Class 435/446 - Mutation employing radiation or electricity

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Processes wherein structural change in a gene is effected
No. of patents: 27
Last issue date: 02/26/2008

Number	Title	Issue Date
7335258	Functionalization and separation of nanotubes and structures formed thereby Methods of forming a microelectronic structure are described. Embodiments of those methods include attaching at least one functional group to a chondroitin sulfate molecule, and then attaching the at least one functional group to a carbon nanotube, wherein the carbo...	02/26/2008
7320675	Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid ...	01/22/2008
7208317	In Vitro mutagenesis, phenotyping, and gene mapping Cellular libraries useful for in vitro phenotyping and gene mapping. In a representative approach, a method for preparing a homozygous cellular library includes the steps of providing a heterozygous cellular library comprising a plurality of isolated parent cells; i...	04/24/2007
RE39352	Creatine amidinohydrolase, production thereof and use thereof A creatine amidinohydrolase having the following physicochemical properties: Action: catalyzing the following reaction; creatine+H2O→sarcosine+urea ...	10/17/2006
7118894	Bacterial strains, methods of preparing the same and use thereof in fermentation processes for L-lysine production The invention provides novel microorganisms, methods for the production thereof and novel processes for the production of amino acids. Mutagenesis of parental bacterial strains and selection of an improved raffinate-resistant phenotype enables the isolation of strai...	10/10/2006
7049110	Inactivation of West Nile virus and malaria using photosensitizers Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic a...	05/23/2006
6835867	Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)...	12/28/2004
6733761	Mycobacterial isocitrate lyase gene and uses thereof The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated isocitrate lyase proteins and mutated isocitrate lyase proteins. Add...	05/11/2004
6696294	Methods for generating and identifying mutant polyploid plants, and uses therefor The present invention provides methods for generating and identifying mutations in any target gene of a polyploid plant species. In a preferred aspect of the present invention, a plant is constructed and/or selected that has at least one copy of a functio...	02/24/2004
6599705	Regulation of fungal gene expression Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods....	07/29/2003
6468745	Method for expressing a library of nucleic acid sequence variants and selecting desired traits The present invention relates to a method for using viral vectors to bear populations of sequence variants and using plant hosts to select the sequences that exhibit the desired traits....	10/22/2002
6261825	Production of amino acids using auxotrophic mutants of methylotrophic bacillus A method of producing amino acids by culturing an amino acid auxotroph of a biologically pure strain of a type I methylotrophic bacterium of the genus Bacillus which exhibits sustained growth at 50° C. using methanol as a carbon and energy source and req...	07/17/2001
6248516	Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, prefer...	06/19/2001
6156509	Method of increasing efficiency of directed evolution of a gene using phagemid An improved method of mutanting DNA is provided comprising mutating a gene bearing phagemid in a host and infecting the host cell with a suitable helper phage to initiate packaging of the DNA into a phagemid. The packaged phagemid is then used to infect a...	12/05/2000
6060315	Method for facilitating the introduction of material into cells The present invention is a method for creating a localized disruption within a boundary of a cell or structure by exposing a boundary of a cell or structure to a set of energetically charged particles while regulating the energy of the charged particles s...	05/09/2000
5994075	Methods for identifying a mutation in a gene of interest without a phenotypic guide The invention encompasses methods of identifying a mutation in a gene of interest in an organism which include identifying in a test DNA sample from a mutated organism a mutation in a gene of interest without the prior observation of a phenotypic alterati...	11/30/1999
5994620	Induced chromosomal deletion Disclosed is a method for the production of deletions in the chromosomal DNA of a single eukaryotic cell. More specifically, the method involves the creation of either random chromosomal deletions, or chromosomal deletions within a predetermined genetic l...	11/30/1999
5834182	Method for increasing transduction of cells by adeno-associated virus vectors This invention includes methods for increasing the efficiency of transduction of cells, including non-dividing cells, by recombinant AAV vectors. The methods utilize agents that alter certain aspects of DNA metabolism, more specifically, that affect DNA s...	11/10/1998
5652098	Method for rapid isolation of sensitive mutants Sensitive mammalian cell mutants are rapidly isolated using flow cytometry. A first population of clonal spheroids is established to contain both normal and mutant cells. The population may be naturally occurring or may arise from mutagenized cells. The f...	07/29/1997
5635376	Method for purifying chromosomes and hybrid muntjac cell lines containing foreign chromosomes Introducing a chromosome or chromosome fragment having a size of 25 to 500 Mb and containing a selectable marker into a female muntjac cell which has been immortalized with a nonviral vector, a chemical treatment, or a radiation treatment permits the easy...	06/03/1997
5587290	Stress tolerant yeast mutants The invention provides methods and compositions relating to stress tolerant yeast; in particular, yeast mutants deficient in the expression of functional ATH1 gene product (Ath1p). Such yeast have enhanced tolerance to dehydration and freezing, are able t...	12/24/1996
5240840	DNA superfragment cloning Superfragments of chromosomal DNA having 1 million to 100 million base pairs may be formed by irradiating microcells containing a chromosome with a high dose of γ-irradiation. Such superfragments are useful for the rapid cloning of genes....	08/31/1993
5079154	Mutant resistant to cell membrane synthesis inhibitor and process for preparing the same A mutant of an extracellular enzyme-producing microorganism belonging to genus Bacillus, which is resistant to a cell membrane synthesis inhibitor, including vancomycin and ristocetin, is disclosed. The cell membrane synthesis inhibitor-resistant mutant c...	01/07/1992
4818679	Method for recovering mutant cells This invention concerns a method for recovering mutant cells which produce a substance in a quantifiably reduced amount relative to wild type cells, and the mutant cells so recovered. The method involves contacting the mutant cells under suitable conditio...	04/04/1989
4568644	Fermentation method producing ethanol Ethanol is the major end product of an anaerobic, thermophilic fermentation process using a mutant strain of bacterium Clostridium thermosaccharolyticum. This organism is capable of converting hexose and pentose carbohydrates to ethanol, acetic and lactic...	02/04/1986
4264737	Method of making genetically stable mutants of vibrio cholerae Incubation of a parent strain of Vibrio cholerae at elevated temperature to produce a hypotoxinogenic variant strain and mutation of the variant strain results in mutant strains which retain the biotype and antigens of the parent strain, and which are gen...	04/28/1981
4070243	Method for distinguishing subpopulations in a population of morphologically indistinguishable cells A method for identification of cell subpopulations in a population of cells which are morphologically alike, based on the ability of selected strains of bacteria to bind to the cell surface when they are brought in close contact. Selected strains of natur...	01/24/1978

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Class 435/446 - Mutation employing radiation or electricity