Quotables
"The Americans have need of the telephone, but we do not. We have plenty of messenger boys."
Sir William Preece, chief engineer, British Post Office ; 1878
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7432246 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 10/07/2008 |
| 7368285 | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including mo... | 05/06/2008 |
| 7348401 | Peptides that inhibit complement activation The present invention relates to compositions, including pharmaceutical compositions that inhibit complement activation, and contain amino acid sequences X1-X2-X3-W-E-X4-X5-X6 and/or Z1-C | 03/25/2008 |
| 7329741 | Polynucleotides that hybridize to DP-75 and their use The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, r... | 02/12/2008 |
| 7314710 | Method for replicating the hepatitis C virus The invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for replicating and, if required, the production of HCV or derivative viable mu... | 01/01/2008 |
| 7267965 | Means and methods for regulating gene expression The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the pr... | 09/11/2007 |
| 7175997 | BMP-11 compositions Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the pro... | 02/13/2007 |
| 7160722 | Master bone formation transcription factor: compositions and methods of use A novel gene expressed selectively by osteoblast lines is provided. Expression of the gene is highly restricted to cells of osteoblast lineage, including precursor cells. Also provided is a method for promoting bone formation by providing agents that bind to the nov... | 01/09/2007 |
| 7045335 | Alphavirus replicon vector systems The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent alphavirus particles, as determined by passage on cells in culture. T... | 05/16/2006 |
| 6987091 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 01/17/2006 |
| 6923970 | Retrovirus-like particles made non-infectious by a plurality of mutations Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product, eliminate integrase activity of the pol gene product and eliminate RNase H ac... | 08/02/2005 |
| 6855535 | Method of large scale production of Hepatitis A virus The present invention provides methods of large scale production of Hepatitis A Virus (HAV) on VERO cells bound to microcarrier. The invention also provides for methods of isolation of HAV from the cell culture supernatant of HAV infected VERO cells. ... | 02/15/2005 |
| 6849437 | 47153, a human glycosyltransferase family member and uses therefor The invention provides isolated nucleic acids molecules, designated 47153 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47153 nuc... | 02/01/2005 |
| 6841373 | Herpes virus complementing cell line The present invention is directed to a cell line capable of supporting replication of a growth-defective Herpes Simplex Virus strain; specifically a replication-defective HSV-2 double mutant. Particularly disclosed is a cell line that expresses the ICP8 protein and ... | 01/11/2005 |
| 6825027 | Method of production of purified hepatitis a virus particles and vaccine preparation The present invention provides methods of purification of Hepatitis A Virus from the supernatant of an infected cell culture and production of a preparation of purified HAV antigen. The present invention is also directed to an HAV vaccine composition comprising a pr... | 11/30/2004 |
| 6790612 | Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease A cell-based assay system in which the detection of the reporter gene activity, or secreted alkaline phosphatase (SEAP), is dependent upon the protease activity of the Hepatitis C virus NS3 gene product. This system can be used to assess the activity of candidate pr... | 09/14/2004 |
| 6734005 | Matrix metalloproteinases The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using al... | 05/11/2004 |
| 6680060 | Hepatitus A virus vaccines A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine ... | 01/20/2004 |
| 6613557 | Papillomavirus HPV16 L1 polynucleotide A method of providing papillomavirus like articles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recom... | 09/02/2003 |
| 6485919 | Human metabotropic glutamate receptors, nucleic acids encoding same and uses thereof In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and ... | 11/26/2002 |
| 6455290 | Tankyrase homolog protein (THP), nucleic acids, and methods related to the same The present invention provides a human polypeptide homolog of human tankyrase protein (THP) and polynucleotides which identify and encode THP. In addition, the invention provides expression vectors, host cells and methods for its production. The invention... | 09/24/2002 |
| 6392028 | Functional DNA clone for hepatitis C virus (HCV) and uses thereof The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in therapeutic, vaccines, and diagnostic applications. The invention... | 05/21/2002 |
| 6338964 | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration A cell culture medium which is low in dissolved carbon dioxide is disclosed. The medium contains less than about 1 g/L added sodium bicarbonate and includes an organic buffer and a metal complexing agent. The medium is preferably essentially free of added... | 01/15/2002 |
