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| Number | Title | Issue Date |
| 7915044 | Electrofusion microelectrode and methods of using it to manipulate cells and/or cellular components The present invention relates to an electrofusion microelectrode made of a tube having a first proximal end and a second distal end. The tube has an electrically conductive coating on its exterior surface that extends continually from the first proximal end of the t... | 03/29/2011 |
| 7427503 | Method for transferring material in a cell system Described is a method for method for transferring material through the membrane of at least one cell, wherein the transfer is carried out in the presence of trehalose. This method is applicable in particular in the field of genetic engineering and biotechnology.... | 09/23/2008 |
| 7405080 | Compositions and methods relating to prevention of chemotherapy-induced alopecia The present invention relates to a method for protecting a human patient or a mammalian animal to be subjected to chemotherapy treatment of a tumor not residing in the scalp of the patient or the skin of the animal against chemotherapy-induced alopecia, comprising a... | 07/29/2008 |
| 7387873 | Human myeloma cell line There is provided a human myeloma cell tine for use in a method for producing a human monoclonal antibody. ... | 06/17/2008 |
| 7376117 | Interleaving circuit for a multiband OFDM transceiver Interleaving circuit for a multiband OFDM (orthogonal frequency division multiplexing) transceiver of a ultra wide band wireless personal access network transmitting OFDM modulated symbols, wherein each OFDM symbol consists of a predetermined number (NCBPS | 05/20/2008 |
| 7341864 | Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method A molecule introducing apparatus is provided with a power supply circuit 20 for supplying power, a step-up transformer 30 which is supplied with power from the power supply circuit 20 and which outputs a high voltage, a switching transistor 2... | 03/11/2008 |
| 7319004 | Materials and methods relating to polyions and substance delivery Materials and method are disclose for delivering a desired substance to a target site, using a layered carrier in which the carrier and the substance together form at least three layers which associate by ionic interaction at the first pH, where at least one layer c... | 01/15/2008 |
| 7201898 | Methods and compounds for controlled release of recombinant parvovirus vectors The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeuti... | 04/10/2007 |
| 7169282 | Dielectrophoresis apparatus Devices for filtering fluids using dielectrophoresis are disclosed. ... | 01/30/2007 |
| 7157257 | Method of treating biological cells and/or their cell components with electrical fields A method is described for treating biological cells and/or their cell components with electrical fields in a reaction medium, in which an inhibitor is added to the reaction medium to counteract the action of enzymes that break down protein. ... | 01/02/2007 |
| 7136699 | Apparatus for destroying dividing cells An apparatus is provided for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the dividing cells are connected ... | 11/14/2006 |
| 7133725 | Method and related composition employing nanostructures A composition of microscopic devices utilizable in a medical diagnostic or therapeutic procedure. Each microscopic device includes a nanostructure provided with a ligand for effectively coupling the nanostructure to a predetermined chemical or molecular site. A medi... | 11/07/2006 |
| 7101703 | Electrofusion microelectrode The present invention is directed to an electrofusion microelectrode used in the alignment, manipulation, fusion, or electroporation of cells. This device is particularly useful for transplantation of cells and cellular components. ... | 09/05/2006 |
| 7098030 | Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav... | 08/29/2006 |
| 7094605 | Formation of polyampholytes in the presence of a polyion Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic... | 08/22/2006 |
| 7056332 | Nucleic acid biomaterials and methods of formation and use Polymers that are biocompatible are useful for various medical purposes such as tissue repair, reconstruction and wound healing. A method and composition for producing a biocompatible polymer formed from nucleic acids is disclosed. The nucleic acid polymer may be us... | 06/06/2006 |
| 7018819 | Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof An apparatus and method are disclosed for electromanipulation of at least one cell or cell-like structure having cell-like membranes, the method comprising the steps: (a) at least one cell or cell-like structure is transported from one or more sample containers loca... | 03/28/2006 |
| 7016725 | Method and apparatus for destroying dividing cells The present invention provides a method and apparatus for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the ... | 03/21/2006 |
| 7008787 | Chamber for the treating cells contained in a suspension in an electric field A chamber for treating cells contained in a suspension in an electric field, the chamber having a vessel for holding the suspension and at least two electrodes with electrode surfaces that face each other. The suspension may be placed between the electrode surfaces ... | 03/07/2006 |
| 6995252 | PT32 sperm protein, sperm c-Yes, oocyte cytoplasmic c-Yes and uses thereof The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abno... | 02/07/2006 |
| 6939712 | Muting gene activity using a transgenic nucleic acid The invention provides compositions and methods for muting expression of an endogenous gene in an animal cell, the muting resulting from providing a transgene to a cell. Expression of which transgene is undetectable. The transgene comprises the muting nucleic acid, ... | 09/06/2005 |
