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| Number | Title | Issue Date |
| 8148150 | Method for the production of intervertebral disk cell transplants and their use as transplantation material The invention relates to a method for the in vitro production of intervertebral disk cartilage cell transplants from affected intervertebral disk tissue from patients and to the use thereof as transplantation material for the treatment of affected intervertebral dis... | 04/03/2012 |
| 8137967 | In-vitro fertilization systems with spermatozoa separated into X-chromosome and Y-chromosome bearing populations An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that can shorten the time from insemination to cleavage and a portable in... | 03/20/2012 |
| 8129186 | Choroid plexus preparation and uses thereof The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture. ... | 03/06/2012 |
| 8080417 | Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells Methods of ex-vivo expansion and at the same time inhibiting differentiation of stem cells by co-culture with mesenchymal cells, transplantable populations of renewable progenitor and stem cells expanded thereby, and their uses in therapeutic applications. ... | 12/20/2011 |
| 8076136 | Mineralized three-dimensional bone constructs The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector c... | 12/13/2011 |
| 8062888 | High throughput assays for transmissible spongiform encephalopathies (TSE) Stable cell lines which produce the pathological form of PrP after infection with the infectious agent for CJD provide a high throughput assay to identify suitable treatment protocols and compositions. The stable cell lines also provide rich source of infectious CJD... | 11/22/2011 |
| 8048671 | Tissue repair with multipotent cells The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as... | 11/01/2011 |
| 8003387 | In vitro germinal centers The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and ot... | 08/23/2011 |
| 7972849 | Primate pluripotent stem cells produced by somatic cell nuclear transfer Purified totipotent stem cells and pluripotent stems cells derived by somatic cell nuclear transfer are disclosed herein, as well as cell lines, multipotent cells and differentiated cells produced from these stem cells. The stem cells are produced from an enucleated... | 07/05/2011 |
| 7910369 | Culture systems for ex vivo development The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses. ... | 03/22/2011 |
| 7901937 | High throughput bioreactor A continuous flow bioreactor system that includes a bioreactor, an optional post-bioreactor preparation chamber, a cell sorter, and an optional pre-bioreactor preparation chamber in a closed loop, useful for enriching a heterogeneous cell population growing in the b... | 03/08/2011 |
| 7816136 | Method for growing stem cells on genetically modified supporter cells A method for growing stem cells comprising the steps of a providing stem cells with supporters said supporters being genetically modified in order to provide externally regulatable interactions between the supporters and the stem c... | 10/19/2010 |
| 7776596 | Vascularization enhanced graft constructs A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of urinary bladder submucosa and stomach submucosa, and extracts and hydrolysates ther... | 08/17/2010 |
| 7736894 | Method for constructing reconstructed skin The present invention relates to a method for constructing human skin tissue, in which human skin tissue is reconstructed on a body surface of an immunodeficient non-human animal. ... | 06/15/2010 |
| 7732202 | Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells Methods of producing human stem cells are disclosed for parthenogenetically activating human oocytes by manipulation of O2 tension, including manipulation of Ca2+ under high O2 tension and contacting oocytes with serine threonine kin... | 06/08/2010 |
| 7709257 | Models for vaccine assessment The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candi... | 05/04/2010 |
| 7682825 | Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to ne... | 03/23/2010 |
| 7666673 | Method of growing sperm stem cells in vitro, sperm stem cells grown by the method, and medium additive kit to be used in growing sperm stem cells in vitro The present invention provides a method of growing spermatogonial stem cells of mammals and the like in vitro, which is characterized in that glial cell-derived neurotrophic factor (GDNF) or an equivalent thereto, and leukemia inhibitory factor (LIF) are contained i... | 02/23/2010 |
| 7598082 | Process of mammalian cell reprogramming through production of a heterokaryon This invention relates to the reprogramming of animal cells and animal cell nuclei by nuclear addition. The invention also relates to the generation of animal cells, cell lines, tissues, organs, embryos and non-human animals by methods involving nuclear addition. | 10/06/2009 |
