Famous Patents
The ice cream cone was invented at the St. Louis Worlds Fair by Ernest Hamwi in 1904. His waffle booth was next to an ice cream vendor who ran short of dishes. Hamwi rolled a waffle to hold ice cream and the cone was born.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7972855 | Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms There are provided microorganisms, for example, Mortierella alpina, having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods o... | 07/05/2011 |
| 7892833 | Using inhibitors of histone deacetylases for the suppression therapy of inherited disease predisposing conditions Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such co... | 02/22/2011 |
| 7323329 | Methods for production of hyaluronic acid, and isolated strains of supercapsulated streptococci Isolated strains of supercapsulated streptococci band at a density of no greater than 1.03 g/cm3 in a Percoll gradient and are capable of producing hyaluronic acid with molecular weight exceeding 6 million Da. Methods of producing high molecular we... | 01/29/2008 |
| 7303897 | Method of preparing polynucleotide fragments for use in shuffling, and shuffling of same The invention relates to a fragmentation process that depends on mismatches between two strands of parental polynucleotides. One embodiment, comprises a method for preparing polynucleotide fragments of DNA comprising formation of heteroduplex molecules by hybridizin... | 12/04/2007 |
| 7220571 | strains which over-produce L-threonine and processes for the production of L-threonine by fermentation The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacterial strains and processes employing these strains for the fermentative production of amino acids such as threonine. ... | 05/22/2007 |
| 7208317 | In Vitro mutagenesis, phenotyping, and gene mapping Cellular libraries useful for in vitro phenotyping and gene mapping. In a representative approach, a method for preparing a homozygous cellular library includes the steps of providing a heterozygous cellular library comprising a plurality of isolated parent cells; i... | 04/24/2007 |
| 7078389 | Chemically modified oligonucleotide for site-directed mutagenesis A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formatio... | 07/18/2006 |
| 6835867 | Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)... | 12/28/2004 |
| 6696294 | Methods for generating and identifying mutant polyploid plants, and uses therefor The present invention provides methods for generating and identifying mutations in any target gene of a polyploid plant species. In a preferred aspect of the present invention, a plant is constructed and/or selected that has at least one copy of a functio... | 02/24/2004 |
| 6537795 | Method and means for the production of hyaluronic acid A method for selecting streptococcus strains capable of producing hyaluronic acid with molecular weight exceeding six million includes the steps of cultivating strains of streptococci individually in culture medium which is free of metal ions which promot... | 03/25/2003 |
| 6303376 | Methods of targeted mutagenesis using triple-helix forming oligonucleotides A high affinity, triplex-forming oligonucleotide and methods for use thereof wherein an oligonucleotide is used to form a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the bindin... | 10/16/2001 |
| 6204006 | Microbial strains producing sphingolipid bases Microbial strains capable of producing enhanced levels of sphingosine, dihydrosphingosine, phytosphingosine and/or derivatives thereof are disclosed. Additionally, there are disclosed methods based on mutagenesis, or other selection techniques, whereby su... | 03/20/2001 |
| 6077516 | Live vaccine against colibacillosis A vaccine for the immunization of domestic fowl, such as turkeys and chickens, against E. coli infections (Colibacillosis) is disclosed which contains an effective amount of a live temperature sensitive mutant of E. coli dispersed in a physiologically acc... | 06/20/2000 |
| 5994075 | Methods for identifying a mutation in a gene of interest without a phenotypic guide The invention encompasses methods of identifying a mutation in a gene of interest in an organism which include identifying in a test DNA sample from a mutated organism a mutation in a gene of interest without the prior observation of a phenotypic alterati... | 11/30/1999 |
