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| Number | Title | Issue Date |
| 7371377 | Antibodies to polypeptides homologous to VEGF and BMP1 The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF inclu... | 05/13/2008 |
| 7309694 | Modified cytokines for use in cancer therapy Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents. ... | 12/18/2007 |
| 7282352 | Homogeneity and secretion of recombinant proteins in mammalian systems The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human ... | 10/16/2007 |
| RE39792 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 08/21/2007 |
| 7226908 | Use of VEGF and homologues to treat neuron disorders The present invention relates to neurological and physiological dysfunction associated with neuron disorders. In (particular, the invention relates to the involvement of vascular endothelial growth factor (VEGF) and homologues in the aetiology of motor neuron disord... | 06/05/2007 |
| 7202215 | Long-acting follicle stimulating hormone analogues and uses thereof This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject. ... | 04/10/2007 |
| 7166445 | Methods and host cells for improved cell culture The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics. ... | 01/23/2007 |
| 7101706 | Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase The present invention relates to novel polynucleotides encoding polypeptides homologous to heparanase, nucleic acid constructs including these novel polynucleotides, genetically modified cells expressing the same, recombinant proteins encoded thereby and which may h... | 09/05/2006 |
| 7091004 | Regulation of translation for recombinant protein production The invention provides cells that produce increased levels of recombinant protein by modulating the activity of translational regulator gene products that are downstream targets of PKB alpha, methods of making such cells, and methods of using such cells. Such transl... | 08/15/2006 |
| 7083978 | Nucleic acid encoding PRO1111 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 08/01/2006 |
| 7012130 | Methods of purifying recombinant human erythropoietin from cell culture supernatants The present invention relates, in general, to a method of purifying recombinant human erythropoietin (EPO). The present invention also relates to a substantially pure EPO. The method comprises a differential precipitation, an hydrophobic interaction chromatography, ... | 03/14/2006 |
| 7008781 | Method of enhancing the biological activity of ligands Novel fusion polypeptide ligands that bind Eph family receptors or the Tie-2 receptor are identified, and methods for making the fusion polypeptide ligands in biologically active form are described. Nucleic acids encoding these novel fusion polypeptide ligands enabl... | 03/07/2006 |
| 6972322 | Interferon and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 12/06/2005 |
| 6969609 | Recombinant vector expressing multiple costimulatory molecules and uses thereof The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect... | 11/29/2005 |
| 6969517 | Recombinant tumor specific antibody and use thereof The invention provides a family of antibodies that specifically bind the human epithelial cell adhesion molecule. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a ... | 11/29/2005 |
| 6897040 | Methods and host cells for improved cell culture The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics. ... | 05/24/2005 |
| 6797515 | Regulated autocrine growth of mammalian cells Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilize mammalian host cells engineered for autonomous and regulated growth in low cost protein/serum-free culture media. Preferred host cells express insulin or an ... | 09/28/2004 |
| 6780607 | Method for cell-free protein complete post-translational modification The present invention relates to methods of production of the completely post-translationally modified protein by combination of cell-free protein synthesis and cell-free co- and post-translational modification. Previous cell-free protein synthesis system has only b... | 08/24/2004 |
| 6777205 | Host cells expressing recombinant human erythropoietin The gene coding for human erythropoietin (EPO) was obtained from human genomic DNA. Thc gene used does not include sequences from regions at i 5′ of the first translated ATG and ii 3′ of the stop codon of the EPO gene. The gene was cloned into an expression plas... | 08/17/2004 |
| 6710025 | Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin The present invention is directed to therapeutic methods that are based upon an ability to modulate cellular contraction. This is accomplished by administering agents that either inhibit or induce the activity of alpha-smooth muscle actin. ... | 03/23/2004 |
| 6689365 | Single-chain fertility hormones with fsh and LH activity Glycosylated or nonglycosylated proteins of the formula FSHଲ-(linker1)n1 -LHଲ(1-X)-(linker2)n2 - wherein FSHଲ is a vertebrate follicle stimulating hormone ଲ subuni... | 02/10/2004 |
| 6670178 | In Vivo production and delivery of insulinotropin for gene therapy The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes erythropoietin or an insulinotropin (e.g., derivatives of ... | 12/30/2003 |
| 6663894 | Intraocular transplantation of encapsulated cells Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-angiogenic activity. Th... | 12/16/2003 |
| 6656729 | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.... | 12/02/2003 |
| 6500449 | Intraocular transplantation of encapsulated cells Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-angiogenic activity. Th... | 12/31/2002 |
| 6485721 | Biologically active substance-secreting hybrid gel The present invention provides a biologically active substance secreting hybrid gel, which consists essentially of a biopolymeric gel and cells containing an expression vector with a gene encoding the biologically active substance to produce the substance... | 11/26/2002 |
| 6485942 | Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production Described herein are vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminus heparin binding domain. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with nat... | 11/26/2002 |
| 6482405 | In situ injection of antigen-presenting cells with genetically enhanced cytokine expression The use of professional antigen presenting cells genetically modified to enhance expression of an immunostimulatory cytokine is disclosed for the treatment of individuals having tumors or infections. The genetically modified professional antigen presentin... | 11/19/2002 |
| 6458350 | ULBP DNA and polypeptides The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented pepti... | 10/01/2002 |
| 6455283 | Nucleic acids encoding vascular endothelial cell growth factor-E (VEGF-E) The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to... | 09/24/2002 |
| 6455300 | Method and compositions for monitoring DNA binding molecules in living cells The present invention provides a method of screening for a compound that binds to a selected nuclei acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array... | 09/24/2002 |
| 6423693 | Growth hormone releasing hormone expression system and methods of use, including use in animals Vectors which establish controlled expression of recombinant GHRH genes within tissues at certain levels. The vector includes a 5' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3' flanking region including... | 07/23/2002 |
| 6413744 | Methods and host cells for improved cell culture The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.... | 07/02/2002 |
| 6306654 | Follicle stimulating hormone-glycosylation analogs Recombinant materials are provided for the production of the -glycoprotein hormone subunit. These muteins have utility as antagonists and in altering pharmacokinetic activity of these hormones.... | 10/23/2001 |
| 6306398 | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.... | 10/23/2001 |
| 6284491 | Biologically active synthetic thyrotropin and cloned gene for producing same Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.... | 09/04/2001 |
| 6284485 | Nucleic acids encoding osteoprotegerin The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteo... | 09/04/2001 |
| 6248723 | Method for treatment of inflammatory disease The present invention relates to a method to protect a mammal from a disease involving inflammation by treating that mammal with a TGFଲ-regulating agent. The present invention also relates to a method for prescribing treatment for a respiratory dise... | 06/19/2001 |
| 6245550 | Cytokine family member EF-7 EF-7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EF-7 polypeptides and polynucleotides in therapy, and diagnostic assays for such.... | 06/12/2001 |
| 6238914 | Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a non-mammalian virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is ex... | 05/29/2001 |
