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| Number | Title | Issue Date |
| 8163557 | Chimaeric human papillomavirus 16 L1 virus-like particles and a method for preparing the particles A method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide comprising the steps of introducing a DNA sequence coding for the heterologous peptide into a DNA sequence coding for ... | 04/24/2012 |
| 8133878 | Methods for treating restenosis Restenosis in a subject can be treated by administering to a tissue, e.g., a blood vessel, of the subject an agent that increases SERCA activity. For example, a stent that is coated with the agent can be introduced into a blood vessel. ... | 03/13/2012 |
| 8093054 | Metabolically activated recombinant viral vectors and methods for their preparation and use Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors; capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of... | 01/10/2012 |
| 8043856 | Adenoviral vectors for influenza virus production The invention provides adenovirus and retrovirus vectors useful to prepare influenza virus. Also provided is a canine RNA polymerase I promoter and vectors having that promoter. ... | 10/25/2011 |
| 7939326 | Methods and compositions for enhancing cell adhesion properties The present invention provides a modified cell having adhesion properties that are increased as compared to the adhesion properties of an unmodified cell, comprising a) a recombinant nucleic acid encoding an integrin β3 subunit; b) a recombinant nucleic ... | 05/10/2011 |
| 7871819 | Regulatory constructs comprising intron 3 of prostate specific membrane antigen gene The invention provides a recombinant vector comprising an ovine adenovirus genome and a sequence encoding a heterologous polypeptide, wherein the sequence encoding the heterologous polypeptide is inserted between E4 and E3 transcription units of the ovine adenovirus... | 01/18/2011 |
| 7846729 | Metabolically activated recombinant viral vectors and methods for their preparation and use Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of... | 12/07/2010 |
| 7820440 | Means and methods for producing adenovirus vectors The invention relates to methods and means for producing adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenoviral vector and wherein the E4-orf6 gene product is compa... | 10/26/2010 |
| 7803622 | Adeno-associated virus vectors The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persiste... | 09/28/2010 |
| 7785887 | Adenovirus E1B-55K single amino acid mutants and methods of use Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer... | 08/31/2010 |
| 7785888 | Metabolically activated recombinant viral vectors and methods for their preparation and use Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of... | 08/31/2010 |
| 7655467 | Compositions and methods for systemic nucleic acid sequence delivery The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such ... | 02/02/2010 |
| 7651857 | Methods for enhancing antigen presentation We describe (1) a method of enhancing antigen presentation, comprising the step of supplying to an antigen presenting cell such as a dendritic cell, or precursor cell, an inhibitor of Toll-related receptor (TRR) signalling and (2) a method of inhibiting antigen pres... | 01/26/2010 |
| 7638333 | Anthrax vaccine Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described. ... | 12/29/2009 |
| 7465583 | Duplexed parvovirus vectors The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further d... | 12/16/2008 |
| 7439065 | Helper virus-free AAV production A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection wit... | 10/21/2008 |
| 7439066 | Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelo... | 10/21/2008 |
| 7419829 | Vector system The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. T... | 09/02/2008 |
| 7416890 | Baculovirus vector, method of producing thereof and method of gene transfer The present invention provides a novel baculovirus vector which can provide a desired protein not requiring infectivity to insect cells, on the viral particle surface; method of producing thereof; and method of gene transfer using the baculovirus vector. A method of... | 08/26/2008 |
| 7407801 | Truncated CMV promoters and vectors containing same The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to transgenes of interest, including those encoding partially-deleted CFT... | 08/05/2008 |
| 7407807 | Chimaeric human papillomavirus 16 I1 virus like particles and a method for preparing the particles The invention describes a method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide. The method comprises the steps of introducing a DNA sequence coding for the heterologous pept... | 08/05/2008 |
| 7405038 | Stable cell lines resistant to apoptosis and nutrient stress and methods of making same Cell lines that are commonly used for protein expression are engineered to include genes that encode suppressors of apoptosis (SA). Insect cell lines expressing these SA genes are resistant to apoptosis or programmed cell death, and express certain recombinant prote... | 07/29/2008 |
| 7402436 | Lentiviral vectors for site-specific gene insertion Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vi... | 07/22/2008 |
| 7393677 | Avidin-pseudotyped viral vectors and their use The present invention pertains to an avidin-pseudotyped virus, and especially baculovirus, useful for delivery of foreign genes etc. The present invention also pertains to vectors comprising respective cassettes for pseudotyping, mammalian gene expression and insect... | 07/01/2008 |
| 7371374 | Neural transplantation using pluripotent neuroepithelial cells The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods f... | 05/13/2008 |
| 7361496 | Rescue of mumps virus from cDNA This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the mumps virus... | 04/22/2008 |
| 7351877 | Lambda integrase mediated recombination in plants The present disclosure provides methods for obtaining the targeted integration of a DNA molecule into the genome of a host cell using a recombinase. The methods disclosed herein can be used with a variety of host cells, including, for example, dicotyledonous and mon... | 04/01/2008 |
| 7351697 | Tumor-specific vector for gene therapy The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence thereof. The gene is controlled by the promoter for the catalytic subunit ... | 04/01/2008 |
| 7351585 | Retroviral vector Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell. ... | 04/01/2008 |
| 7348138 | Method of inducing cell death using West Nile virus capsid protein This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from... | 03/25/2008 |
| 7348178 | Recombinant adenoviral vector system The present invention relates to a novel Ad based packaging system that can be used for incorporation of heterologous DNA into infectious but replication defective viral particles. The components of the invention include an “artificial genome”, i.e., a recombina... | 03/25/2008 |
| 7335353 | Porcine cells comprising an adenovirus E3 gene region The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of... | 02/26/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7332322 | Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof The present invention provides a Venezuelan equine encephalitis virus replicon RNA useful in the development of stable lines of mammalian, avian and insect cells in which these replicons will persistently replicate. Venezuelan equine encephalitis (VEE) virus replico... | 02/19/2008 |
| 7332338 | Vectors for making genomic modifications Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow ... | 02/19/2008 |
| 7332337 | Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a viral particle containing a modified viral coat proteins containing adeno... | 02/19/2008 |
| 7323177 | Recombinant porcine adenovirus vector This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determina... | 01/29/2008 |
| 7323619 | Method for producing transgenic birds and fish The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest. ... | 01/29/2008 |
| 7323337 | Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors Highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein, which is a surface glycoprotein of vesicular stomatitis virus (VSV) The... | 01/29/2008 |
| 7323297 | Stabilized polynucleotide complexes and methods The invention comprises stabilized polynucleotide complexes that have a cryoprotectant and are lyophilized. Cryoprotectant compounds comprise carbohydrates or sugars, preferably lactose and sucrose, but also glucose, maltodextrins, mannitol, sorbitol, trehalose, and... | 01/29/2008 |
