27/2007 |
| 7125712 | Bovine immunodeficiency virus (BIV) based vectors This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a ... | 10/24/2006 |
| 6977297 | Methods and means for modification of glucosinolates in plants GSL-ELONGASE gene of Arabidopsis thaliana and other plants, especially Brassica oleracea, Brassica rapa and Brassica napus. The nature and level of glucosinolates in plants can be modified by transgenic expression of the genes or control of the ... | 12/20/2005 |
| 6958226 | Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using the viral accessory protein independent HIV-derived retroviral vector... | 10/25/2005 |
| 6955919 | Lentiviral packaging cells and uses therefor Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 10/18/2005 |
| 6951754 | DNA transfection system for the generation of infectious influenza virus The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably ... | 10/04/2005 |
| 6946266 | Gene transfer in chicken bursal stem cells The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the immunoglobulin molecules of avian species specifically chickens. The te... | 09/20/2005 |
| 6916611 | Expression vector system and a method for optimization and confirmation of DNA delivery and quantification of targeting frequency An expression vector system comprising a pair of expression vectors constructed from a wild-type and a mutant version of a maker, reporter or selection gene, and a method for optimization and confirmation of DNA delivery and of gene targeting and for quantification ... | 07/12/2005 |
| 6913922 | Serotype of adenovirus and uses thereof Adenovirus serotypes differ in their natural tropism. The adenovirus serotypes 2, 4, 5, and 7 all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes 40 and 41 have a natural affiliation towards the gastrointestina... | 07/05/2005 |
| 6890716 | Recombinant cell line and screening method for identifying agents which regulate apoptosis and tumor suppression This invention provides recombinant cell lines and screening methods useful for identifying agents that induce apoptosis in target cells and therefore may be used to advantage in the treatment of neoplastic disorders. ... | 05/10/2005 |
| 6855513 | Quorum sensing signaling in bacteria The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginos... | 02/15/2005 |
| 6852510 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and, more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vectors, ... | 02/08/2005 |
| 6846665 | Method of producing a recombinant adeno-associated virus, suitable means for producing the same and use thereof for producing a medicament The present invention relates to a method for producing a recombinant adeno-associated virus (rAAV), in which at different times a helper construct and also a vector construct are introduced into a suitable cell, and preferably the helper construct does not comprise... | 01/25/2005 |
| 6825038 | Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more... | 11/30/2004 |
| 6821955 | Macroaggregated protein conjugates as oral genetic immunization delivery agents This invention relates to the development of an expression vector containing an antigenic genomic sequence, which is bound to an aggregated protein-polycationic polymer conjugate. More particularly it relates to the use of the expression vector as an oral DNA vaccin... | 11/23/2004 |
| 6808905 | Lentiviral vectors encoding clotting factors for gene therapy Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentivirus... | 10/26/2004 |
| 6800435 | Insect sodium channels from insecticide-susceptible and insecticide-resistant house flies The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as... | 10/05/2004 |
| 6783756 | Methods for regulating gene expression A method for regulating expression of a tet operator-linked gene in a cell of a subject is disclosed. In one embodiment, the method involves introducing into the cell a nucleic acid molecule encoding a tetracycline-controllable transactivator (tTA), the tTA comprisi... | 08/31/2004 |
| 6777235 | Complementation trap Methods and DNA constructs are provided for detection and manipulation of a target eukaryotic gene whose expression is restricted to certain tissues or specialized cell types. The methods include transforming a cell with a first indicator component under the control... | 08/17/2004 |
| 6699657 | In vitro system for replication of RNA-dependent RNA polymerase (RDRP) viruses An in vitro method to conduct genomic replication of the viral genomes of viruses that utilize RNA-dependent RNA polymerase for replication (RDRP viruses), such as HCV. The method employs a construct comprising the 3' and 5' untranslated regions (UTRs) of... | 03/02/2004 |
| 6649373 | Use of trans-activation and CIS-activation to modulate the persistence of expression of a transgene Provided are methods of modulating the persistence of the expression in a cell of a transgene, such as a transgene in a non-Herpes vector or in at least E4Ɗ adenoviral vector, and related systems. One method comprises contacting the cell with a non-Herpe... | 11/18/2003 |
| 6635478 | Production of recombinant proteins using herpes virus promoters and VP16 transactivators Stable cell lines are produced to express high levels of a gene product of interest using VP16, a herpes simplex virus transactivator, and a promoter from herpes simplex virus which is a target for VP16. The transactivator and promoter are introduced to a... | 10/21/2003 |
| 6632672 | Methods and compositions for genomic modification The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a target... | 10/14/2003 |
| 6620618 | Complementary cell line for the growth of adenovirus mutants with a deleted protease gene An adenovirus vector/packaging cell line system is disclosed, in which the vector replication is blocked by deletion of a single gene, which deletion does not interfere with any other viral functions. The deleted gene is the gene of the adenovirus proteas... | 09/16/2003 |
| 6586206 | Methods for making recombinant proteins using apoptosis inhibitors The invention provided improved methods of making and producing recombinant proteins in in vitro cultures of host cells using apoptosis inhibitors. The use of one or more apoptosis inhibitors in the methods can reduce apoptosis in the cell cultures and ma... | 07/01/2003 |
| 6551825 | PiggyBac transposon-based genetic transformation system for insects The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host c... | 04/22/2003 |
| 6541258 | AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors The present invention provides AAV "split-packaging" genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a vari... | 04/01/2003 |
| 6528276 | Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity The present invention relates to novel fusion proteins, DNA molecules encoding the same, vectors comprising the DNA molecules, and host cells containing the vectors for use in measuring protease activity using a novel transcriptional assay. This invention... | 03/04/2003 |
