Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8187884 | Method of enhancing homologous recombination of somatic cells and method of constructing specific antibody The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. By putting immunocytes in which DNA homologous recombination is occurrin... | 05/29/2012 |
| 8187883 | Method and system for delivering nucleic acid into a target cell Controlled delivery of nucleic acid into target cells is achieved by immobilizing the nucleic acid and the cells to a substrate. Improved control over delivery is achieved by immobilizing the nucleic acid to the substrate via complementary DNA binding interactions w... | 05/29/2012 |
| 8183044 | Recombinant human hepatitis C virus-like particle and method for producing the same The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5′ untranslated region, the nucleotid... | 05/22/2012 |
| 8173428 | LNA oligonucleotides and the treatment of cancer The present disclosure concerns LNA oligonucleotides having a (sub)sequence of the general formula 5′-(MeCx)(Tx)MeCxAsAstscscsast... | 05/08/2012 |
| 8158361 | Tumor marker The present invention concerns a gene product largely homologous to the epithelial growth factor receptor (EGFR). It further refers to mRNA coding for such epithelial growth factor receptor. The present invention provides such an epithelial growth factor receptor wh... | 04/17/2012 |
| 8153432 | Multiplex automated genome engineering The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells. ... | 04/10/2012 |
| 8153433 | Mammalian cell lines for increasing longevity and protein yield from a cell culture Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hamiones, an... | 04/10/2012 |
| 8148154 | Method for preparation of single chain antibodies This invention provides a method for identifying cells expressing a target single chain antibody (scFv) directed against a target antigen from a collection of cells that includes cells that do not express the target scFv, comprising the step of combining the collect... | 04/03/2012 |
| 8137974 | Transposition of maize AC/DS elements in vertebrates The present invention is directed to the use of the maize Ac/Ds transposable elements in vertebrates. ... | 03/20/2012 |
| 8133733 | Nonviral vectors for delivering polynucleotides to target tissues Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. ... | 03/13/2012 |
| 8114849 | Retinal dystrophy-associated protein and uses thereof Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syn... | 02/14/2012 |
| 8080420 | Methods and products for biasing cellular development Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, huma... | 12/20/2011 |
| 8076307 | Formation/elongation of axon by inhibiting the expression or function of Singar and application to nerve regeneration Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expres... | 12/13/2011 |
| 8076140 | Mammalian cell lines for increasing longevity and protein yield from a cell culture Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, an... | 12/13/2011 |
| 8076139 | Processes and compositions for transfecting Chinese hamster ovary (CHO) cells The present invention generally relates to processes and compositions for the transfection of Chinese hamster ovary (CHO) cells. More specifically, the present invention relates to processes for the transfection of CHO cells suspended in an aqueous medium using a tr... | 12/13/2011 |
| 8048675 | Integration-free human induced pluripotent stem cells from blood Provided herein are methods for generating human induced pluripotent stem cells free from genomic integration of exogenous transgenes by transfecting into nucleated blood cells one or more DNA expression vectors (e.g., plasmid vectors) that do not contain a mammalia... | 11/01/2011 |
| 8043855 | Recombinant adenoviral vectors and their utility in the treatment of various types of fibrosis: hepatic, renal, pulmonary, as well as hypertrophic scars The invention encompasses the use of gene therapy for the treatment of different kinds of fibrosis in human beings. Specifically, the invention encompasses the use of therapeutic genes specifically directed to target organs to revert and/or prevent the development o... | 10/25/2011 |
| 8039445 | Methods and devices for delivering a therapeutic product to the ocular sphere of a subject The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or ... | 10/18/2011 |
| 8039261 | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed. ... | 10/18/2011 |
| 8034619 | Polyamides for nucleic acid delivery The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA conta... | 10/11/2011 |
| 8030074 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 10/04/2011 |
| 8026097 | Expansion of NK cells and therapeutic uses thereof The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.... | 09/27/2011 |
| 8017398 | Method for assaying protein-protein interaction The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first prot... | 09/13/2011 |
| 8008077 | Photochemical internalization for delivery of molecules into the cytosol The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitising agent, the cell is irradiated with light of a wavelength effective to activate the photosensitising agent and, substa... | 08/30/2011 |
| 8008076 | Method of producing a nucleic acid encoding an antibody An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of... | 08/30/2011 |
| 7993924 | cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids ... | 08/09/2011 |
| 7993925 | Methods for producing microRNAs The invention relates to recombinant vectors for inducible and/or tissue specific expression of double-stranded RNA molecules that interfere with the expression of a target gene. In certain embodiments, the invention relates to the use of Tet (tetracycline)-responsi... | 08/09/2011 |
| 7981674 | Osteoactivin protein and nucleic acids encoding the same, compositions and methods of stimulating bone differentiation The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. T... | 07/19/2011 |
| 7981675 | LITAF binding site peptides and methods of using the same The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-α factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL (SEQ ID NO: 5), or homologs t... | 07/19/2011 |
| 7981676 | Method for transfer of molecular substances with prokaryotic nucleic acid-binding proteins The invention relates to a method for the transfer of molecular substances, for example proteins or nucleic acids in cells, in the case of using DNA combined with a possible gene expression. A prokaryotic nucleic acid-binding protein is used for the transfer, which ... | 07/19/2011 |
| 7977097 | Method of screening multiply transformed cells using bicistronic expression of fluorescent proteins A method of screening multiply transformed/transfected cells to identify those cells expressing at least two peptides or proteins of interest. The method comprising: 1. Simultaneously or sequentially transforming a cell with at least two different expression cassett... | 07/12/2011 |
| 7964406 | Means and methods for producing a stabilized cell of interest The invention provides a method for producing a stabilized cell of interest, said method comprising providing a stem cell and/or a precursor cell of said cell of interest with a nucleic acid sequence which, when present in said cell of interest, is capable of stabil... | 06/21/2011 |
| 7943378 | Tissue engineering The present invention relates, in general, to tissue engineering and, in particular, to a method of extending the lifespan of cells suitable for use in vascular engineering. ... | 05/17/2011 |
| 7935531 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The de... | 05/03/2011 |
| 7932087 | Method of expressing recombinant protein in CHO cells Method of expressing recombinant protein in CHO cells, by using an expression vector comprising the murine IgG 2A gene locus. ... | 04/26/2011 |
| 7927873 | Polyamides for nucleic acid delivery The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potentia... | 04/19/2011 |
| 7923250 | Methods of expressing LIM mineralization protein in non-osseous cells Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus pulposus) are described. The methods involve transfecting the cells with an... | 04/12/2011 |
| 7915230 | Reagents for transfection of eukaryotic cells Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as c... | 03/29/2011 |
| 7910567 | Opticin nucleic acid administration reduces blood vessel formation The invention relates to the use of an agent that promotes class III SLRP activity in the manufacture of a medicament for the inhibition of blood vessel formation. In addition the invention relates to the use of an agent that promotes class III SLRP activity in the ... | 03/22/2011 |
| 7910370 | Methods of using BCL-2 for the therapeutic treatment and prevention of diseases The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the disease or pathological condition. Diseases or pathological conditions ca... | 03/22/2011 |