| 5948954 | High stability peanut A commercially viable, runner-type peanut cultivar, as well as seeds and plants of the cultivar, agronomically similar to Florunner but having an improved fatty acid profile in the seed oil.... | 09/07/1999 |
| 5849539 | Thymidine kinase-lacking ouabain-resistant chicken hybridoma The thymidine kinase-lacking hybridoma of the invention has resistance to oaubain and an Ig-producing ability and is formed by fusing a chicken B lymphoblast cell with an immunized chicken spleen cell. The hybridoma can be used as parental cell line for c... | 12/15/1998 |
| 5834182 | Method for increasing transduction of cells by adeno-associated virus vectors This invention includes methods for increasing the efficiency of transduction of cells, including non-dividing cells, by recombinant AAV vectors. The methods utilize agents that alter certain aspects of DNA metabolism, more specifically, that affect DNA s... | 11/10/1998 |
| 5770412 | Azido-caprolactam as inhibitor for selecting microorganisms with high lysine productivity A process for producing microorganisms which have increased L-lysine productivity is described. The process makes use of microorganisms of the genera Corynebacterium and Brevibacterium which are resistant to feedback inhibition by 2-azido-&3xb5;-caprolact... | 06/23/1998 |
| 5736383 | Preparation of Pichia methanolica auxotrophic mutants Methods for preparing Pichia methanolica cells having auxotrophic mutations are disclosed. The methods comprise the steps of (a) exposing P. methanolica cells to mutagenizing conditions, (b) culturing the cells from step (a) in a rich medium to allow muta... | 04/07/1998 |
| 5541085 | Method for preparing orphan receptor ligands Methods for obtaining cells that produce a ligand for an orphan receptor and methods for preparing polynucleotide molecules that encode ligands for orphan receptors are disclosed. The methods utilize growth factor-dependent parent cells that are transfect... | 07/30/1996 |
| 5534421 | Production of isoleucine by escherichia coli having isoleucine auxotrophy and no negative feedback inhibition of isoleucine production The present invention provides strains of Escherichia coli which have an isoleucine-tRNA synthetase with an increased Km and no negative feedback inhibition of isoleucine production. These strains are effective for the production of isoleucine in high amo... | 07/09/1996 |
| 5399492 | Polyploid baker's yeasts having a low temperature inactivation property Polyploid yeasts having an lti property are obtained by sporulating a starting polyploid strain of Saccharomyces cerevisiae, selecting at least one segregant having an lti property, backcrossing the selected segregant at least once with another segregant ... | 03/21/1995 |
| 5217883 | Process for producing amino acid Disclosed is a process for producing amino acids such as L-threohine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to ... | 06/08/1993 |
| 5217888 | Yeast with high content of arginine The present invention relates to yeast with a high arginine content which belongs to Kluyveromyces polysporus and has resistance to ethionine.... | 06/08/1993 |
| 5183659 | Protection of equines against Streptococcus equi A new bacterial vaccine to protect susceptible equine against S. equi which causes strangles. The vaccine stimulates a nasopharyngeal immune response in a susceptible equine through the presence of antibody activity in the nasopharyngeal mucus. The vaccin... | 02/02/1993 |
| 5094945 | Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthase, production and use Enhanced resistance to glyphosate, an inhibitor of the aromatic amino acid biosynthesis pathway, is imparted to a glyphosate sensitive host. A mutated aroA gene is employed which expresses 5-enolpyruvyl-3-phosphoshikimate synthase (EC: 2.5.1.19) (ES-3-P ... | 03/10/1992 |
| 5079154 | Mutant resistant to cell membrane synthesis inhibitor and process for preparing the same A mutant of an extracellular enzyme-producing microorganism belonging to genus Bacillus, which is resistant to a cell membrane synthesis inhibitor, including vancomycin and ristocetin, is disclosed. The cell membrane synthesis inhibitor-resistant mutant c... | 01/07/1992 |
| 5079145 | Process for preparing microorganisms used for making phenyl acetyl carlinol (PAC) Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candia flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, t... | 01/07/1992 |
