Class 435/376 - Method of synchronizing cell division

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the cell cycles of a plurality of
No. of patents: 28
Last issue date: 04/17/2012

Number	Title	Issue Date
8158420	Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5 The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenit...	04/17/2012
8119405	Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production. ...	02/21/2012
8084257	Methods for sorting dimorphic daughter cells This invention relates to methods for distinguishing and sorting cells. In particular it includes methods for distinguishing and sorting post-mitotic and post-meiotic daughter cells into two classes according to differential cellular features. Labeling, tagging, or ...	12/27/2011
7354729	High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the gro...	04/08/2008
7354730	High-throughput assay of hematopoietic stem and progenitor cell proliferation The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminesc...	04/08/2008
7335811	Method for collecting cells in M phase or Gphase and method for nuclear transplantation using the cells Methods for collecting cells in M phase or G1 phase, by which the percentage of M phase or G1 phase cells is higher than that attained by the conventional methods are disclosed. ...	02/26/2008
7311904	Tissue matrices comprising placental stem cells, and methods of making the same A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tis...	12/25/2007
7285288	Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n...	10/23/2007
7030292	Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosm...	04/18/2006
6977244	Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n...	12/20/2005
6969609	Recombinant vector expressing multiple costimulatory molecules and uses thereof The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect...	11/29/2005
6867040	Bioreactor and methods for producing synchronous cells Apparatus and methods are directed to a perfusion culture system in which a rotating bioreactor is used to grow cells in a liquid culture medium, while these cells are attached to an adhesive-treated porous surface. As a result of this arrangement and its rotation, ...	03/15/2005
6753181	Methods and compositions for organ decellularization The invention is directed to methods for producing a decellularized organ or part of an organ. A decellularized organ is produced using an isolated organ mechanically agitated to remove cellular membranes surrounding the isolated organ without destroying the interst...	06/22/2004
6667175	Generation of antigen specific T suppressor cells for treatment of rejection This invention provides a method of generating antigen specific allospecific human suppressor CD8+CD28- T cells. This invention also provides a method of generating xenospecific human suppressor CD8+CD28- T cells. This invention further provides a method ...	12/23/2003
6525243	Unactivated oocytes as cytoplast recipients of quiescent cell nuclei while maintaining correct ploidy A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept ex...	02/25/2003
6465251	Method of promoting b-cell proliferation and activation with CD40 ligand and cyclosporin We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B cells can be obtained from peripheral blood in large number...	10/15/2002
6376244	Methods and compositions for organ decellularization The invention is directed to methods for producing a decellularized organ or part of an organ. A decellularized organ is produced using an isolated organ mechanically agitated to remove cellular membranes surrounding the isolated organ without destroying ...	04/23/2002
6290951	Alteration of the cell cycle in vivo, and particularly for inducing apoptosis of tumor cells A first substance (such as the peptide aldehydes LLnL and LVP) inhibits the function of intracellular proteasome. A second substance (such as ranpirnase) inhibits intracellular protein synthesis or increases intracellular expression of a cyclin-dependent ...	09/18/2001
6248541	Screening under nutrient limited conditions Described herein are methods for obtaining from an initial population of cells a plurality of subpopulations of cells having a similar density by growing samples from the initial population in medium having a limiting nutrient. Also provided are methods f...	06/19/2001
6225044	Method for gene transfer into cells activated from a quiescent state A method is disclosed for gene transfer into a culture of primitive stem cells which comprises a prestimulation step of adding a blocking agent to block at least one inhibitor of a cell cycle of said primitive stem cells. The prestimulation is time-limite...	05/01/2001
6143560	Method of synchronizing epithelial cells into G₀ phase The present invention relates to a method of synchronizing epithelial cells into G0 phase, more specifically, a method of synchronizing epithelial cells into G0 phase characterized by culturing the cells in a synthetic medium for 5 d...	11/07/2000
6118044	Transgenic animal allergy models and methods for their use Transgenic mice which constitutively express an antibody-type molecule encoded by the transgene and which has an IgE heavy chain constant region and is specific for a pre-defined antigen, provide an allergic reaction to that antigen without prior sensitiz...	09/12/2000
6020146	Carcinogenicity testing system The present invention is directed to an in vitro method for detecting the presence of carcinogenic agents....	02/01/2000
5837544	Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase The present invention is directed to novel chimeric proliferation receptor proteins and DNA sequences encoding these proteins where the chimeric proteins are characterized in three general categories. In one category, the novel chimeric proteins comprise ...	11/17/1998
5674750	Continuous selective clonogenic expansion of relatively undifferentiated cells A system is provided for selective clonogenic expansion of relatively undifferentiated cells, including (a) a tube containing a plurality of beads of a size which permits a plurality of the undifferentiated cells to grow thereon, the beads bearing on thei...	10/07/1997
5324654	Method for reversibly increasing proliferation of a non-malignant cell population A method and composition for reversibly increasing the proliferation of cells in vitro. Cell populations are treated in vitro with antisense oligonucleotides to a tumor suppressor gene, such as the retinoblastoma (Rb) gene. Such treatment inhibits express...	06/28/1994
5185260	Method for distinguishing normal and transformed cells using G1 kinase inhibitors A G1 phase kinase inhibitor is applied in a low concentration to a population of normal and transformed mammalian cells. The concentration of G1 phase kinase inhibitor is selected to reversibly arrest normal mammalian cells in the G	02/09/1993
4533635	Process for stimulating the growth of epidermal cells A process for stimulating the growth of human epidermal cells, applications of said process and products applying the said process. A process for stimulating the growth of epidermis cells. The epidermis cells are contacted with an aqueous saline extract (RE) of ...	08/06/1985

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Class 435/376 - Method of synchronizing cell division