Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8097460 | Ethanol production in The present invention relates to the production of ethanol as a product of bacterial fermentation. In particular this invention relates to a novel method of gene inactivation and gene expression based upon homologous recombination. The method is particularly useful ... | 01/17/2012 |
| 8088622 | P27 and P21 in gene therapies The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21cip1/waf1 and/or p27, cyclin dependent kinase inhibitors. In the absence of p27 activity, progenitor cells move into... | 01/03/2012 |
| 7972856 | Targeted gene modification by parvoviral vectors This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic mod... | 07/05/2011 |
| 7888121 | Methods and compositions for targeted cleavage and recombination Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositio... | 02/15/2011 |
| 7820442 | Activation Induced Deaminase (AID) The present invention identifies that the expression of Activation Induced Deaminase (AID) or its homologues in cells confers a mutator phenotype and thus provides a method for generating diversity in a gene or gene product as well as cell lines capable of generatin... | 10/26/2010 |
| 7638334 | Method for generating engineered cells by homologously recombining segments having increased degeneracy Inhibitors of mismatch repair can be used to generate hypermutable cells and organisms. By inhibiting this process in cells, new cell lines and varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of homolog... | 12/29/2009 |
| 7604995 | Compositions, kits, and methods for stimulation of homologous recombination A method of stimulating homologous recombination by creating at least one nick in a targeted polynucleotide sequence. Wherein nonhomologous recombination is suppressed resulting in increasing the ratio of targeted to nontargeted events. A method of increasing double... | 10/20/2009 |
| 7435591 | Compositions and methods for increasing animal size growth rate The present invention relates to germ line and somatic cells comprising a mutant p27kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growt... | 10/14/2008 |
| 7410799 | In vivo production and delivery of erythropoietin or insulinotropin for gene therapy The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes erythropoietin or an insulinotropin [e.g., derivatives of glucagon-l... | 08/12/2008 |
| 7399901 | Mutated gene coding for a lat protein and the biological applications thereof The present invention relates to a mutated gene coding for a mutant LAT protein leading to exaggerated TH2 differentiation. The invention relates to biological structures containing the mutant, particularly non-human LAT gene, mutated animals, plasmids, c... | 07/15/2008 |
| 7361754 | Genetically purified gellan gum Mutational inactivation of proteins involved in para-cresol production in certain milk products results in improved taste and odor. The undesirable para-cresol forms over time as a result of enzymes produced by the bacterium that produces gellan gum. Since the gella... | 04/22/2008 |
| 7309781 | Cysteine variants of granulocyte colony-stimulating factor The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 12/18/2007 |
| 7309605 | Nucleotide sequence encoding the enzyme I-I and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 12/18/2007 |
| 7303894 | Detection of phenols using engineered bacteria Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate transcriptional activator senses the inducing chemical. Creation of bacte... | 12/04/2007 |
| 7294500 | Mosaic infectious bursal disease virus vaccines The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable of growing in a cell that is not derived from a bursa cell, or an inf... | 11/13/2007 |
| 7288251 | Antibodies to CD40 The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof.... | 10/30/2007 |
| 7285700 | Plastid directed DNA constructs comprising chimeric plastid targeting regions, vectors containing same and methods of use thereof This invention relates to methods and compositions for obtaining Arabidopsis and Brassica plants. Specifically, the method provides culturing protocols and compositions that facilitate the regeneration of transformed plants following delivery of benefi... | 10/23/2007 |
| 7279334 | Methods for inducing targeted stimulation of meiotic recombination and kits for performing said methods The Invention pertains to methods, kits, molecules and cells to increase the rate or recombination and/or target recombination in dividing cells. In a particular aspect, the invention concerns methods and kits to induce targeted meiotic recombination. ... | 10/09/2007 |
| 7279463 | Triple-helix forming oligonucleotides for targeted mutagenesis A high affinity, triplex-forming oligonucleotide and methods for use thereof wherein an oligonucleotide is used to form a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the binding of the ol... | 10/09/2007 |
| 7273758 | Methods for inducing targeted stimulation of meiotic recombination and kits for performing said methods The invention pertains to methods, kits, molecules and cells to increase the rate or recombination and/or target recombination in dividing cells. In a particular aspect, the invention concerns methods and kits to induce targeted meiotic recombination. ... | 09/25/2007 |
| 7270809 | Cysteine variants of alpha interferon-2 The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 09/18/2007 |
| 7271000 | Nucleotide sequence encoding the enzyme I-Scel and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 09/18/2007 |
| 7258995 | Compositions and methods for affecting virulence determinants in bacteria A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A pr... | 08/21/2007 |
| 7253334 | Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells. ... | 08/07/2007 |
| 7250293 | Complementing cell lines A packaging cell line capable of complementing recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary diploid human cells transformed by adenovirus E1 sequences either operatively ... | 07/31/2007 |
| 7250556 | Transposable elements in rice and methods of use Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein or a portion of a transposase protein. The isolated transposable elements or the isolated DNA sequences are members of the mPing/Pong family of transposable el... | 07/31/2007 |
| 7235360 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined... | 06/26/2007 |
| 7232885 | Termini cysteine-added variants of granulocyte colony stimulating factor The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 06/19/2007 |
| 7226785 | Targeted chromosomal genomic alterations with modified single stranded oligonucleotides Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2... | 06/05/2007 |
| 7223390 | Insertion of furin protease cleavage sites in membrane proteins and uses thereof Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual membrane-free domain that retains its native conformation. This protocol can be u... | 05/29/2007 |
| 7220542 | Expression cloning in filamentous fungi Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are useful in processes for producing the proteins of interest. ... | 05/22/2007 |
| 7217699 | Compositions comprising genome segments and methods of using the same Methods of treating an individual who has a disease or disorder associated with one or more genetic mutations or undesirable alleles in genomic DNA of the individual, or preventing an individual from developing a disease or disorder associated with one or more genet... | 05/15/2007 |
| 7214779 | Termini cysteine-added variants of granulocyte-macrophage colony stimulating factor The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 05/08/2007 |
| 7214532 | Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention ... | 05/08/2007 |
| 7214536 | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 05/08/2007 |
| 7214515 | Viral delivery system for infectious transfer of large genomic DNA inserts The present invention relates to HSV-based amplicon vectors carrying a genomic DNA fragment, and methods of constructing and using the same. Included within the present invention is a method of converting any large capacity DNA cloning vector, such as a BAC or PAC, ... | 05/08/2007 |
| 7201899 | Materials and methods for management of hyperacute rejection in human xenotransplantation Human pre-formed xenoantibodies play an important role in the hyperacute rejection response in human xenotransplantation. Disclosed are materials and methods for removing or neutralizing such antibodies. Also disclosed are materials and methods for reducing or elimi... | 04/10/2007 |
| 7196187 | Method for producing antibody fragments An expression library comprising a repertoire of nucleic acid sequences cloned from a non-immunised source, each nucleic acid sequence encoding at least part of a variable domain of a heavy chain derived from an immunoglobulin naturally devoid of light chains (VHH) ... | 03/27/2007 |
| 7186552 | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. ... | 03/06/2007 |
| 7183105 | Eubacterial minicells and their use as vectors for nucleic acid delivery and expression Th invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and agents for drug discovery. ... | 02/27/2007 |