| 5057416 | Supersecreting mutants of Saccharomyces cerevisiae A screening procedure is provided which utilizes a milk clotting assay for selecting supersecreting yeast cells for obtaining high yields of desired polypeptide products. Supersecreting yeast cells are provided as filed with American Type Culture Collecti... | 10/15/1991 |
| 4948733 | Zoogloea transformation using exopoly saccharide non-capsule producing strains Two new bacterial strains designated Zoogloea ramigera 115SL and Zoogloea ramigera 115SLR, a rifampicin resistant derivative of 115SL, have been developed. These strains are derived from the wild type Zoogloea ramigera 115, ATCC 25935. The two new strains... | 08/14/1990 |
| 4946783 | Periplasmic protease mutants of Escherichia coli This invention features a method of isolating a mutant strain of Escherichia coli, having a defective periplasmic protease, the method comprising the steps of: mutagenizing an E. coli cell, wherein the cell comprises: (a) an inner and an outer membrane, (... | 08/07/1990 |
| 4851348 | Biologically pure escherichia coli cell line which is a deoR- mutant and which is more transformation efficient with foreign plasmids than deoR+ escherichia coli cell lines, processes for obtaining these cell lines, methods of use A method for obtaining E. coli cell lines which carry the deoR mutation is described, as well as the cell lines themselves. These cell lines are useful in cell transfection and transformation, as they transfect transform at much higher frequencies than th... | 07/25/1989 |
| 4818679 | Method for recovering mutant cells This invention concerns a method for recovering mutant cells which produce a substance in a quantifiably reduced amount relative to wild type cells, and the mutant cells so recovered. The method involves contacting the mutant cells under suitable conditio... | 04/04/1989 |
| 4681762 | Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype The present invention relates to a vaccine composition for the prevention of infectious diseases comprising an immunogenically-effective amount of a genetically attenuated and stable avirulent bacterial strain derived from a virulent bacterial strain by i... | 07/21/1987 |
| 4568644 | Fermentation method producing ethanol Ethanol is the major end product of an anaerobic, thermophilic fermentation process using a mutant strain of bacterium Clostridium thermosaccharolyticum. This organism is capable of converting hexose and pentose carbohydrates to ethanol, acetic and lactic... | 02/04/1986 |
| 4529697 | Process for producing L-glutamic acid by fermentation A process for producing L-glutamic acid by fermentation is disclosed, which process comprises culturing aerobically in a culture medium a mutant of the genus Brevibacterium or Corynebacterium which has an increased superoxide dismutase activity and is cap... | 07/16/1985 |
| 4456588 | Method of the preparation of improved mutant strain of Bordetella bronchiseptica useful as live attenuated vaccine for prophlaxis of B. bronchiseptica infection A method for the preparation of a new mutant strain of Bordetella bronchiseptica having a plural of hereditary chromosomal markers of at least temperature-sensitivity and urease negative, more particularly a phase I mutant strain of B. bronchiseptica havi... | 06/26/1984 |
| 4375514 | Preparation and use of recombinant plasmids containing genes for alkaline phosphatases PhoA mutant E. coli SB44, prepared by mutation of E. coli HB101 with an N-nitroso compound, can be used to identify and isolate recombinant plasmids into which a phoA gene has been incorporated. These plasmids can be used to transform bacteria which can b... | 03/01/1983 |
| 4362815 | Process for the preparation of defective mutants of microorganisms For the production of 17-C-steroid--propionic acid compounds by microbial side chain degradation on 17-C-side chain steroid substrates wild strain microorganisms selected in predetermined manner are subjected to a multi-stage mutation and selection... | 12/07/1982 |
| 4332899 | Process for producing maltase Maltase is produced by growing a mutant of the yeast strain Saccharomyces italicus capable of growing in a growth medium utilizing sucrose as the carbon source. Mutants of Saccharomyces italicus capable of utilizing sucrose as a carbon source also are pro... | 06/01/1982 |
