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| Number | Title | Issue Date |
| 7662627 | Adeno-associated virus materials and methods The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines produci... | 02/16/2010 |
| 7416840 | Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection. ... | 08/26/2008 |
| 7368285 | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including mo... | 05/06/2008 |
| 7358086 | Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products This invention utilizes a two-hybrid system to screen for agents that modulate the ability of a cell to degrade or to accumulate a metabolic product or to selective kill a cell or to selectively express a gene or cDNA in a cell that has a defect in its ability to de... | 04/15/2008 |
| 7329741 | Polynucleotides that hybridize to DP-75 and their use The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, r... | 02/12/2008 |
| 7273727 | Fusion proteins for prodrug activation The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is ... | 09/25/2007 |
| 7235401 | Method for determining cell cycle position The invention provides a novel, non-destructive and dynamic process for determining the cell cycle position of living cells. The invention also provides DNA constructs, and cell lines containing such constructs, that exhibit activation and deactivation of a detectab... | 06/26/2007 |
| 7214514 | Identification of human cell lines for the production of human proteins by endogenous gene activation A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a pro... | 05/08/2007 |
| 7208273 | Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing drug-induced torsade de pointes or ventricular fibrillation when admin... | 04/24/2007 |
| 7172893 | Virus vectors and methods of making and administering the same The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabili... | 02/06/2007 |
| 7157244 | Adenosine receptor The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. Th... | 01/02/2007 |
| 7070998 | Adeno-associated virus materials and methods The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines produci... | 07/04/2006 |
| 7063964 | Nucleic acids encoding IL-12 antibody The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, metho... | 06/20/2006 |
| 7052857 | Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify GPCR modulators The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention further relates to the use of human CNG channels to profile, screen for, an... | 05/30/2006 |
| 7018838 | Substrates, devices, and methods for cellular assays The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitatin... | 03/28/2006 |
| 6994975 | Expression and purification of ATM protein using vaccinia virus The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein. In particular, a method is disclosed for using a vaccinia virus vec... | 02/07/2006 |
| 6972194 | Use of polyacrylamide gel for forming a connective-tissue capsule in a mammal for cultivating allogenic and xenogenic cells The invention relates to the field of medicine and more particularly it relates to the problem of vaccination against tumor cells and vaccinotherapy of oncological diseases, and also to a method of treating diabetes mellitus. In the invention a new method of cultiva... | 12/06/2005 |
| 6960616 | Expanded porous thermoplastic polymer membranes Open-celled membranes from thermoplastic polymers are prepared from foamed polymer melts by extrusion through a die and particulary suitable for filtration. ... | 11/01/2005 |
| 6943245 | Tumor suppressor CAR-1 The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney and breast cancers, and the CAR-1 ubiquitous expression of the correspo... | 09/13/2005 |
| 6924128 | Packaging cell lines for generation of high titers of recombinant AAV vectors AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be clinically useful for human gene therapy application. Stable AAV packagi... | 08/02/2005 |
| 6924142 | Hypoxia-mediated neurogenesis assay Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be... | 08/02/2005 |
| 6897063 | Accessory functions for use in recombinant AAV virion production Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producin... | 05/24/2005 |
| 6852531 | Compositions and methods for reproducing and modulating mammalian messenger RNA decapping An in-vitro system in which mammalian messenger RNA decapping occurs is provided, for use in identifying modulators, deficiencies, and other aspects of the regulation of RNA turnover. ... | 02/08/2005 |
| 6846673 | Identification of human cell lines for the production of human proteins by endogenous gene activation A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a pro... | 01/25/2005 |
| 6835565 | Alzheimer's disease secretase The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. ... | 12/28/2004 |
| 6803231 | Method of delivering antigens for vaccination with a live vector The present invention provides a mutant C. fetus strain in which one or more sapA homologs are altered by an inserted DNA cassette so that the encoded S-layer proteins represent a chimera between the native S-layer proteins and a heterologous peptide encoded ... | 10/12/2004 |
| 6797462 | Cell-based assay for immunodeficiency virus infectivity and sensitivity Methods and reagents for the capture of primary HIV are provided. A cell line expressing CCR5, CXCR4 and CD4 receptors binds and is infected by primary HIV. The cell line contains a marker gene sequence, the marker gene sequence expressed in near linear quantities o... | 09/28/2004 |
| 6790612 | Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease A cell-based assay system in which the detection of the reporter gene activity, or secreted alkaline phosphatase (SEAP), is dependent upon the protease activity of the Hepatitis C virus NS3 gene product. This system can be used to assess the activity of candidate pr... | 09/14/2004 |
| 6764674 | Adenovirus E1B shuttle vectors Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, and optionally the substitution therefore of a heterologous gene that substantially exhibits the temp... | 07/20/2004 |
| 6759237 | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same An improved tet-repressible system is described in which the transgene is expressed under the control of a promoter which is activated upon binding of a fusion protein composed of a reverse tet repressor/activation domain to tet operator sequences located immediatel... | 07/06/2004 |
| 6734005 | Matrix metalloproteinases The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using al... | 05/11/2004 |
| 6706495 | Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are also provided that include a polynucleotide encoding a Staphylococcal ... | 03/16/2004 |
| 6677156 | Non-adenoviral gene product-based complementing cells for adenoviral vectors The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene... | 01/13/2004 |
| 6670139 | Cell-free assay using oncogene-induced apoptosis to identify inhibitors of apoptosis in drug-resistant cells The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound which selectively activates apoptosis in transformed cells. ... | 12/30/2003 |
| 6627398 | System for reproducing and modulating stability and turnover of RNA molecules An in vitro system is provided that recapitulates regulated mRNA stability and turnover of exogenous RNA substrates. The system comprises a cell extract optionally depleted of activity of proteins that bind polyadenylate, and a target RNA sequence. This s... | 09/30/2003 |
| 6613569 | Inducible packaging cell lines for lentivirus vectors Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of unregulated expression of certain envelope proteins and lenti... | 09/02/2003 |
| 6596512 | Nucleic acid encoding Nematode dopamine transporter and the protein encoded thereby A nematode dopamine tansporter cDNA has been cloned, sequenced, and expressed, and provides a convenient screening assay for antiparasitics, as well as psychoactive drugs.... | 07/22/2003 |
| 6548296 | Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the... | 04/15/2003 |
| 6541223 | Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is a... | 04/01/2003 |
| 6518021 | Method for extracting quantitative information relating to an influence on a cellular response Cells are genetically modified to express a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Flourescent Protein (GFP, EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent prot... | 02/11/2003 |
