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| Number | Title | Issue Date |
| 8153431 | Compositions and methods for making mutations in cell lines and animals The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein ... | 04/10/2012 |
| 8097459 | Methods and compositions for increasing replication capacity of an influenza virus In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vacci... | 01/17/2012 |
| 8088620 | Optimised micro-organism strains for NADPH-consuming biosynthetic pathways The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized i... | 01/03/2012 |
| 8076138 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number... | 12/13/2011 |
| 8048674 | Methods and compositions for cellular and metabolic engineering The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of reco... | 11/01/2011 |
| 7972854 | Methods and compositions for targeted cleavage and recombination Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. ... | 07/05/2011 |
| 7972853 | Compositions and methods for making mutations in cell lines and animals The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein ... | 07/05/2011 |
| 7968340 | Structural protein of adeno-associated virus with modified antigenicity, its production and its use The present invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one modification which brings about a reduction in the antigenicity, its production and use. ... | 06/28/2011 |
| 7968339 | Method of inducing genome reorganization via intracellular activation of thermostable multifrequency DNA-cleaving enzyme The present invention relates to a method for increasing genetic recombination frequency in a genomic DNA and a method for inducing genome rearrangement. Specifically, according to the present invention there are provided: the method for increasing genetic recombina... | 06/28/2011 |
| 7939325 | Method and apparatus for substantially isolating plant tissues The present invention provides methods and devices for the rapid isolation of monocot plant embryos suitable for transformation or tissue culture. The invention includes mechanical devices for substantially isolating plant embryos for use as transformable explants. ... | 05/10/2011 |
| 7939324 | Methods for isolating novel antimicrobial agents from hypermutable mammalian cells Dominant-negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into mammalian cells new cell lines with novel and useful properties can be prepared more efficiently than by relying on the... | 05/10/2011 |
| 7935530 | Polyamides with tail structures capable of binding DNA The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are... | 05/03/2011 |
| 7897394 | Endoplasmic reticulum localization signals The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form. The localization signals are utilized as research tools or are linked to therapeutics. Disclos... | 03/01/2011 |
| 7892832 | Methods for generating hypermutable microbes Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desir... | 02/22/2011 |
| 7888120 | Global regulator of morphogenesis and pathogenicity in dimorphic fungi and uses thereof A method of screening a compound for anti-fungal properties comprising the steps of exposing a test compound to a fungal histidine kinase, and determining whether kinase activity is inhibited, wherein inhibition of kinase activity indicates that the compound has ant... | 02/15/2011 |
| 7879609 | Regulatory segments of the human gene for telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 02/01/2011 |
| 7842503 | Hybrid recombinases for genome manipulation The present invention provides methods to site-specifically manipulate genomes by using hybrid recombinases. Hybrid recombinases comprise a modified catalytic domain from a unidirectional serine phage integrase, fused to a foreign DNA recognition domain. ... | 11/30/2010 |
| 7829338 | Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more... | 11/09/2010 |
| 7795030 | Methods and compositions for cellular and metabolic engineering The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cycles of reco... | 09/14/2010 |
| 7776598 | Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed. ... | 08/17/2010 |
| 7741118 | Synthetic plant genes and method for preparation A method for modifying structural gene sequences to enhance the expression of the protein product is disclosed. Also disclosed are novel structural genes which encode insecticidal proteins of B.t.k. HD-1, B.t.k. HD-73, B.t. tenebrionis, B.t. entomocidus, 2 pr... | 06/22/2010 |
| 7741119 | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental ... | 06/22/2010 |
| 7709260 | Sealing closure of bacterial ghosts by means of bioaffinity interactions The invention relates to a method for preparing closed bacterial ghosts by way of specific interactions between partners of a bioaffinity binding pair, and to the bacterial ghosts which can be obtained in this way. Active compounds can be packed into the closed bact... | 05/04/2010 |