| 7592176 | Method of forming mesenchymal stem cells from embryonic stem cells This invention relates to methods of producing a substantially homogenous population of mesenchymal stem cells derived from embryonic stem cells. Also, disclosed is a homogenous population of mesenchymal stem cells capable of further differentiating into a variety o... | 09/22/2009 |
| 7592175 | Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and cell cultures prepared using same The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in... | 09/22/2009 |
| 7588936 | Generating teeth from bone marrow cells The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for purification and expansion of a population of cells. ... | 09/15/2009 |
| 7553662 | Culturing tissue using magnetically generated mechanical stresses A method of culturing tissue comprises growing tissue forming cells whilst subjecting the tissue forming cells to mechanical stresses which are generated magnetically. ... | 06/30/2009 |
| 7547545 | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods of producing a neural cell by causing a marrow stromal cell to diffe... | 06/16/2009 |
| 7541183 | Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the inve... | 06/02/2009 |
| 7498168 | Tooth progenitor cell and method for its production The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell. ... | 03/03/2009 |
| 7494811 | In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby The present invention is directed to a method of growing new bone, bone-like tissue or extracellular matrix under in vitro cell culture conditions. The method utilizes a bioreactor allowing for the flow of nutrient solutions into, through, and out of the bioreactor,... | 02/24/2009 |
| 7494810 | Method for accessing microbial diversity A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an environmental sample comprising at least one novel (uncultivated in the ... | 02/24/2009 |
| 7432104 | Methods for the culture of human embryonic stem cells on human feeder cells Methods and cell culture medium for the generation of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human granulosa feeder cells, muscle cells, Fallopian ductal epithelial cells, bone marrow stromal cells, and ski... | 10/07/2008 |
| 7429490 | Tissue engineered uterus The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue ... | 09/30/2008 |
| 7410798 | Culture system for rapid expansion of human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described ... | 08/12/2008 |
| 7402432 | Process for producing T lymphocytes The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts. ... | 07/22/2008 |
| 7402430 | MHC class II antigen-presenting systems and methods for activating CD4T cells The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matric... | 07/22/2008 |
| 7399632 | Mesenchymal precursor cell A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differen... | 07/15/2008 |
| 7396681 | Application of Hsp70 proteins The invention relates to the use of Hsp70 protein or fragments thereof for the activation of NK-cells, pharmaceutical preparations, medical product or medical adjuvants containing a Hsp70 protein or fragments thereof or activated cells, method for the activation of ... | 07/08/2008 |
| 7393687 | Biomimetic 3-dimensional scaffold with metabolic stream separation for bioartificial liver device A bio-artificial organ comprises a substrate comprising a roll of a substrate material, and a plurality of cells adhered to the substrate, the roll being formed from a sheet rolled to form a plurality of layers that include spacers and spaced openings such that at l... | 07/01/2008 |
| 7393685 | Method for cultivating cancer cells from human tissue and device for preparing tissue samples The invention relates to a method for cultivating cancer cells for scientific serial assays, wherein a tissue sample which is heterogeneous with respect to contaminants, normal cells and tumor cells is locally separated in a sequential-parallel splitting method. The... | 07/01/2008 |
| 7371576 | CD56 positive human adult pancreatic endocrine progenitor cells The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into insulin producing cells or into insulin producing cell aggregates. ... | 05/13/2008 |
| 7361506 | Differentiation of specialized dermal and epidermal cells into neuronal cells Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting of keritinocytes and/or melanocytes; taking a sample of tissue from th... | 04/22/2008 |
| 7344712 | Urinary tract tissue graft compositions and methods for producing same A method for providing a urinary tract tissue graft composition includes providing a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in a tissue culture frame such that the segment of small intestinal submucosa is susp... | 03/18/2008 |
