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| Number | Title | Issue Date |
| 8088621 | Adenoviral fiber exchange shuttle system The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors. ... | 01/03/2012 |
| 8026098 | Process for the removal of selectable marker gene sequences The invention relates to a process for the removal of selectable marker gene sequences, in particular antibiotic gene sequences, from nucleic acid molecules. The invention further relates to the application of this process in the unlabelled integration and deletion ... | 09/27/2011 |
| 7968341 | Sequence specific DNA recombination in eukaryotic cells The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA ... | 06/28/2011 |
| 7947501 | Gene recombination exchange system for stable gene modification in human ES cells A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) s... | 05/24/2011 |
| 7625755 | Conditional knockout method for gene trapping and gene targeting using an inducible gene silencer A method for conditionally knocking out and altering gene function and genetic sequences that can be used in such methods, for use in gene trapping and gene targeting. Specifically, the genetic sequence is a inducible gene silencer comprising: (a) a splice acceptor ... | 12/01/2009 |
| 7521240 | Chromosome-based platforms Artificial chromosomes, including ACes, that have been engineered to contain available sites for site-specific, recombination-directed integration of DNA of interest are provided. These artificial chromosomes permit tractable, efficient, rational engineering of the ... | 04/21/2009 |
| 7517688 | Method for ligating nucleic acids and molecular cloning The invention provides cells and methods of circularizing linear DNA molecules. The cell is an isolated Escherichia coli cell which transiently expresses the Cre recombinase protein from an integrated Cre recombinase gene, and which is at least transiently re... | 04/14/2009 |
| 7491539 | Sequence specific DNA recombination in eukaryotic cells The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA ... | 02/17/2009 |
| 7371577 | FLP-mediated gene modification in mammalian cells, and compositions and cells useful therefor A gene activation/inactivation and site-specific integration system has been developed for mammalian cells. The invention system is based on the recombination of transfected sequences by FLP, a recombinase derived from Saccharomyces. In several cell lines, FL... | 05/13/2008 |
| 7364750 | Autogene nucleic acids encoding a secretable RNA polymerase This invention provides methods, nucleic acids, compounds, and compositions for expressing a product of interest in a cell that involve a secretable RNA Polymerase. ... | 04/29/2008 |
| 7361641 | Methods and compositions for genomic modification The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting constru... | 04/22/2008 |
| 7351877 | Lambda integrase mediated recombination in plants The present disclosure provides methods for obtaining the targeted integration of a DNA molecule into the genome of a host cell using a recombinase. The methods disclosed herein can be used with a variety of host cells, including, for example, dicotyledonous and mon... | 04/01/2008 |
| 7335761 | Avian gene expression controlling regions The present invention includes avian ovomucoid gene expression controlling regions which may be operably linked to one or more useful amino acid coding sequences. ... | 02/26/2008 |
| 7309605 | Nucleotide sequence encoding the enzyme I-I and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 12/18/2007 |
| 7304222 | Inbred corn line PHENE A novel inbred maize line designated PHENE and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHENE with another maize plant. Methods for producing a maize plant containing in its genetic material o... | 12/04/2007 |
| 7297850 | Inbred corn line PHAPT A novel inbred maize line designated PHAPT and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHAPT with another maize plant. Methods for producing a maize plant containing in its genetic material o... | 11/20/2007 |
| 7294507 | Ovomucoid promoters and methods of use The present invention includes nucleic acid molecules comprising an artificial chromosome and an avian ovomucoid gene expression controlling region operably linked to the coding sequence of a useful polypeptide. ... | 11/13/2007 |
| 7285538 | Gene repair involving in vivo excision of targeting DNA Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in an individual in need thereof. ... | 10/23/2007 |
| 7276352 | Induction of β cell differentiation in human cells by stimulation of the GLP-1 receptor The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured... | 10/02/2007 |
