Class 435/361 - Expressing recombinant receptor

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the Chinese Hamster ovary cell expresses
No. of patents: 127
Last issue date: 08/23/2011

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Number	Title	Issue Date
8003386	Tumor necrosis factor receptors 6α and 6β The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and rec...	08/23/2011
7964399	Cell line comprising vector encoding truncated FLK-1 receptor The present invention relates to the use of ligands for the FLK-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention s based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells...	06/21/2011
7928073	Purified polypeptides having IL-13 receptor activity This invention relates to a purified polypeptide comprising an amino acid sequence chosen from the sequence SEQ ID NO:4 or biologically active amino acid sequences derived from SEQ ID NO:4. ...	04/19/2011
7691628	Use of Rev-erb family of receptors in screening The present invention relates to the use of receptors of the Rev-erb family to screen substances which are useful in the treatment of lipid metabolism dysfunctions associated with apolipoprotein C-III. The invention relates more particularly to screening methods for...	04/06/2010
7435808	Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2 The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, frag...	10/14/2008
7425445	Modulators that promote cell surface expression of odorant receptors The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptor...	09/16/2008
7416848	DNA encoding SNORF25 receptor This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 r...	08/26/2008
7405051	Method of screening antiplatelet agents A screening tool for an antiplatelet agent wherein the tool is a human ADP receptor P2TAC protein, a variation functionally equivalent thereto, or a homologous protein thereof, and a screening tool for an antiplatelet agent wherein the tool is a transform...	07/29/2008
7393655	Methods of identifying melanin concentrating hormone receptor antagonists This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nuc...	07/01/2008
7393945	Estrogen receptor genes and utilization thereof An estrogen receptor gene and utilization of the estrogen gene are described. The estrogen receptor gene has a nucleotide sequence coding for any of the following amino acid sequences: (a) the amino acid sequence of SEQ ID NO: 1, (b) the amino acid sequence of SEQ I...	07/01/2008
7381560	Expression and use of anti-CD20 antibodies Disclosed are immunologically active antibodies directed against the CD20 antigen, as well as host cells comprising nucleic acid sequences encoding the light chains and heavy chains of immunologically active antibodies wherein the cell is capable of expressing and s...	06/03/2008
7368285	Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including mo...	05/06/2008
7306922	Human and rat PGC-3, PPAR-gamma coactivations and splice variants thereof A novel gene PGC-3, and its role in regulating the transcriptional activity of PPARγ in adipose tissue. PGC-3 is highly expressed in human white adipose tissue and has utility in the development of new therapeutic agents for use in the treatment of obesity and othe...	12/11/2007
7285413	Isolation tool for viable c-kit expressing cells A tool for the isolation of c-kit expressing cells is provided. This tool consists of a c-kit plasmid targeting vector which is capable of integrating into the wild type c-kit allele and encodes a chimeric fluorescent protein comprising a nucleolar localization sign...	10/23/2007
7282483	Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein...	10/16/2007
RE39792	Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ...	08/21/2007
7238776	TNF binding proteins The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein...	07/03/2007
7211259	4-1BB polypeptides and DNA encoding 4-1BB polypeptides Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and ...	05/01/2007
7198913	Nucleic acids encoding a tumor necrosis factor homolog The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid s...	04/03/2007
7166445	Methods and host cells for improved cell culture The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics. ...	01/23/2007
7157244	Adenosine receptor The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. Th...	01/02/2007
7112421	Nucleic acids encoding BAFF receptor, chimeric proteins and methods and compositions related thereto Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pha...	09/26/2006
7091004	Regulation of translation for recombinant protein production The invention provides cells that produce increased levels of recombinant protein by modulating the activity of translational regulator gene products that are downstream targets of PKB alpha, methods of making such cells, and methods of using such cells. Such transl...	08/15/2006
7083949	Receptor based antagonists and methods of making and using The present invention provides a fusion polypeptide that forms a multimer that is capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion po...	08/01/2006
7081360	Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties Modified forms of G protein-coupled receptors which display altered ligand binding and/or coupling properties are provided as well as cells expressing such receptors and assays utilizing these cells for screening and identifying pharmaceutically effective compounds ...	07/25/2006
7052843	Transcription-based assay for identification of post-translational modification and its application in proteomics The present invention relates to a method for detecting the post-translational modification of a target protein by a post translational modifier polypeptide molecule; a method for screening a candidate protein for E3 ligase activity; a method of screening a test com...	05/30/2006
7049402	Tumor necrosis factor receptor-5 The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor n...	05/23/2006
7041501	Methods of screening for toxicity of test compounds The present invention relates to methods of screening drug candidates for toxic effects on human cells. The invention provides methods for determining idiosyncratic toxicity of test compounds. ...	05/09/2006
7037665	Compositions comprising SNORF36 receptor compounds This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 r...	05/02/2006
7037710	Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ...	05/02/2006
7029857	Processes for obtaining compounds employing SNORF72 receptors This invention provides isolated nucleic acids encoding mammalian SNORF62 and SNORF72 receptors, purified mammalian SNORF62 and SNORF72 receptors, vectors comprising nucleic acid encoding mammalian SNORF62 and SNORF72 receptors, cells comprising such vectors, antibo...	04/18/2006
7029914	DNA encoding SNORF36 receptors This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 r...	04/18/2006
6984520	Bioassay for thyroid stimulating antibodies An assay method for TSH-R autoantibodies or TSH comprises contacting a test sample, in the presence or absence of TSH, with cells from a clone expressing human TSH-R transfected with a reporter construct comprising cDNA of both (i) a reactant, such as an enzyme, cap...	01/10/2006
6927044	IL-1 receptor based cytokine traps Fusion polypeptides capable of binding interleukin-1 (IL-1) to form a nonfunctional complex are provided and nucleic acid molecules encoding the fusion polypeptides. The fusion ploypeptides form dimers to function as IL-1 antagonists. ...	08/09/2005
6858409	Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors Compounds are disclosed having the general formula R1—X—R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2 ...	02/22/2005
6787642	Use of insect cell membrane transporters as novel target sites for inspection The present invention discloses the existence of novel insect transporters that can be used as targets for screening of new insecticides. This invention provides nucleic acids which encode the following insect cell membrane transporters: acetylcholine transporters, ...	09/07/2004
6770444	Methods of identifying or screening for agents that binds the Ob-Re This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for dete...	08/03/2004
6723552	DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nuc...	04/20/2004
6692938	Nucleic acids encoding active and inactive CCR5 chemokine receptors A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic acid sequences listed as SEQ ID NO:1, SEQ ID NO:2 and SEQ ID ...	02/17/2004
6639123	Melanocortin-3 receptor deficient cells, non-human trangenic animals and methods of selecting compounds which regulate body weight Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased fatmass and reduced lean body mass, showing that the MC-3R pro...	10/28/2003

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Class 435/361 - Expressing recombinant receptor