| 6303371 | Method of purified rAAV vector production in non-human cell line transfected with cocksackie and adenovirus receptor The invention is directed to novel systems for the high level production of purified recombinant adeno-associated virus (rAAV) vector stocks comprising producer cell lines and helper adenoviruses. These systems provide high level production of rAAV vector... | 10/16/2001 |
| 6284485 | Nucleic acids encoding osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteo... | 09/04/2001 |
| 6258943 | Human neurokinin-3 receptor A recombinant human neurokinin-3 receptor (hereinafter identified as human NK3R) is disclosed which has been prepared by polymerase chain reaction techniques. Also disclosed is the complete sequence of human NK3R complementary DNA; expression systems, inc... | 07/10/2001 |
| 6197541 | Recombinant thrombin receptors and assays using them The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the ... | 03/06/2001 |
| 6187550 | Methods and cell lines for screening compositions and genes for ability to interact with IL-1ଲ and ice processing Embodiments of the present invention are directed to non-naturally occurring cells and methods for screening compositions and genes which interact with interleukin 1 beta and interleukin-1 beta converting enzyme (ICE) processing, methods and non-naturally... | 02/13/2001 |
| 6174701 | Neuronal factor A novel polypeptide, designated neuronal factor (NF), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NF useful in diagnostics and in the recombinant preparation of NF. NF is used in the treatment of... | 01/16/2001 |
| 6156538 | Heterologous gene expression with poliovirus replicon The replication machinery of polio virus is used to express heterologous gene products, such as chloramphenicol acetyl transferase, in mammalian cells. Detectable expression following DNA transfection demonstrated that a polio replicon containing a foreig... | 12/05/2000 |
| 6146873 | Production of orthomyxoviruses in monkey kidney cells using protein-free media Viruses from the family Orthomyxoviridae, particularly influenza virus, can grown in monkey kidney cells, particularly Vero Cells, after passaging the cells in a serum-free or protein-free medium. The use of a proteolytic enzyme, especially trypsin, also ... | 11/14/2000 |
| 6110724 | Rotavirus antigen, vaccine and diagnostic agent for rotavirus infections, and a method for producing the antigen The present invention provides a method for producing a rotavirus antigen which the mass culture is difficult, comprising cloning a cell highly permitting the proliferation of rotavirus from a cell culture; preparing a cloned cell adapted-rotavirus strai... | 08/29/2000 |
| 6090623 | Recombinant human calcium channel ଲ4 subunits Isolated DNA encoding each of human calcium channel 댑 -, 댒 -, ଲ- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the... | 07/18/2000 |
| 6060270 | Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on culturing adult kidney cells in a culture media treated with comb... | 05/09/2000 |
| 6017761 | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant This invention provides a method for obtaining a recombinant retroviral packaging cell capable of producing retroviral vectors as well as the recombinant packaging cell obtained by the method. Also provided is a method of producing recombinant retroviral ... | 01/25/2000 |
| 5981277 | Polypeptides and peptides, nucleic acids coding for them, and their use in the field of tumor therapy, inflammation or immunology An isolated and purified nucleic acid comprising: a nucleotide sequence which has at least 50% sequence identity, with any of the nucleotide sequences coding for polypeptides containing in their pepridic chains: the amino acid sequence of 311 amino acids of FI... | 11/09/1999 |
| 5981214 | Production of proteins using homologous recombination Methods and compositions are provided for expression of mammalian genes in culture. An amplifiable gene is introduced by homologous recombination in juxtaposition to a target gene, the resulting combination of amplifiable gene and target gene transferred ... | 11/09/1999 |
| 5935810 | Mammalian ob polypeptides capable of modulating body weight, corresponding nucleic acids, and diagnostic and therapeutic uses thereof The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulator... | 08/10/1999 |
| 5882926 | Excitatory amino acid transporter gene and uses This invention relates to novel mammalian excitatory amino acid transporter proteins and genes encoding such proteins. The invention is directed towards the isolation, characterization and use of human excitatory amino acid transporter proteins for pharma... | 03/16/1999 |
| 5874251 | DNA encoding the Taenia crassiceps ten kilodalton antigen Antigens derived from Taenia crassiceps have been isolated which have specificity and sensitivity in their reactivity with antibodies against Taenia saginata and Taenia solium. These antigens may therefor be used in diagnostic testing for the serological ... | 02/23/1999 |