| 7704742 | Method and polynucleotides for determining translational efficiency of a codon A method is disclosed for determining the translational efficiency of an individual codon in a cell. The method includes introducing into the cell a synthetic construct including a reporter polynucleotide fused in frame with a tandem repeat of the individual codon, ... | 04/27/2010 |
| 7666676 | Modulating cancer cell characteristics The hedgehog pathway in cerebellar cancer cells was modulated with siRNA specifically targeted to the shh and gli-I genes. Silencing of the two genes in a medullablastoma cell line transfected with the siRNAs caused significant reduction of mRNA specific for the tar... | 02/23/2010 |
| 7655466 | Production process for munant The invention provides a production process for a high-frequent random mutant of an object exogenous gene, wherein a recombinant expression vector in which a eukaryote promoter, an exogenous DNA sequence, an intron enhancer and 3′HS3/4 enhancer are linked is intro... | 02/02/2010 |
| 7638331 | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery The present invention provides methods and constructs for selectively expressing an Apoptosis-Inducing Gene (AIG) in a population of cells that overexpress cyclooxygenase-2 (COX-2) to induce apoptosis in the cell. To achieve this goal a chimeric gene construct is us... | 12/29/2009 |
| 7629170 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number... | 12/08/2009 |
| 7556965 | Structural protein of adeno-associated virus with modified antigenicity, its production and its use The present invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one modification which brings about a reduction in the antigenicity, its production and use. ... | 07/07/2009 |
| 7547549 | Method to produce a hybrid cell having a single mitochondrial genotype The present invention relates to a method of producing a viable hybrid cell having a single functional mitochondrial population. The method comprises the step of introducing genomic DNA from a mitochondrially depleted donor cell into a recipient cell from which geno... | 06/16/2009 |
| 7544512 | Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs The present invention discloses a method of producing polypeptides, including insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs, by ligating genes in a tandem way. Also disclosed are the recombinant polypeptides produced by such a method. Using the method... | 06/09/2009 |
| 7488600 | Compositions and methods for the identification and selection of nucleic acids and polypeptides This invention relates generally to systems and methods for identifying and selecting, desired proteins or nucleic acid molecules by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based u... | 02/10/2009 |
| 7456020 | Method for modifying chromosomes The present invention provides a simple method for splitting and loss of a chromosome in yeast. The method for modifying a chromosome in yeast includes preparing a linear chromosome splitting vector (1) having a target sequence (a), a marker gene sequence and (C | 11/25/2008 |
| 7435574 | NADH oxidase from The present invention is directed to a new NADH oxidase from Lactobacillus, nucleic acids encoding the NADH oxidase, methods of producing the NADH oxidase, as well as there use in producing improved NADH oxidase enzymes and for producing chrial enantiomer-enr... | 10/14/2008 |
| 7435570 | Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use The invention relates to novel variants of cytochrome P450 oxygenases. These variants have at least one mutation improving their ability to use peroxide as an oxygen donor as compared to the corresponding wild-type enzyme. The variants also have at least one mutati... | 10/14/2008 |
| 7432095 | Formate dehydrogenase tolerant to halogen compounds and process for producing the same The invention provides a formate dehydrogenase having high specific activity, small Km values for formate and NAD, broad temperature and pH ranges of stability, broad temperature and pH ranges for action, and capable of regenerating a coenzyme with good efficiency i... | 10/07/2008 |
| 7432093 | Soluble, functional apoptotic protease-activating factor 1 fragments The structure of a soluble, functional fragment of human Apaf-1 protein having ADP bound thereto is disclosed. The invention includes such soluble, functional fragments of human Apaf-1 and other metazoan Apaf-1 homologs. Also included in the invention are methods of... | 10/07/2008 |
| 7429649 | Modification of lignin biosynthesis The present invention relates to the modification of lignin biosynthesis in plants, using the nucleotide sequences encoding the enzymes 4-coumarate CoA-ligase (4CL), cinnamoyl-CoA reductase (CCR), cinnamyl alcohol dehydrogenase (CAD) of the lignin biosynthetic pathw... | 09/30/2008 |
| 7427498 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PHEX, the transm... | 09/23/2008 |
| 7425530 | Stereoselective preparation of cyclic L-amino acids The invention concerns a method for producing a cyclic L-amino acid of formula (I), characterised in that it consists in reacting a L-diamino acid of formula (II) or an enantiomeric mixture comprising such a L-diamino acid and a corresponding D-diamino acid in varia... | 09/16/2008 |
