Quotables
"What can be more palpably absurd than the prospect held out of locomotives traveling twice as fast as stagecoaches?"
The Quarterly Review ; March edition, 1825
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8187877 | Chronic lymphocytic leukemia cell line The preparation and characterization of antibodies that bind to antigens on CLL or other cancer cells, especially to antigens upregulated in the cancer cells, and the identification and characterization of antigens present on or upregulated by cancer cells are usefu... | 05/29/2012 |
| 8187876 | Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof. ... | 05/29/2012 |
| 8183040 | Methods for in vitro differentiation of Th-17+cells The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). The instant method may be used to generate a population of human T helper lymphocytes tha... | 05/22/2012 |
| 8153425 | Dendritic cell compositions and methods Methods are provided for the production of dendritic cells from monocytes that have been incubated at a temperature of 1° C.-34° C. for a period of approximately 6 to 96 hours from the time they are isolated from a subject. After the incubation period, the monocyt... | 04/10/2012 |
| 8133726 | Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 03/13/2012 |
| 8119401 | IL-10 gene transfer to peripheral mononuclear cells The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence encoding a polypeptide having IL-10 activity into peripheral blood mononu... | 02/21/2012 |
| 8084255 | Stem cells treated by in vitro fucosylation and methods of use A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an α1,3-fucosyltransferase, e.g., α1,3-fucosyltransferase VI, is used in vitro... | 12/27/2011 |
| 8084256 | Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 12/27/2011 |
| 8053234 | Induction of dendritic cell development with macrophage-colony stimulating factor (M-CSF) A method of inducing dendritic cell (DC) development by administering Macrophage-Colony Stimulating Factor is provided. M-CSF induces DCs to differentiate into subtypes, for example plasmacytoid DCs and conventional DCs. Induction with M-CSF can be achieved in vitro... | 11/08/2011 |
| 8017392 | Hox11+, CD45− cells and methods of organ regeneration using the same The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of the pancreas, liver cells, spleen cells, or bone cells, that has inju... | 09/13/2011 |
| 7989203 | Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cy... | 08/02/2011 |
| 7981673 | Process for the maturation of dendritic cells and a vaccine The invention proves a method of producing mature dendritic cells in vitro, which comprises the step of culturing the immature dendritic cells in the presence of a specifically configured high molecular weight double stranded RNA (dsRNA) polymer. The specifically co... | 07/19/2011 |
| 7977094 | Compositions for repair of defects in osseous tissues, and methods of making the same Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a past... | 07/12/2011 |
| 7972847 | Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use The present invention discloses novel dendritic cell maturation-inducing cytokine cocktails, and methods for inducting type-1 polarized dendritic cells in serum-free conditions which enhance the desirable properties of DC1s generated in serum-supplemented cultures. ... | 07/05/2011 |
| 7960175 | Process for producing human-origin immunocompetent cell It is an object of the present invention to provide an immunodeficient animal capable of generating human-derived lymphoid cells, a human-derived lymphoid cell, and a method for producing a human antigen-specific antibody. The means for solving the aforementi... | 06/14/2011 |
| 7919316 | Hematopoietic stem cell identification and isolation The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− | 04/05/2011 |
| 7919315 | In vitro method for the diagnosis of cardiovascular functionality of bone marrow precursor cells (BMPS) and/or blood-derived circulating precursor cells (BDPS) The present invention relates to an in vitro method for the analysis of a sample from a mammal in connection with cardiovascular diseases, wherein the method comprises the following steps: a) isolating of bone marrow-precursor cells (BMPs) and/or blood-derived circu... | 04/05/2011 |
| 7915043 | CD34(+) cells and their methods of use The present invention provides isolated cells that are selectively enriched for hematopoietic progenitor cells that are precursors for natural killer (NK) cells. These cells are both CD34 and CD45RA positive and express C-integrin β7, and are referred to... | 03/29/2011 |
