"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 7833790 | Wound dressings comprising oxidized cellulose and human recombinant collagen A wound dressing composition comprising a human recombinant collagen and an oxidized cellulose. For example, the composition may be in the form of a sponge formed by freeze drying an aqueous dispersion of human recombinant collagen and oxidized regenerated cellulose... | 11/16/2010 |
| 7303897 | Method of preparing polynucleotide fragments for use in shuffling, and shuffling of same The invention relates to a fragmentation process that depends on mismatches between two strands of parental polynucleotides. One embodiment, comprises a method for preparing polynucleotide fragments of DNA comprising formation of heteroduplex molecules by hybridizin... | 12/04/2007 |
| 7288390 | Anti-dual integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-dual integrin antibodies, including isolated nucleic acids that encode at least one anti-dual integrin antibody, dual integrin, vectors, host cells, transgenic animals or plants, and methods of making and usin... | 10/30/2007 |
| 7183107 | Enhanced replication of HCV RNA This invention provides methods of generating cells that stably replicate sub-genomic virus replicons. This invention also provides methods of generating cells that have disabled PKR activity and that stably replicate HCV sub-genomic replicons. The invention also pr... | 02/27/2007 |
| 6835867 | Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)... | 12/28/2004 |
| 6696294 | Methods for generating and identifying mutant polyploid plants, and uses therefor The present invention provides methods for generating and identifying mutations in any target gene of a polyploid plant species. In a preferred aspect of the present invention, a plant is constructed and/or selected that has at least one copy of a functio... | 02/24/2004 |
| 6677432 | Mutations of the C-terminal portion of TGF-ଲ superfamily proteins The invention provides modified proteins and DNAs of the TGF-ଲ superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are d... | 01/13/2004 |
| 6504081 | Methods and uses for transposon-based gene targeting The present invention provides methods which greatly facilitate the rapidity in which cells and transgenic animals with targeted genes may be generated. The invention hastens the investigation of cells and transgenic animals bearing lowered expression of ... | 01/07/2003 |
| 6489458 | DNA-based transposon system for the introduction of nucleic acid into DNA of a cell This invention relates to a system for introducing nucleic acid into the DNA of a cell. The system includes the use of a member of the SB family of transposases (SB) or nucleic acid encoding the transposase and a nucleic acid fragment that includes a nucl... | 12/03/2002 |
| 6428985 | Immunosuppressive structural definition of IL-10 Disclosed is the surprising discovery that a single amino acid provides the demarcation between the immunosuppressive and immunostimulatory properties of the cytokine, IL-10. The present invention thus provides mammalian and human IL-10 genes and polypept... | 08/06/2002 |
| 6300118 | Plasmids comprising a genetically altered feline immunodeficiency virus genome The present invention pertains to the prevention or lessening of disease in cats caused by Feline Immunodeficiency Virus (FIV). Prevention or lessening of disease is understood to mean the amelioration of any symptoms, including immune system disruptions,... | 10/09/2001 |
| 6167264 | Methods for processing an outgoing and an incoming call in a mobile communications system Visitor location register and a method for handling an outgoing and an incoming call in a mobile communications system employing a multinumbering scheme. Signalling originating from a mobile services switching center (MSC) contains in case of a mobile-ori... | 12/26/2000 |
| 6083752 | DNA coding for decarbamylase improved in thermostability and use thereof A DNA fragment coding for a decarbamylase protein improved in thermostability as the result of replacement of at least one base of a DNA fragment coding for a decarbamylase protein derived from a microorganism with another base and the resultant replaceme... | 07/04/2000 |
| 5972705 | Sequence-specific methylation of ribonucleic acid The invention features nucleic acid molecules and methods for use in site-specific methylation of ribonucleotides. The methods of the invention can be used to modulate RNA folding, RNA processing, RNA cleavage, and other processes involving sequence-speci... | 10/26/1999 |
| 5736383 | Preparation of Pichia methanolica auxotrophic mutants Methods for preparing Pichia methanolica cells having auxotrophic mutations are disclosed. The methods comprise the steps of (a) exposing P. methanolica cells to mutagenizing conditions, (b) culturing the cells from step (a) in a rich medium to allow muta... | 04/07/1998 |
| 4618493 | Temperature sensitive strains of bovine viral diarrhoea virus, preparation thereof and vaccines containing them A live bovine viral diarrhoea (BVD) virus vaccine capable of producing immunity in bovines without causing significant side effects comprising a temperature sensitive (ts) mutant of BVD virus which is obtained by mutating a strain of BVD virus with nitrou... | 10/21/1986 |
| 4324860 | Lactate dehydrogenase mutants of Streptococcus mutans Mutant strains have been isolated from Streptococcus mutans strain BHT-2(str) which are characterized by a single point mutation in the structural gene for the enzyme, L(+) lactate dehydrogenase, this enzyme being normally responsible for lactic acid prod... | 04/13/1982 |
| 4211846 | Processes for the manufacture of D(-)-3-hydroxybutyric acid and D(-)-3-hydroxybutyric acid producing mutants The invention relates to a process of manufacturing D(-)-3-hydroxybutyric acid by breeding microorganisms capable of producing said acid in a nutrient medium containing certain specific carbon source; bacterial strains especially suitable in carrying out ... | 07/08/1980 |
| 4138291 | Microbiological methods The invention relates to a method of obtaining selected bacterial strains which can convert an assimilable carbon source selected from carbohydrates, methanol, ethanol, glycerin, carbon dioxide and spent lyes from caprolactam synthesis into poly-(D-3-hydr... | 02/06/1979 |
| 4115197 | Procedure for obtaining penicillium species mutants with improved ability to synthesize mycophenolic acid A procedure for efficiently obtaining higher mycophenolic-acid-producing mutants from mycophenolic-acid-producing strains of the genus Penicillium by selecting mutants which are resistant to polyene antibiotics.... | 09/19/1978 |