| 6929949 | Corona ion generating method and apparatus for the manipulation of molecules and biological cells The present invention provides a method and apparatus adapted to facilitate the entry of a preselected molecule into the intracellular space of a cellular sample through the use of ions generated by a corona charge source. With the present method and apparatus, mole... | 08/16/2005 |
| 6919091 | Compositions and methods for drug delivery using pH sensitive molecules An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav... | 07/19/2005 |
| 6916656 | Non-linear amplitude dielectrophoresis waveform for cell fusion An object of the invention is to provide a method of treating biological cells prior to subjecting the biological cells to cell fusion pulses which includes the step of treating the biological cells with pre-fusion electric field waveforms which change amplitude in ... | 07/12/2005 |
| 6794189 | Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav... | 09/21/2004 |
| 6733761 | Mycobacterial isocitrate lyase gene and uses thereof The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated isocitrate lyase proteins and mutated isocitrate lyase proteins. Add... | 05/11/2004 |
| 6623964 | Method for treatment of an aqueous flux by electropulsation of a field parallel to the flow, pulsation chamber and uses thereof The invention concerns a method for treating an aqueous flow colonized by cells with a pulsed electric field applied to a flow, characterized in that the applied field is substantially parallel to the direction of flow and to its application to the transf... | 09/23/2003 |
| 6586584 | Sequences and methods for detection of Hepatitis C virus Primers and probes derived from the 5' untranslated region of the HCV genome which facilitate detection and/or quantification of all presently known genotypes of HCV. Disclosed sequences may be used in a variety of primer and probe constructs for amplific... | 07/01/2003 |
| 6531646 | Strain manipulation and improvement in the edible seaweed Porphyra A method for the genetic modification and improvement of Porphyra species utilizing protoplast fusion is disclosed. The method of the invention features the use of conchoporangial branch conchocelis for at least one of the sources of protoplasts for proto... | 03/11/2003 |
| 6492175 | Microsystem for cell permeation and cell fusion An electroporation and/or fusion treatment of microscopic objects occurs in a medium between at least two electrodes, with the electrodes being miniaturized electrodes in a microsystem with a channel structure which is set up for the flow-through of the m... | 12/10/2002 |
| 6383811 | Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to... | 05/07/2002 |
| 6355485 | Electrofusion chamber A new and useful apparatus for producing cell electrofusion is provided. The apparatus comprises: a. a chamber with a substrate disposed therein, b. means for directing the cells to be fused toward one side of the substrate; and c. a device for inducing fusion... | 03/12/2002 |
| 6333194 | Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof The invention relates to compositions and methods for delivering a virus vector to an animal. The compositions include compositions which comprise a hydrogel matrix (e.g. a collagen matrix which can comprise a poloxamer or an alginate) containing a virus ... | 12/25/2001 |
| 6297025 | Measurement of complete electrical waveforms of tissue or cells A method of observing a physical and chemical property of a tissue or cell by using an apparatus which comprises at least a cell culturing means, an environment conditioning means, an observing means and a comparing means, comprising the steps of (A) cult... | 10/02/2001 |
| 6221665 | Electrofusion chamber A new and useful apparatus for producing cell electrofusion is provided. The apparatus comprises: a. a chamber with a substrate disposed therein, b. means for directing the cells to be fused toward one side of the substrate in so that the cells in the fluid me... | 04/24/2001 |
| 6143564 | Use of the polar body chromosomes for the production of embryos and normal offspring The invention provides a method for obtaining a live offspring having maternal chromosomes derived from a live first polar body of an oocyte that has completed the first meiotic division. It has been discovered herein that chromosomes in the first polar b... | 11/07/2000 |
| 6107543 | Culture of totipotent embryonic inner cells mass cells and production of bovine animals The use of totipotent embryonic stem cells to provide substantially identical cells for embryo cloning techniques is described. The method includes the culture of loose suspensions of inner cell mass cells of bovine animals to retrieve large populations o... | 08/22/2000 |
| 5989901 | Computer system for controlling value of operational parameters during an operation A computer system for controlling the parameters used during molecule transfer operations. The computer system includes a processor coupled to a memory. The memory stores instructions that are executed by the processor. The computer system controls the va... | 11/23/1999 |
| 5843754 | Parthenogenic bovine oocyte activation A process of parthenogenic activation of mammalian oocytes which includes increasing intercellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducin... | 12/01/1998 |
| 5650305 | Method to produce hybrid cells by electrofusion A method and apparatus for electrofusing a cell pellet comprising a plurality of tiers of cells of two different cell types to be fused which results in the formation of hybrid cells with high efficiency and high viability. The method comprises subjecting... | 07/22/1997 |