| 7906331 | Methods for identifying stem cells expressing breast cancer resistance protein (BCRP) The present invention includes methods of identifying and/or isolating stem cells based on expression of BCRP. The present invention also describes methods of obtaining and/or using cell populations enriched for stem cells. In addition, methods are provided for diag... | 03/15/2011 |
| 7863043 | Stem cell populations and methods of use Populations of stem cells and methods for their isolation and use are provided. These stem cell populations comprise aldehyde dehydrogenase positive (ALDHbr) cells isolated from bone marrow, and ALDHbr CD105+ cells derived from any s... | 01/04/2011 |
| 7855074 | Artificial immune system: methods for making and use The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial... | 12/21/2010 |
| 7855075 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 12/21/2010 |
| 7842501 | Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 11/30/2010 |
| 7838289 | Assay utilizing multipotent adult stem cells The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are... | 11/23/2010 |
| 7838290 | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least ... | 11/23/2010 |
| 7833789 | Monocyte cell The present invention relates to human and mouse monocyte cells expressing Tie2 and CD14 or CD16 and their use in methods for regulating angiogenesis and vascular integrity, such as methods of inducing angiogenesis, promoting vessel growth or stabilization, treating... | 11/16/2010 |
| 7816135 | Method of analyzing lymphocytes The invention provides methods and compositions for identifying and counting lymphocytes in a biological sample, such as whole blood, by means of a probe comprising at least one binding compound specific for a T lymphocyte-specific marker, e.g. a CD2 or CD3, and at ... | 10/19/2010 |
| 7816134 | Method of extensive culture of antigen-specific cytotoxic T cells The present invention provides methods for inducing, maintaining and expanding CTL (cytotoxic T cell) having an antigen-specific cytotoxic activity at a high level, which is useful in the adoptive immunotherapy, by using as an effective ingredient at least one compo... | 10/19/2010 |
| 7790453 | Smooth muscle progenitor cells Purified populations of smooth muscle progenitor cells are provided as well as methods of making and using the cells. ... | 09/07/2010 |
| 7785883 | Automatable artificial immune system (AIS) The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial... | 08/31/2010 |
| 7781213 | Method for producing dendritic cells Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of pro... | 08/24/2010 |
| 7776594 | Bone marrow infusion chamber and method A method and apparatus for preparing a bone graft composite using an infusion chamber. A modular tube having a porous material contained therein and having removable end caps is provided. Bone marrow aspirate or other bone morphogenic protein containing suspensions ... | 08/17/2010 |
| 7776595 | Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoieti... | 08/17/2010 |
| 7771999 | Disease model incorporation into an artificial immune system (AIS) The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system... | 08/10/2010 |
| 7771998 | Pharmaceutical composition for inducing an immune response in a human or animal The present invention relates to a pharmaceutical composition for inducing an immune response in a human or animal, comprising dendritic cells loaded with at least five cancer/testis antigen and no lineage specific differentiation antigens or substantially no lineag... | 08/10/2010 |
| 7754480 | Method of isolating stem cells The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to stem cell populations isolatable in accordance with the present metho... | 07/13/2010 |
| 7709256 | Disease model incorporation into an artificial immune system (AIS) The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endoth... | 05/04/2010 |
| 7687264 | Methods and agents of decalcifying bone Decalcification can be performed by using acid or other agents. It may be difficult to decalcify large bone block within ours. This invention provides a bone-decalcifying agent including a calcium desolving agent for desolving calcium ions of bones, and a bubble-for... | 03/30/2010 |
| 7560280 | Human cord blood derived unrestricted somatic stem cells (USSC) A composition in human cord and placental blood which comprises unrestricted somatic stem cells is described here which can be amplified in vitro to large quantities sufficient for medical applications as regenerative medicines. Initiation and maintenance as well as... | 07/14/2009 |
| 7541182 | In vitro test to detect risk of preeclampsia The present invention provides methods for identifying patients at risk of developing preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients with preeclampsia. ... | 06/02/2009 |
