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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8105836 | Chemical inhibitors of mismatch repair Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more... | 01/31/2012 |
| 8021883 | Antibiotic-sensitive lactic acid bacteria strains Many probiotic Bifidobacteriacea contains an active tetW that renders the cells resistant to tetracycline. This may present a risk of a horizontal transfer of functional antibiotic genes. The present invention relates to a method of obtaining novel tetracycline-sens... | 09/20/2011 |
| 7759121 | Methods for generating hypermutable yeast Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but ... | 07/20/2010 |
| 7547550 | Tetraploid watermelons producing small fruits Tetraploid watermelon inbreds are disclosed. The invention relates to the seeds and plants of the tetraploid watermelon inbreds, the methods of propagating the tetraploid inbreds through seeds and tissue culture. The invention also relates to methods of producing th... | 06/16/2009 |
| 7368259 | Method for generating diversity The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or... | 05/06/2008 |
| 7323329 | Methods for production of hyaluronic acid, and isolated strains of supercapsulated streptococci Isolated strains of supercapsulated streptococci band at a density of no greater than 1.03 g/cm3 in a Percoll gradient and are capable of producing hyaluronic acid with molecular weight exceeding 6 million Da. Methods of producing high molecular we... | 01/29/2008 |
| 7303897 | Method of preparing polynucleotide fragments for use in shuffling, and shuffling of same The invention relates to a fragmentation process that depends on mismatches between two strands of parental polynucleotides. One embodiment, comprises a method for preparing polynucleotide fragments of DNA comprising formation of heteroduplex molecules by hybridizin... | 12/04/2007 |
| 7279463 | Triple-helix forming oligonucleotides for targeted mutagenesis A high affinity, triplex-forming oligonucleotide and methods for use thereof wherein an oligonucleotide is used to form a triple-stranded nucleic acid molecule with a specific DNA segment of a target DNA molecule. Upon formation of the triplex, the binding of the ol... | 10/09/2007 |
| 7256259 | Methods for ligation of molecules to surfaces The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to ... | 08/14/2007 |
| 7235700 | Process for producing cyclohexenone long-chain alcohols A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R1, R2, and R3 individually represents hydrogen or methyl), ... | 06/26/2007 |
| 7208317 | In Vitro mutagenesis, phenotyping, and gene mapping Cellular libraries useful for in vitro phenotyping and gene mapping. In a representative approach, a method for preparing a homozygous cellular library includes the steps of providing a heterozygous cellular library comprising a plurality of isolated parent cells; i... | 04/24/2007 |
| 7169611 | Programmable genotoxic agents and uses therefor The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cell... | 01/30/2007 |
| 7169964 | Genetic control of organ abscission A method for decreasing the rate of organ or floral abscission is described. The method includes modifying the ARF GAP domain of a gene. In one instance the gene is the NEVERSHED gene. ... | 01/30/2007 |
| 7125695 | Directed evolution of microorganisms The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention a... | 10/24/2006 |
| 7122369 | Bacterial strains, methods of preparing the same and use thereof in fermentation processes for L-lysine production The invention provides novel microorganisms, methods for the production thereof and novel processes for the production of amino acids. Mutagenesis of parental bacterial strains and selection of an improved raffinate-resistant phenotype enables the isolation of strai... | 10/17/2006 |
| 7122339 | Method for generating diversity The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or... | 10/17/2006 |
| RE39352 | Creatine amidinohydrolase, production thereof and use thereof A creatine amidinohydrolase having the following physicochemical properties: Action: catalyzing the following reaction; creatine+H2O→sarcosine+urea ... | 10/17/2006 |
| 7118866 | Heterodimeric receptor libraries using phagemids Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into ... | 10/10/2006 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7033766 | Construction and screening of lantibody display libraries A sublancin peptide variant (lantibody) having a spacer region and a subtilin leader peptide fused to the C-terminal end of the mature sublancin peptide provide an anchoring means for inserting and retaining the lantibody in a host cell wall without affecting the in... | 04/25/2006 |
| 6974884 | Chemical synthesis of reagents for peptide coupling The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphine-borane complexes useful as rea... | 12/13/2005 |
| 6972320 | Ligation method and reagents to form an amide bond Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosp... | 12/06/2005 |
| 6887707 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the... | 05/03/2005 |
| 6878817 | Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are descri... | 04/12/2005 |
| 6875582 | Methods and targets of antibiotic resistance The present invention provides for a method of evolving and selecting cells resistant to a selective agent by inducing directed evolution in continuous culture while applying both a mutagenic and selective agent to the cells to determine the cells having resistance.... | 04/05/2005 |
| 6872562 | Herbicide resistant dinitrogen fixing bacteria and method of use The present invention is directed to herbicide resistant N2 fixing bacteria. The bacteria are useful for effecting N2 fixation, nodulation, growth and yield of herbicide resistant or tolerant leguminous plants treated with herbicide. The bacter... | 03/29/2005 |
| 6869601 | Bacterial mutant BX065 and a method thereof The present invention relates to a mutant bacteria Xanthomonas oryzae pathovar oryzae BXO65 with mutation at a site coding for enzyme shikimate dehydrogenase and a method of producing said mutant and also a method of screening inhibitors of bacterial pathogen... | 03/22/2005 |
| 6835867 | Allelic series of genomic modifications in cells The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid sequence-modifying agents (e.g., chemicals, electromagnetic radiation, etc.)... | 12/28/2004 |
| 6740734 | Bacterial receptor structures Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been se... | 05/25/2004 |
| 6733761 | Mycobacterial isocitrate lyase gene and uses thereof The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated isocitrate lyase proteins and mutated isocitrate lyase proteins. Add... | 05/11/2004 |
| 6713261 | Method for assessing genotoxicity of a compound The invention concerns a method for assessing in vitro the genotoxicity of a compound, which consist in contacting said compound with at least a cell or cell type overexpressing bcl2 protooncogene and/or related anti-apoptotic protein, and observing the genotoxic ef... | 03/30/2004 |
| 6706503 | Directed evolution of microorganisms The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention a... | 03/16/2004 |
| 6696294 | Methods for generating and identifying mutant polyploid plants, and uses therefor The present invention provides methods for generating and identifying mutations in any target gene of a polyploid plant species. In a preferred aspect of the present invention, a plant is constructed and/or selected that has at least one copy of a functio... | 02/24/2004 |
| 6666379 | Method of fabricating a wireless radio frequency identification device A wireless radio frequency identification device is fabricated from a substrate formed to have conductive lines, at least a portion of which comprise an antenna. An integrated circuit chip and a battery are conductively bonded to the conductive lines on t... | 12/23/2003 |
| 6653081 | Methods for monitoring antiretroviral therapy and guiding therapeutic decision in the treatment of HIV/AIDS This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) and further rela... | 11/25/2003 |
| 6632923 | Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof,... | 10/14/2003 |
| 6599705 | Regulation of fungal gene expression Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.... | 07/29/2003 |
| 6548070 | Attenuated strains of mycobacteria Attenuated strains of Mycobacterium, particularly species of the tuberculosis complex, have the mycobacterial cell entry (mce) gene functionally disabled. The gene may be disabled by an insertion into the gene which disrupts the mycobacterial cell entry f... | 04/15/2003 |
| 6537795 | Method and means for the production of hyaluronic acid A method for selecting streptococcus strains capable of producing hyaluronic acid with molecular weight exceeding six million includes the steps of cultivating strains of streptococci individually in culture medium which is free of metal ions which promot... | 03/25/2003 |
| 6531303 | Method of producing geranylgeraniol The invention provides a biological method of producing geranylgeraniol.... | 03/11/2003 |
