Quotables
"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7943379 | Production of rAAV in vero cells using particular adenovirus helpers The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, in some embodiments the invention contemplates the use of an adenovirus known as Simian Adenovirus 13 (SAdV-13) and Vero cells for production... | 05/17/2011 |
| 7820441 | Production of viral vectors The present invention relates to methods and compositions for the production of viral vectors. In particular, the present invention provides methods and compositions for faster, higher titer and higher purity production of viral vectors (e.g. adenoviral vectors). In... | 10/26/2010 |
| 7361354 | Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Co... | 04/22/2008 |
| 7271004 | Transgenic expression of a phytochrome a gene An isolated nucleic acid construct including a nucleic acid molecule encoding a light-labile, phytochrome A, a light-inducible promoter which is 5′ to the nucleic acid molecule encoding a light-labile, phytochrome A, and a terminator region which is 3′ to the nu... | 09/18/2007 |
| 7271002 | Production of adeno-associated virus in insect cells A method of producing an adeno-associated virus (AAV) in an insect cell comprising (i) providing at least one insect cell-compatible vector comprising a first nucleotide sequence comprising at least one AAV ITR nucleotide sequence, a second nucleotide sequence conta... | 09/18/2007 |
| 7264818 | BAV packaging regions and E1 transcriptional control regions The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus v... | 09/04/2007 |
| 7252991 | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retr... | 08/07/2007 |
| 7229823 | Methods for increasing the efficiency of recombinant AAV product The present invention relates to methods and compositions for increasing the production of high titre stocks of recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the ob... | 06/12/2007 |
| 7216113 | Remote Execution of Materials Library Designs Methods, apparatus, and business processes enabling individual chemists to design, order, and obtain data for multiple experiments or measurements in a timely and cost-effective manner. In particular implementations, the invention includes methods and apparatus for ... | 05/08/2007 |
| 7195916 | Method for expression of small antiviral RNA molecules within a cell In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using t... | 03/27/2007 |
| 7148341 | AAV DNA comprising helper virus sequences The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both. ... | 12/12/2006 |
| 7132277 | Helper dependent vector system for gene therapy The present invention features helper-dependent adenoviral vector elements, and helper adenoviral elements, that enhance the production and isolation of helper-dependent adenoviral vectors. Such elements include a modified packaging signal having low homology to, an... | 11/07/2006 |
| 7125705 | Polynucleotides for use in recombinant adeno-associated virus virion production Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producin... | 10/24/2006 |
| 7125717 | Metabolically activated recombinant viral vectors and methods for their preparation and use Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of... | 10/24/2006 |
| 7125549 | Methods and compositions for efficient gene transfer using transcomplementary vectors The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a recipient cell. The two vectors complement each other and thus allow viral r... | 10/24/2006 |
| 7117095 | Methods for selecting nucleic acid probes Methods and computer software products are provided for selecting nucleic acid probes. In one embodiment, dynamic programming is employed to select a set of k probes from n probes so that the selected probes have a maximum aggregate adjusted quality score. ... | 10/03/2006 |
| 7105346 | Packaging systems for human recombinant adenovirus to be used in gene therapy Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinan... | 09/12/2006 |
| 7094604 | Production of pseudotyped recombinant AAV virions Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyp... | 08/22/2006 |
| 7094398 | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration The present invention provides for novel chimeric Ad-vectors carrying transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or αυβ3/5-independent manner. Also provided ar... | 08/22/2006 |
| 7091029 | High titer recombinant AAV production The invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (rAAV). The disclosed rAAV are useful in gene therapy applications. Methods are based on the use of recombinant herpes virus vectors and result in hig... | 08/15/2006 |
| 7078030 | Oncolytic adenovirus Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promote... | 07/18/2006 |
| 7078218 | Alphavirus particles and methods for preparation Provided herein are methods for producing alphavirus replicon particles in high yield; replicon RNAs are electroporated into permissive cells, where the cells are at a relatively high density, together with at least one helper nucleic acid providing the necessary fu... | 07/18/2006 |
| 7070998 | Adeno-associated virus materials and methods The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines produci... | 07/04/2006 |
| 7070993 | Lentiviral packaging constructs The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present invention provides novel packaging cell lines that are capable of constituti... | 07/04/2006 |
| 7060497 | Adeno-associated viral vector-based methods and compositions for introducing an expression cassette into a cell Methods and compositions are provided for introducing an expression cassette into a cell. In the subject methods, a population of at least two distinct adeno-associated viral particles is provided, where each distinct type of viral particle in the population compris... | 06/13/2006 |
| 7056502 | Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any cross-reactive serotype of the AAV ITRs are utilized. A similar method... | 06/06/2006 |
| 7052881 | Packaging systems for human recombinant adenovirus to be used in gene therapy Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large-scale production of recombinan... | 05/30/2006 |
| 7052904 | Hybrid adeno-retroviral vector for the transfection of cells An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid sequence, a nucleic acid sequence encoding a portion of a retroviral enve... | 05/30/2006 |
| 7052692 | Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularl... | 05/30/2006 |
| 7037723 | Recombinant herpes viruses for preparing recombinant adeno-associated viruses The invention relates to a recombinant herpes virus which contains the rep and cap genes of the adeno-associated virus, and to a method for producing high-titer, highly infectious adeno-associated virus vector preparations. ... | 05/02/2006 |
| 6995006 | Methods for generating high titer helper-free preparations of released recombinant AAV vectors This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this in... | 02/07/2006 |
| 6995010 | Gene transfer method A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of... | 02/07/2006 |
| 6979568 | Vector for the expression of two foreign genes A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be provided as a lentivirus vector based on SIVagm, is constructed by modifying... | 12/27/2005 |
| 6955919 | Lentiviral packaging cells and uses therefor Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 10/18/2005 |
| 6951753 | Helper-free stocks of recombinant adeno-associated virus vectors A method for producing helper-free stocks of recombinant adeno-associated virus (rAAV) which can be used to efficiently and stably transduce foreign genes into host cells or organisms. The method comprises the cotransfection of eukaryotic cells with rAAV and with he... | 10/04/2005 |
| 6951758 | Helper virus-free AAV production A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection wit... | 10/04/2005 |
| 6946126 | Replicating adenovirus vectors The present invention provides replicating [100K−] adenovirus vectors that have an impairment in 100K activity. In particular preferred embodiments, the impairment is the result of a deletion in the 100K coding region of the adenovirus vector genome. It is further... | 09/20/2005 |
| 6943015 | Large scale production of packaged alphavirus replicons Large-scale packaging of alphavirus replicons is accomplished by co-transfecting host cells with three RNA molecules: (1) an alphavirus replicon comprising a sequence encoding a heterologous protein; (2) a helper RNA encoding a capsid protein and (3) a helper RNA en... | 09/13/2005 |
| 6943012 | Helper dependent adenoviral vector system and methods for using the same A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human stuffer DNA that provides for in vivo long term, high level expression o... | 09/13/2005 |
| 6936466 | Transcriptionally-activated AAV inverted terminal repeats (ITRs) for use with recombinant AAV vectors This invention provides transcriptionally-activated AAV ITRs (inverted terminal repeats) which are small and transcriptionally active and uses thereof to optimize the expression of relatively large transgenes packaged in recombinant AAV vectors. ... | 08/30/2005 |
