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| Number | Title | Issue Date |
| 7431932 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 10/07/2008 |
| 7422736 | Somatic pluripotent cells The present invention discloses a cultured somatic animal cell having a normal karyotype; the cell develops into an embryoid body when induced in vitro, or develops into a teratoma when introduced into a SCID mouse. Also disclosed is a method of producing such a cel... | 09/09/2008 |
| 7419825 | Isolation of neural stem cells using gangliosides and other surface markers During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem c... | 09/02/2008 |
| 7368285 | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including mo... | 05/06/2008 |
| 7361348 | Immunogenic glycopeptides, screening, preparation and uses The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or fungi), and methods for selecting them and preparing them. Said glycopep... | 04/22/2008 |
| 7294508 | Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the blastocyst stage embryo by laser ablation, and removing the inner cell m... | 11/13/2007 |
| 7282366 | Hepatocytes for therapy and drug screening made from embryonic stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 10/16/2007 |
| 7279305 | Gene, disrupted in schizophrenia A newly identified gene, DIS1 is disrupted by a (1;11)(q42.1;q14.3) translocation which segregates with schizophrenia. We have examined the genomic structure of DIS1 and found that the gene consists of 13 exons estimated to extend across at least 300 kb of DNA. Exon... | 10/09/2007 |
| 7279330 | Method for identifying modulating compounds of neurotransmitters A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a nerve tissue preparation and the possible modulating effect of the compo... | 10/09/2007 |
| 7270998 | Method of concentrating and separating dopaminergic neurons The invention of this application provides a method comprising introducing a reporter nucleic acid molecule that expresses a fluorescent protein under control of the promoter/enhancer of a gene that is expressed in dopaminergic neurons, into each of cells, and isola... | 09/18/2007 |
| 7267965 | Means and methods for regulating gene expression The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the pr... | 09/11/2007 |
| 7264944 | TNF receptors, TNF binding proteins and DNAs coding for them The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein... | 09/04/2007 |
| 7247479 | Pigment epithelial cell of the eye, its production and use in therapy of an eye or CNS disease The present invention relates to a pigment epithelial cell of the eye containing vector DNA of an adenoviral vector with large DNA capacity, to the improved isolation and cultivation of these cells and to methods for production and the use in the therapy of an eye o... | 07/24/2007 |
| 7232685 | Cell lines with latent immunodeficiency virus and methods of use thereof The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency virus-based retroviral vector. Under basal in vitro culture conditions... | 06/19/2007 |
| 7229825 | Double-transfected cell line useful for the identification of transport inhibitors Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates,... | 06/12/2007 |
| 7223599 | Immortalization of human post-mitotic cells The present invention provides an immortalized human cardiomyocyte cell line. The present invention further provides a method for preparing a human immortalized cell line derived from a post-mitotic primary cell culture. ... | 05/29/2007 |
| 7220584 | Method of making embryoid bodies from primate embryonic stem cells Primate embryoid bodies are formed from primate ES cells. The ES cells form clumps. One then removes the clumps, as clumps, and permits incubation under non-adherent conditions. The development of embryoid bodies from primate ES cells is dependent on maintaining the... | 05/22/2007 |
| 7208273 | Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing drug-induced torsade de pointes or ventricular fibrillation when admin... | 04/24/2007 |
| 7186883 | In vitro propagation of embryonic stem cells The present invention relates to the use of leukemia inhibitory factor (LIF) in the isolation and propagation of embryonic stem cells in vitro. ... | 03/06/2007 |
| 7148062 | Method for generating primate trophoblasts The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a single protein trophoblast induction factor causes the cells to trans... | 12/12/2006 |
| 7138275 | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain... | 11/21/2006 |
| 7132286 | Method for neural stem cell differentiation using valproate The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural ... | 11/07/2006 |
| 7132287 | Method for neural stem cell differentiation using 5HT-1A agonists The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neura... | 11/07/2006 |
| 7115361 | Detection of CD8+ T cell responses to A method of detecting an anti-mycobacterial CD8 T cell response comprising contacting a population of CD8 T cells of an individual with one or more peptides selected from the peptides represented by SEQ ID NO: 3, 4, 7, 8, 9, 10, 11 or 12, and, optionally, one or two... | 10/03/2006 |
| 7112437 | Methods of culturing embryonic stem cells and controlled differentiation The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or somatic differentiation. Preferably the cells are capable of somatic di... | 09/26/2006 |
| 7105345 | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors. ... | 09/12/2006 |
| 7083977 | Monkey-origin embryonic stem cells A method for producing a monkey-derived embryonic stem cell comprising the steps of carrying out fertilization by insemination by in vitro fertilization or intracytoplasmic sperm injection using a monkey ovum and monkey sperms, thereby giving a fertilized ovum, allo... | 08/01/2006 |
| 7070996 | Production of cultured human mast cells and basophils for high throughput small molecule drug discovery Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods generate uniform proliferated populations of cells. The proliferated po... | 07/04/2006 |
| 7052857 | Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify GPCR modulators The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention further relates to the use of human CNG channels to profile, screen for, an... | 05/30/2006 |
| 7045353 | Directed differentiation of human embryonic cells Methods are described for mapping a pathway of differentiation of a population of embryonic cells which includes exposing the cells to an exogenous factor and measuring gene expression products that are characteristic of a particular cell type or lineage. Directing ... | 05/16/2006 |
| 7041438 | Use of human embryonic stem cells for drug screening and toxicity testing This disclosure provides an improved system for culturing human pluripotent stem (pPS) cells in the absence of feeder cells. The role of the feeder cells can be replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned m... | 05/09/2006 |
| 7029913 | Primate embryonic stem cells A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodimen... | 04/18/2006 |
| 7001767 | Method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies The invention concerns a method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies, or prion, comprising steps which consist in: providing a culture or a glial cell line and in infecting the culture or line with the agent... | 02/21/2006 |
| 6994858 | Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, there... | 02/07/2006 |
| 6962789 | Method for quantitating a protein by image analysis The present invention provides a method for determining expression levels of one or a multiplicity of target proteins in a tissue or cell sample. ... | 11/08/2005 |
| 6943016 | Human adult astrocytes, their preparation and uses thereof The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders or trauma to the central nervous system. ... | 09/13/2005 |
| 6921665 | Selective antibody targeting of undifferentiated stem cells This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the ... | 07/26/2005 |
| 6921632 | Human embryonic stem cells derived from frozen-thawed embryo The invention covers a method for establishing undifferentiated human embryonic stem cells by thawing cryopreserved human embryos, preferably blastocyst stage embryos, and culturing at least a portion of the embryos on a medium capable of sustaining undifferentiated... | 07/26/2005 |
| 6916649 | UDP-galactose: β-N-acetyl-glucosamine β-1,4-galactosyltransferase, β4Gal-T2 A novel gene defining a novel enzyme in the UDP-D-galactose: b-N-acetyl-glucosamine β-1,4-galactosyltransferase family, termed β4Gal-T2, with unique enzymatic properties is disclosed. The enzymatic activity of β4Gal-T2 is shown to be distinct from that of previou... | 07/12/2005 |
| 6916642 | Vertebrate telomerase genes and proteins and uses thereof Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying inhibitors of telomerase activity and inhibitor compositions are disclo... | 07/12/2005 |
