Bizarre Patents
Crispy Chip Sandwich and Process of Producing a Sandwich Product
A food product comprising a multilayer cookie or snack having outer layers formed from a crispy type edible food product such as a potato chip or corn chip, etc. with an intermediate marshmallow layer being in contact with the inner surface of each crispy chip and one or more filler substances.
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| Number | Title | Issue Date |
| 7294500 | Mosaic infectious bursal disease virus vaccines The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable of growing in a cell that is not derived from a bursa cell, or an inf... | 11/13/2007 |
| 7262056 | Enhancing intermolecular integration of nucleic acids using integrator complexes We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents. ... | 08/28/2007 |
| 7132404 | Compositions for receptor/liposome mediated transfection and methods of using same The present invention provides a composition of matter for introducing an exogenous nucleic acid molecule into a target cell, comprising a liposome, a ligand polymeric scaffold, wherein the ligand can bind to a cell surface receptor or molecule. The invention also p... | 11/07/2006 |
| 6444441 | Production of human mutated proteins in human cells by means of homologous recombination The invention concerns a process for the production of muteins of eukaryotic polypeptides in eukaryotic cells by means of homologous recombination. The invention additionally concerns a process for the production of human cells which are suitable for the ... | 09/03/2002 |
| 6365394 | Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus Novel cell lines useful for trans-complementing E1-deleted adenoviral vectors are described. The cell lines are capable of providing high yields of E1-deleted adenoviral vectors in the absence of replication-competent adenovirus over multiple passages.... | 04/02/2002 |
| 6218123 | Construction of normalized cDNA libraries from eucaryotic cells A new technology is described that allows for the rapid and efficient construction of complex cDNA libraries from cultured eukaryotic cells. The technology exploits eukaryotic biology by using transgenic constructs that have been nonspecifically inserted ... | 04/17/2001 |
| 6080575 | Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least ... | 06/27/2000 |
| 6069296 | Regulators of G-protein signalling Disclosed is substantially pure DNA encoding a C. elegans Egl-10 polypeptide; substantially pure Egl-10 polypeptide; methods of obtaining RGS encoding DNA and RGS polypeptides; and methods of using the RGS DNA and RGS polypeptides to regulate G-protein si... | 05/30/2000 |
| 5981214 | Production of proteins using homologous recombination Methods and compositions are provided for expression of mammalian genes in culture. An amplifiable gene is introduced by homologous recombination in juxtaposition to a target gene, the resulting combination of amplifiable gene and target gene transferred ... | 11/09/1999 |
| 5976833 | Method for animal cell culture The object of the present invention is to provide a method for improving productivity in the production of useful substances by animal cells. The present invention discloses a method for animal cell culture to produce a desired substance, comprising the s... | 11/02/1999 |
| 5922583 | Methods for production of recombinant plasmids The invention relates to a culture system for stable and high-level production of DNA contained on recombinant plasmids, and to the bacteria and plasmids which comprise the culture system. The bacterial cell chromosome is irreversibly altered, in one embo... | 07/13/1999 |
| 5879919 | Method of using eukaryotic expression vectors comprising the BK virus enhancer The present invention is a method of using the BK enhancer in tandem with a eukaryotic promoter to promote transcription of DNA that encodes a useful substance. The method of the present invention requires the presence of the E1A gene product for maximum ... | 03/09/1999 |
| 5854021 | Enhance protein production method An expression vector comprising a promoter, a coding sequence of a heterologous protein, the coding sequence being operably linked to the promoter, and an intronic sequence downstream of the promoter and upstream of the coding sequence, the intronic seque... | 12/29/1998 |
| 5807742 | Neurokinin receptor cell lines A method for producing high level expression of neuropeptide receptors and stable cell lines useful therein. This method involves culturing a cell line containing amplified copies of a cDNA sequence encoding a neuropeptide receptor containing an expressio... | 09/15/1998 |
| 5776746 | Gene amplification methods The present invention provides improved methods for the amplification and expression of recombinant genes in cells. The methods of the present invention permit the isolation of cell lines which have co-amplified input recombinant sequences which encode an... | 07/07/1998 |
| 5741682 | Expression induction method Disclosed is a method of producing increased amounts of a protein of interest in a cell by induction. The method includes transfecting a cell with multiple copies of an expression vector, each copy of which includes an expressible gene encoding an enzymat... | 04/21/1998 |
| 5691170 | Generation of hybrid genes and proteins by virus-mediated recombination The ability of viruses to undergo recombination within tandemly arranged homologous sequences can be utilized to generate chimeric genes and proteins. Tandemly arranged homologous sequences will rapidly degenerate in a random fashion to yield a single cop... | 11/25/1997 |
| 5631158 | Methods and compositions for high protein production from non-native DNA Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creat... | 05/20/1997 |
| 5578461 | Gene manipulation and expression using genomic elements Expression of mammalian target genes is achieved by employing chromosomal target DNA, either native primary cells or YACs in a yeast host, where the YACs include a fragment of a mammalian chromosome, the fragment comprising the target gene. Employing homo... | 11/26/1996 |
| 5561053 | Method for selecting high-expressing host cells A method for selecting recombinant host cells expressing high levels of a desired protein is described. This method utilizes eukaryotic host cells harboring a DNA construct comprising a selectable gene (preferably an amplifiable gene) and a product gene p... | 10/01/1996 |
