Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8187878 | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free cond... | 05/29/2012 |
| 8178349 | Homogeneous neural precursor cells This invention provides pure populations of neural precursor cells, capable of differentiation into neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth condition... | 05/15/2012 |
| 8173426 | Muller cells de-differentiated to cells expressing markers of neural cell progenitors A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce... | 05/08/2012 |
| 8173427 | Method of producing a population of post-mitotic cells of the neutrophil lineage A method is provided for producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the ex vivo steps of: (a) providing a population of cells comprising neutrophil progenitor cells; and (b) culturing the population of cells in an ... | 05/08/2012 |
| 8168429 | Method of amplifying hematopoietic stem cell and hematopoietic progenitor cell The present invention provides useful means in an expansion culture system for a hematopoietic cell (hematopoietic stem cell, hematopoietic progenitor cell). Specifically, the present invention provides a composition for expanding a hematopoietic cell (hematopoietic... | 05/01/2012 |
| 8168606 | RNAi inhibition of alpha-ENaC expression The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. ... | 05/01/2012 |
| 8168430 | Method for preparation of hepatocyte using ES cell This invention relates to an agent for promoting differentiation of an ES cell, preferably an agent for promoting differentiation of an ES cell into a hepatocyte or a prophylactic agent for teratoma, comprising uPA. Furthermore this invention relates to a method of ... | 05/01/2012 |
| 8163553 | Human trophoblast stem cells and use thereof Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different ... | 04/24/2012 |
| 8158421 | Cardiomyocyte differentiation The present invention provides a method of enhancing the efficiency of differentiation of hES cells into cardiomyocytes which method comprises incubating the cells under serum free conditions. The method typically includes providing cells that induce cardiomyocyte d... | 04/17/2012 |
| 8158424 | Primate pluripotent stem cells cultured in medium containing gamma-aminobutyric acid, pipecolic acid and lithium Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an undifferentiated state. It has now been found that high levels of fib... | 04/17/2012 |
| 8158422 | Erythroid cells producing adult-type β-hemoglobin generated from human embryonic stem cells Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions. ... | 04/17/2012 |
| 8158423 | Method of making a hair A method of making a hair, including a step of culturing an undifferentiated cell of a mammal to produce an embryoid body and a step of further culturing the embryoid body is provided, wherein the culturing step is to culture the embryoid body on a three-dimensional... | 04/17/2012 |
| 8153427 | Cardiomyocytes and methods of producing and purifying cardiomyocytes The invention provides methods for producing a culture of cardiomyocytes and cultures of cardiomyocytes. Exemplary methods of producing and cultures of cardiomyocytes include a population of cells including cells having spontaneous and periodic electrical activity, ... | 04/10/2012 |
| 8153428 | Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected dire... | 04/10/2012 |
| 8148151 | Differentiation of primate pluripotent cells to hepatocyte-lineage cells Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cell... | 04/03/2012 |
| 8143060 | Method of assessing the viability of thawed developmentally competent embryos The invention relates to a method of assessing the viability of a thawed cell wherein the cell is a gamete, an embryo, a karyoplast, a putative stem cell population, a stem cell precursor population or a stem cell population. The method includes incubating the thawe... | 03/27/2012 |
| 8143059 | Method for identification of cell growth or differentiation factors The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling cell growth f... | 03/27/2012 |
| 8137968 | Selected endothelial progenitor cells and methods for use The present invention is a method for preparing a substantially pure population of endothelial progenitor cells wherein said cells express Flk-1, CD34, α5β1 integrin fibronectin, and vWF and exhibit an adherent phenotype and methods for using... | 03/20/2012 |
| 8137970 | Methods for inducing the differentiation of hematopoietic stem cells into megakaryocytes and platelets, and gene controlling the differentiation The present invention relates to a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets, more particularly, a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and pla... | 03/20/2012 |
| 8137969 | Neural progenitor cells derived from embryonic stem cells The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells... | 03/20/2012 |
| 8133731 | Production of primate neural stem cells through expression of pax6 A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed. ... | 03/13/2012 |
