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| Number | Title | Issue Date |
| 8124409 | Utilizing liver cell line QSG-7701 to be infected with hepatitis B virus The use of the liver cell line QSG-7701 for HBV infection includes the following steps: directly infecting QSG-7701 cells with purified HBV particles and facilitating the infection by DMSO and/or PEG treatment. The easily available QSG-7701 liver cell line may not r... | 02/28/2012 |
| 8017391 | Human liver cancer cell line The present invention relates to a human hepatoma-derived cell line, LH86, liver cell cultures, non-human animal models, artificial livers, liver assist devices, screening assays, and other applications of the cell line as an investigational tool. ... | 09/13/2011 |
| 7879606 | Compositions and methods useful for HCV infection The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present i... | 02/01/2011 |
| 7871980 | Method of treating mouse carrying human hepatocytes Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, hum... | 01/18/2011 |
| 7811818 | Human liver engrafting cells isolated from adult liver tissue A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues.... | 10/12/2010 |
| 7776593 | Hes6 as a marker of pancreatic endocrine cells The present invention provides methods of identifying endocrine stem and progenitor cells. ... | 08/17/2010 |
| 7645610 | Hepatocyte precursor cell lines The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permi... | 01/12/2010 |
| 7566567 | Immortalized hepatocytes This invention relates to virally-immortalized hepatocyte cell lines, which are derived from a normal primary human liver cell, have the ability to proliferate in a serum-free media, are nontumorigenic, and produce proteins. These cell lines can be used for toxicity... | 07/28/2009 |
| 7560279 | Method of proliferating human hepatocytes and method for obtaining human hepatocytes Transplanting human hepatocytes into a liver of an immunodeficient hepatopathy mouse, and then feeding the mouse transplanted with the human hepatocytes under such a condition as being protected from the attack by human complement produced by the human hepatocytes t... | 07/14/2009 |
| 7521234 | Mammalian immortalized liver cell The present invention provides a mammalian immortalized liver cell obtained by transferring a cell proliferation factor gene located between a pair of site-specific recombination sequences into a mammalian liver cell. ... | 04/21/2009 |
| 7456018 | Human hepatoma lines, methods for obtaining same and uses thereof Human hepatoma cell lines are provided that comprises a set of cells clonally derived from a cancerous human liver cell, in which each cell of the set expresses a receptor having an affinity for binding a virus of the Flaviviridae genus and a virus of the ... | 11/25/2008 |
| 7456017 | Processes for clonal growth of hepatic progenitor cells A method of propagating mammalian endodermally derived progenitors such as hepatic progenitors, their progeny, or mixtures thereof is developed which includes culturing mammalian progenitors, their progeny, or mixtures thereof on a layer of embryonic mammalian feede... | 11/25/2008 |
| 7429376 | Methods of screening for compounds that improve engraftment The invention provides for methods of screening for compounds that increase the expression of P-selectin, SDF-1, and/or CXCR4 on facilitatory cells (FCs). The invention also provides for methods of screening for compounds that increase the level of p-predendritic ce... | 09/30/2008 |
| 7390651 | C3A serum-free clonal cell line and methods of use A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the cells of the serum-free C3A c... | 06/24/2008 |
| 7371384 | Compositions and methods of using angiopoietin-like 4 protein antibody ANGPTL4 compositions and methods of using such compositions, and agonists or antagonists thereof, for the diagnosis and treatment of diseases or disorders are included, including methods to modulate cell proliferation, cell adhesion, and cell migration. ... | 05/13/2008 |
| 7371576 | CD56 positive human adult pancreatic endocrine progenitor cells The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into insulin producing cells or into insulin producing cell aggregates. ... | 05/13/2008 |
| 7351584 | Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-... | 04/01/2008 |
| 7344723 | Self-replicating RNA molecule from hepatitis C virus A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV... | 03/18/2008 |
| 7332589 | Variants of alpha-fetoprotein coding and expression sequences The invention discloses the sequences of variant forms of alpha-fetoprotein transcripts that have been identified in human hemopoietic progenitors but not in differentiated mature cells. The variant forms of AFP (vAFP) cDNA sequences isolated from a multipotent hemo... | 02/19/2008 |
| 7332336 | Methods for inducing differentiation of pluripotent cells The present invention provides methods for inducing the differentiation of pluripotent cells. The present inventors succeeded in differentiating hepatocytes from ES cells without EB formation, using simple adherent monoculturing in media comprising several growth fa... | 02/19/2008 |
| 7329741 | Polynucleotides that hybridize to DP-75 and their use The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, r... | 02/12/2008 |
| 7326572 | Endoderm cells from human embryonic stem cells This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High qual... | 02/05/2008 |
| 7285383 | Method for selective inactivation of viral replication Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determini... | 10/23/2007 |
| 7282366 | Hepatocytes for therapy and drug screening made from embryonic stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 10/16/2007 |
| 7282352 | Homogeneity and secretion of recombinant proteins in mammalian systems The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human ... | 10/16/2007 |
| 7262051 | Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity... | 08/28/2007 |
| 7256042 | Process for making hepatocytes from pluripotent stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 08/14/2007 |
| 7253150 | Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin The invention relates to gene delivery vehicles which comprise nucleic acid molecules encoding apoptosis-inducing proteins VP2 and/or apoptin (VP3) like activity. VP2 and VP3 are viral proteins of the Chicken Anaemia Virus. Also, the invention relates to anti-tumor ... | 08/07/2007 |
| 7250294 | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells This invention provides populations of neural progenitor cells and differentiated neurons, obtained by culturing pluripotent cells in special growth cocktails. The technology can be used to produce progenitors that proliferate through at least ˜40 doublings, while ... | 07/31/2007 |
| 7235353 | Predicting hepatotoxicity using cell based assays Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of p... | 06/26/2007 |
| 7211404 | Liver engrafting cells, assays, and uses thereof A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues.... | 05/01/2007 |
| 7201911 | Cloned genomes of infectious hepatitis C viruses and uses thereof The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the developme... | 04/10/2007 |
| 7186553 | Human derived immortalized liver cell line The present invention relates to a new immortalized hepatocyte culture of human (preferably human fetal) normal cell origin. The immortalized hepatocyte culture of human normal cell origin of the present invention is useful in, for example, screening for compounds o... | 03/06/2007 |
| 7160719 | Bioartificial liver system A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes... | 01/09/2007 |
| 7157275 | Peptides for enhanced cell attachment and growth The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, whe... | 01/02/2007 |
| 7094559 | Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds ... | 08/22/2006 |
| 7045284 | Method for selective inactivation of viral replication Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determini... | 05/16/2006 |
| 7041501 | Methods of screening for toxicity of test compounds The present invention relates to methods of screening drug candidates for toxic effects on human cells. The invention provides methods for determining idiosyncratic toxicity of test compounds. ... | 05/09/2006 |
| 7033744 | Method for proliferating a liver cell, a liver cell obtained thereby, and use thereof The present invention provides a method comprising a step of transferring a cell proliferation factor gene into a mammalian liver cell to obtain an immortalized liver cell, a step of proliferating the immortalized liver cell, and a step of removing the cell prolifer... | 04/25/2006 |
| 7029915 | Method for differentiating rat hepatic stem cells to insulin-producing cells Highly purified hepatic stem cells are trans-differentiated into pancreatic endocrine hormone-producing cells by culturing them in vitro in a medium containing high levels of glucose. These trans-differentiated cells express insulin, glucagon, and pancreatic polypep... | 04/18/2006 |