| 5550036 | Method for co-amplification of human protein C genes in human cells The present invention is a method of using the BK enhancer in tandem with a eukaryotic promoter to promote transcription of DNA that encodes a useful substance. The method of the present invention requires the presence of the E1A gene product for maximum ... | 08/27/1996 |
| 5348874 | Eukaryotic transposable element Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein (or a portion of a transposase protein). The isolated transposable elements or the isolated DNA sequences being characterized by the ability to hybr... | 09/20/1994 |
| 5324643 | Method of conferring resistance to retroviral infection In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective vir... | 06/28/1994 |
| 5298400 | Polynucleotide constructs for secreted glycosylated plasminogen activator inhibitor-2 (PAI-2) This invention relates to PAI-2 and its expression as a recombinant molecule in eukaryotic cell lines as a glycosylated secreted molecule, to the constructs expressing it, to host cells expressing it, to compositions comprising it, to methods of treatment... | 03/29/1994 |
| 5272071 | Method for the modification of the expression characteristics of an endogenous gene of a given cell line Normally transcriptionally silent genes in a cell line or microorganism may be activated for expression by inserting a DNA regulatory element which is capable of promoting the expression of a normally expressed gene product in that cell or which is promis... | 12/21/1993 |
| 5256545 | Sterol Regulatory Elements Disclosed are discrete functionally translocatable DNA segments, termed Sterol Regulatory Elements (SREs), which are fused to heterologous structural genes to provide sterol regulatory capability to the thus formed hybrid gene. The hybrid genes respond to... | 10/26/1993 |
| 5238820 | Multiply-amplifiable vectors for high level expression of exogenuos DNA A transformation vector containing a heterologous product gene and two or more different heterologous selectable amplifiable marker genes is described. Preferably, the marker genes form a polycistronic transcription unit. Also described is a method for ob... | 08/24/1993 |
| 5219738 | Animal cell transformant, method for obtaining the transformant and method for producing desired foreign gene product by using the transformant By screening an animal cell transformant, which has been obtained by introducing into wild-type animal cells a wild-type DHFR gene and a structural gene which codes a desired useful substance, with a medium containing methotrexate (MTX) at a concentration... | 06/15/1993 |
| 5198349 | Method for producing factor VIII:C and analogs An improved method for producing Factor VIII:c is disclosed. The method involves culturing mammalian cells which contain DNA encoding Factor VIII:c and which are capable of expressing Factor VIII:c. In accordance with this invention the cells are cultured... | 03/30/1993 |
| 5168051 | Nucleic acid encoding TGF-ଲ its uses Nucleic acid encoding TGF-ଲ has been isolated and cloned into vectors which are replicated in bacteria and expressed in eukaryotic cells. TGF-ଲ is recovered from transformed cultures for use in known therapeutic modalities. Nucleic acid encodi... | 12/01/1992 |
| 5155020 | Recombinant poxvirus host range selection system What is described is a selection system for the cloning and expression of open reading frames in poxviruses, particularly vaccinia virus. The selection system is based on a conditional lethal mutant (host range) of poxviruses. A deletion/recombinant mutan... | 10/13/1992 |
| 5149636 | Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products Multiple copies of a foreign DNA I coding for the production of a protein may be introduced into eucaryotic cells by cotransforming suitable cells with foreign DNA I and with foreign DNA II which includes a functionally deficient, amplifiable gene coding ... | 09/22/1992 |
| 5122464 | Method for dominant selection in eucaryotic cells Recombinant DNA sequences which encode the complete amino acid sequence of a glutamine synthetase, vectors containing such sequences, and methods for their use, in particular as dominant selectable markers, for use in co-amplificiation of non-selected gen... | 06/16/1992 |
| 5082774 | Recombinant human nerve growth factor An expression vector replicable in a mammalian cell includes a prepro-NGF encoding DNA sequence operably linked with regulatory DNA capable of effecting the expression of the prepro-NGF encoding DNA sequence in the cell. Also, a mammalian cell is transfec... | 01/21/1992 |
| 5081028 | Preparation of transformed hosts which express binding factor related polypeptides The invention concerns polypeptides related to human immunoglobulin E binding factors (IgE-Bfs), mRNa, DNAs and hybrid vectors coding for said polypeptides, hosts containing said hydrid vectors, processes for the preparation of said polypepties, mRNAs, DN... | 01/14/1992 |
| 5057417 | Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and growth hormone binding protein and methods of obtaining such DNA are provided, together with expre... | 10/15/1991 |
| 5043270 | Intronic overexpression vectors DNA constructs are provided employing intronically positioned expression, systems, where one of the genes is a dominant gene, usually amplifiable, and the other gene encodes a sequence of interest. Higher levels of co-expression are achieved than when the... | 08/27/1991 |
| 5017478 | Transfected cells containing plasmids having genes oriented in opposing directions and methods of using This invention relates generally to recombinant DNA techniques and to the expression of mammalian polypeptides in genetically engineered eukaryotic cells. Specifically, the invention relates to preferred plasmid constructs and methods that increase levels... | 05/21/1991 |
| 5011795 | Human tPA production using vectors coding for DHFR protein A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR ... | 04/30/1991 |
| 5011776 | Shuttle vector, utilizing the E. coli asparagine synthetase gene, and capable of dominant transfection and amplification in animal cells A shuttle vector capable of dominant transfection of both animal and bacterial cells and of amplification in animal cells has been constructed. This vector contains the cloned bacterial gene coding for asparagine synthetase; it is shown that animal cells ... | 04/30/1991 |