| 7273973 | Inbred corn line PHEHG A novel inbred maize line designated PHEHG and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHEHG with another maize plant. Methods for producing a maize plant containing in its genetic material o... | 09/25/2007 |
| 7273757 | Recombinant vector containing MJ1 gene and method of site-specific integration using the same The present invention relates to a recombinant vector comprising MJ1 gene coding an integrase derived from Enterococcus temperate bacteriophage φ FC1 and an integration method using the vector. More particularly, the present invention relates to a recombinan... | 09/25/2007 |
| 7271326 | Inbred corn line PHAR1 A novel inbred maize line designated PHAR1 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHAR1 with another maize plant. Methods for producing a maize plant containing in its genetic material o... | 09/18/2007 |
| 7271327 | Hybrid maize plant and seed 33Y74 A novel hybrid maize variety designated 33Y74 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 33Y74 wi... | 09/18/2007 |
| 7271000 | Nucleotide sequence encoding the enzyme I-Scel and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 09/18/2007 |
| 7267984 | Recombination assembly of large DNA fragments A method of assembling large DNA fragments in a chromosome using site specific recombinases and alternating excisionases. The method may be performed in vitro or in vivo, but larger assemblies are possible when the assembly is performed in vivo. For an in vivo assem... | 09/11/2007 |
| 7244876 | Process of rapid variety-independent plant transformation Disclosed is a method of making transgenic plants. Heterologous DNA is first introduced into a donor plant, plant cell or protoplast, and then moved from the donor to a recipient plant, plant cell or protoplast unaccompanied by any native genomic DNA of the donor. T... | 07/17/2007 |
| 7238854 | Method of controlling site-specific recombination The present invention provides methods for the conditional or regulated expression of a site-specific recombinase using split intein-mediated protein splicing. This enhances the temporal and tissue-specificity of trait gene expression and allows for fine tuning of e... | 07/03/2007 |
| 7226782 | Plant centromere compositions The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.... | 06/05/2007 |
| 7223601 | Method for the integration of foreign DNA into eukaryotic genomes Compositions and methods for introducing a DNA of interest into a genomic target site are provided. In particular, the methods and compositions involve the use of a combination of target sites for two site specific recombinases and expression of a chimeric recombina... | 05/29/2007 |
| 7214536 | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 05/08/2007 |
| 7211718 | Hybrid maize plant and seed 33G58 A novel hybrid maize variety designated 33G58 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 33G58 wi... | 05/01/2007 |
| 7205148 | Genome mutation by intron insertion into an embryonic stem cell genome Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombinat... | 04/17/2007 |
| 7202403 | Hybrid maize plant and seed 32B81 A novel hybrid maize variety designated 32B81 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 32B81 wi... | 04/10/2007 |
| 7199294 | Hybrid maize plant and seed 32H20 A novel hybrid maize variety designated 32H20 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 32H20 wi... | 04/03/2007 |
| 7198924 | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more diff... | 04/03/2007 |
| 7196256 | Hybrid maize plant and seed 37Y12 A novel hybrid maize variety designated 37Y12 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 37Y12 wi... | 03/27/2007 |
| 7196244 | Method of transposon-mediated mutagenesis in the nematode caenorhabditis elegans The present invention provides methods for generating and identifying mutations in Caenorhabditis elegans. Disclosed herein are methods for introducing DNA into the C. elegans germline, methods for expressing DNA in the C. elegans germline, and ... | 03/27/2007 |
| 7196255 | Hybrid maize plant and seed 35F38 A novel hybrid maize variety designated 35F38 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for producing a maize plant that comprises crossing hybrid maize variety 35F38 wi... | 03/27/2007 |
| 7193144 | Inbred corn line PHCJP A novel inbred maize line designated PHCJP and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize line PHCJP with another maize plant. Methods for producing a maize plant containing in its genetic material o... | 03/20/2007 |
| 7169384 | Tumor suppressor CAR-1 The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney and breast cancers, and the CAR-1 ubiquitous expression of the correspo... | 01/30/2007 |