| 8133729 | Biomimetic urothelium Urothelium is the specialized endothelium that lines much of the mammalian urinary tract. This invention relates to the field of in vitro urothelial culture. Previous methods produce tissue lacking much of the functionality of native urothelium. In this invention, s... | 03/13/2012 |
| 8133730 | Generation of neural stem cells from undifferentiated human embryonic stem cells The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning n... | 03/13/2012 |
| 8133732 | Method of forming myeloid precursor cells from human embryonic stem cells This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured ... | 03/13/2012 |
| 8129187 | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generatin... | 03/06/2012 |
| 8110400 | Culture of mammalian pluripotent stem cells in the presence of hyaluronan induces differentiation into multi-lineage progenitor cells A method for the differentiation of mammalian pluripotent stem (PS) cells into a mortal multi-lineage progenitor cell population is provided which comprises culturing the pluripotent stem cells in the presence of Hyaluronan (HA). The mortal multi-lineage progenitor ... | 02/07/2012 |
| 8105833 | Method for forming organ A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand ... | 01/31/2012 |
| 8105832 | Methods for modifying stem cell characteristics The invention provides a method of up-regulating genes in cultured human bone marrow mesenchymal stem cells, the method comprising culturing the stem cells in a nutrient medium together with cells from a limb of a limb-regenerating animal. In the method, the limb-re... | 01/31/2012 |
| 8093049 | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same ... | 01/10/2012 |
| 8093048 | Methods and compositions for activating regenerative stem cells from bone marrow The present invention provides novel compositions and methods for pharmaceutical or nutraceutical use in an animal, preferably in a human. In one aspect, compositions and methods are provided for activating regenerative stem cells from bone marrow, which can lead to... | 01/10/2012 |
| 8093047 | Induction of myocardial cell from mammalian bone marrow cell or cord blood-derived cell and fat tissue This invention provides a method for differentiating mammalian bone marrow cells or cord blood-derived cells into myocardial precursor cells and/or myocardial cells by culturing said bone marrow cells or cord blood-derived cells with cells isolated from mammalian fa... | 01/10/2012 |
| 8093050 | mTOR inhibtors and mTOR signaling pathway inhibitors induce differentiation of human embryonic stem cells into the osteoblastic lineage Disclosed are a composition for introducing the osteogenic differentiation of human embryonic stem cells and a method for differentiating human embryonic stem cells into an osteoblastic lineage by inhibiting the mTOR signaling pathway. When cultured in the presence ... | 01/10/2012 |
| 8084258 | Manipulation of tissue of organ type using the notch pathway The present invention is directed to methods for altering the fate of a cell, tissue or organ type by altering Notch pathway function in the cell. The invention is further directed to methods for altering the fate of a cell, tissue or organ type by simultaneously ch... | 12/27/2011 |
| 8071375 | Use of IL-6-type cytokines for maturation of oocytes The use of certain IL-6-type cytokines for the in vitro maturation of mammalian oocytes is described. The in vitro matured oocytes may be used in in vitro fertilization protocols. ... | 12/06/2011 |
| 8071377 | Methods for immortalizing cells The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that sup... | 12/06/2011 |
| 8071378 | ZNF206: regulator of embryonic stem cell self-renewal and pluripotency We have identified ZNF206, a novel repressor of human embryonic stem cell (hESC) differentiation. Repressing extra-embryonic endoderm development preserves the pluripotent state of human embryonic stem cells, and, conversely downregulating expression of ZNF206 in hE... | 12/06/2011 |
| 8071376 | Production of oligodendrocytes from placenta-derived stem cells The present invention provides methods and compositions for the production of glial cells and oligodendrocytes from placenta stem cells. The invention further provides for the use of these glia and oligodendrocytes in the treatment of, and intervention in, for examp... | 12/06/2011 |
| 8058243 | Method for treating a brain cancer with ifenprodil A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and mul... | 11/15/2011 |
| 8058064 | Sac-like structure enclosing hematopoietic progenitor cells produced from ES cells and method for preparing blood cells An object of the present invention is to provide a sac-like structure enclosing hematopoietic progenitor cells and a method for preparing the sac-like structure as well as a method for efficiently preparing blood cells such as mature megakaryocytes and platelets fro... | 11/15/2011 |
| 8058065 | Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generatin... | 11/15/2011 |
