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| Number | Title | Issue Date |
| 8153423 | Pluripotent cells from the mammalian late epiblast layer This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal speci... | 04/10/2012 |
| 8030071 | Restoration of cholesterol independence and its use as a selectable marker in NS0 cell culture Gene complementation is used to restore cholesterol independence in NS lineage murine myeloma cells, such as NS0 and NS 1, yielding a selectable system for recombinant production of polynucleotides and polypeptides. ... | 10/04/2011 |
| 7883890 | Transposon transfer factor functioned in mammal Genetically modified mammalian cells comprising a Tol2 transposon transferred into a chromosome can be obtained by co-transfecting mammalian cells with a Tol2 transposase encoded by a Tol2 transposon found in medaka fish, and a Tol2 transposon lacking this transposa... | 02/08/2011 |
| 7442545 | Neural colony forming assay A neural colony forming cell (NCFC) assay is described. The assay allows one to distinguish neural stem cells from neural progenitor cells. In one embodiment, the present invention provides a method for identifying neural stem cells or neural progenitor cells compri... | 10/28/2008 |
| 7439060 | Independent helper virus packaging cell line for propagating viral vectors Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vec... | 10/21/2008 |
| 7435591 | Compositions and methods for increasing animal size growth rate The present invention relates to germ line and somatic cells comprising a mutant p27kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growt... | 10/14/2008 |
| 7425446 | Antibody composition-producing cell The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 09/16/2008 |
| 7419825 | Isolation of neural stem cells using gangliosides and other surface markers During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem c... | 09/02/2008 |
| 7416848 | DNA encoding SNORF25 receptor This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 r... | 08/26/2008 |
| 7416840 | Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection. ... | 08/26/2008 |
| 7413898 | Cells and methods for estimation of effects on neurological dysfunction The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowt... | 08/19/2008 |
| 7413903 | Methods of regulating differentiation in stem cells The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and ligands of class III tyrosine kinase receptors are useful in preventing... | 08/19/2008 |
| 7413900 | Immortalized fibroblasts Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early stage mouse embryo is provided. Methods of preparing an immortalized... | 08/19/2008 |
| 7371569 | Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures Procedures to produce a biologically active human TPO by mammalian cells in in vitro cultures are disclosed. Murine myeloma cells were genetically modified by introducing the gene of human thrombopoietin through a DNA construction which includes an immunoglobulin pr... | 05/13/2008 |
| 7361505 | Multipotent neural stem cell compositions The invention provides in vitro cell culture compositions consisting of neurospheres and culture medium, wherein the neurospheres consist of undifferentiated cells that are nestin+, glial fibrillary acid protein (GFAP)−, neurofilament (NF) | 04/22/2008 |
| 7348156 | 7B2 knockout transgenic animals as models of endocrine disease In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human mammals, and ... | 03/25/2008 |
| 7341871 | Nucleotide sequences for gene regulation and methods of use thereof The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or ... | 03/11/2008 |
| 7323334 | Screening and therapeutic methods relating to neurogenesis The invention provides methods of identifying compounds that modulate neurogenesis. The methods involve providing a compound that modulates prokineticin receptor signaling; contacting a neural stem or progenitor cell with the compound; and determining the ability of... | 01/29/2008 |
| 7321074 | Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased fatmass and reduced lean body mass, showing that the MC-3R protein is inv... | 01/22/2008 |
| 7309605 | Nucleotide sequence encoding the enzyme I-I and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 12/18/2007 |
| 7309811 | Transgenic mice knockouts of BACE-1 The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The tran... | 12/18/2007 |
| 7300763 | Method of testing myelotoxicity with the use of flow cytometer The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing smears. To this end, markers for discriminating and identifying hematop... | 11/27/2007 |
| 7294510 | Process for producing nerve stem cells, motor neurons, and GABAergic neurons from embryonic stem cells The present invention provides a method for producing motor neurons and GABAergic neurons characterized by including suspension-culturing embryonic stem cells in the presence or absence of a protein noggin to form embryoid bodies, selectively amplifying into neural ... | 11/13/2007 |
| 7285398 | Tango 240 nucleic acids and uses thereof The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode se... | 10/23/2007 |
| 7285413 | Isolation tool for viable c-kit expressing cells A tool for the isolation of c-kit expressing cells is provided. This tool consists of a c-kit plasmid targeting vector which is capable of integrating into the wild type c-kit allele and encodes a chimeric fluorescent protein comprising a nucleolar localization sign... | 10/23/2007 |
| 7279330 | Method for identifying modulating compounds of neurotransmitters A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a nerve tissue preparation and the possible modulating effect of the compo... | 10/09/2007 |
| 7271000 | Nucleotide sequence encoding the enzyme I-Scel and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 09/18/2007 |
| 7264923 | Norovirus infected cell cultures and uses therefor A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a defic... | 09/04/2007 |
| 7252829 | HLA binding peptides and their uses The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. ... | 08/07/2007 |
| 7253150 | Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin The invention relates to gene delivery vehicles which comprise nucleic acid molecules encoding apoptosis-inducing proteins VP2 and/or apoptin (VP3) like activity. VP2 and VP3 are viral proteins of the Chicken Anaemia Virus. Also, the invention relates to anti-tumor ... | 08/07/2007 |
| 7247766 | Double transgenic mice overexressing human beta secretase and human APP-London The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method... | 07/24/2007 |
| 7247427 | Leptin assay The invention provides a method for determining the presence of leptin in a sample. ... | 07/24/2007 |
| 7247480 | Method for producing dendritic cells Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of pro... | 07/24/2007 |
| 7238360 | Alteration of cell membrane with B7 Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous DNA. DNA sequences, the... | 07/03/2007 |
| 7232683 | Extracellular matrix signaling molecules Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. The polynucleotide compos... | 06/19/2007 |
| 7223556 | Targeted proteolysis by recruitment to ubiquitin protein ligases The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular prot... | 05/29/2007 |
| 7214536 | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes. ... | 05/08/2007 |
| 7205148 | Genome mutation by intron insertion into an embryonic stem cell genome Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombinat... | 04/17/2007 |
| 7189567 | Method of culturing human chondrocytes This invention provides a method for rapidly culturing a large amount of human chondrocytes to give normal chondrocytes or a mass thereof. The culture method comprises co-culturing human chondrocytes together with perichondral cells in the chondrogenic stage, as fee... | 03/13/2007 |
| 7186812 | Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identif... | 03/06/2007 |
