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| Number | Title | Issue Date |
| 7425446 | Antibody composition-producing cell The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 09/16/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7321074 | Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased fatmass and reduced lean body mass, showing that the MC-3R protein is inv... | 01/22/2008 |
| 7300763 | Method of testing myelotoxicity with the use of flow cytometer The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing smears. To this end, markers for discriminating and identifying hematop... | 11/27/2007 |
| 7279330 | Method for identifying modulating compounds of neurotransmitters A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a nerve tissue preparation and the possible modulating effect of the compo... | 10/09/2007 |
| 7273727 | Fusion proteins for prodrug activation The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is ... | 09/25/2007 |
| 7247424 | Screening method for a substance having hypoglycemic activity by using STAT-induced inhibitor of STAT function-1 The present invention discloses a screening method for a substance, which could be a therapeutic agent for diabetes with insulin resistance through regulating a function of a molecule involved in insulin signaling pathway. More specifically, the present invention di... | 07/24/2007 |
| 7244616 | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced express... | 07/17/2007 |
| 7176288 | Human coagulation factor VII variants The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses an... | 02/13/2007 |
| 7132286 | Method for neural stem cell differentiation using valproate The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural ... | 11/07/2006 |
| 7132287 | Method for neural stem cell differentiation using 5HT-1A agonists The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neura... | 11/07/2006 |
| 7098027 | Method for remyelinating a demyelinized lesion due to injury in the brain or spinal cord Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone marrow cells. ... | 08/29/2006 |
| 7083916 | DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof This invention provides isolated nucleic acid molecules which encode inward rectifier, G-protein activated, mammalian, potassium KGA channel. This invention also provides a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with the... | 08/01/2006 |
| 7060869 | Fluorescent protein sensors for detection of analytes Fluorescent indicators including a binding protein moiety, a donor fluorescent protein moiety, and an acceptor fluorescent protein moiety are described. The binding protein moiety has an analyte-binding region which binds an analyte and causes the indicator to chang... | 06/13/2006 |
| 7045335 | Alphavirus replicon vector systems The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent alphavirus particles, as determined by passage on cells in culture. T... | 05/16/2006 |
| 7033749 | Ribonuclease resistant RNA preparation and utilization The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed. ... | 04/25/2006 |
| 7029915 | Method for differentiating rat hepatic stem cells to insulin-producing cells Highly purified hepatic stem cells are trans-differentiated into pancreatic endocrine hormone-producing cells by culturing them in vitro in a medium containing high levels of glucose. These trans-differentiated cells express insulin, glucagon, and pancreatic polypep... | 04/18/2006 |
| 7026524 | Human coagulation factor VII variants The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses an... | 04/11/2006 |
| 7015035 | RD114-based retroviral packaging cell line and related compositions and methods This invention provides a retroviral packaging cell comprising a suitable mammalian cell having therein (i) a first recombinant nucleic acid comprising MMLV gag and pol genes and a selectable marker, and (ii) a second recombinant nucleic acid comprising RD114 envelo... | 03/21/2006 |
| 7005299 | Expression of heterologous genes according to a targeted expression profile A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene trap protocols to obtain expression of the heterologous gene in the h... | 02/28/2006 |
| 7005411 | Method for modulating nerve cell function The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated inversely with the modulation of the effective amount of the Comm po... | 02/28/2006 |
| 6969608 | Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors Current sources of neural stem and progenitor cells for neural transplantation are essentially inaccessible in living animals. This invention relates to neural precursor cells (stem cells, progenitor cells or a combination of both types of cells) isolated from the o... | 11/29/2005 |
| 6960657 | Human coagulation factor VII polypeptides The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, use... | 11/01/2005 |
| 6960470 | Diagnostic methods for drug screening for Alzheimer's disease Methods of screening candidate drugs for the treatment of Alzheimer's disease are provided. Employing tissue slices of mutant mouse hippocampal cells having an extra copy of a mutant form of the presenilin-1 gene, it is found that these cells have enhanced potentiat... | 11/01/2005 |
| 6953692 | Device and method for seed-train expansion of mammalian cells A device and method for seed-train expansion of a source of mammalian cells and their use in production of proteins expressed by the cells comprising the use of a dedicated inoculation bioreactor for expanding the cells prior to the transfer to a production bioreact... | 10/11/2005 |
| 6943016 | Human adult astrocytes, their preparation and uses thereof The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders or trauma to the central nervous system. ... | 09/13/2005 |
| 6936457 | DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, CELLS TRANSFORMED THEREWITH, AND RECOMBINANT CELL LINE EXPRESSING A HUMAN α AND β SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing α and β subunits and recombinant (i.e., isolated or substan... | 08/30/2005 |
| 6924128 | Packaging cell lines for generation of high titers of recombinant AAV vectors AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be clinically useful for human gene therapy application. Stable AAV packagi... | 08/02/2005 |
| 6908764 | Recombinant human cell for bone and cartilage cell formation The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another member of the T-box family. ... | 06/21/2005 |
| 6905683 | Human coagulation factor VII variants The invention concerns novel coagulation factor VII variants, wherein the Leu residue in position 305 or the Phe residue in position 374 of SEQ ID NO 1 has been replaced by another amino acid residue which can be encoded by nucleic acid constructs and, optionally, w... | 06/14/2005 |
| 6897061 | Transdifferentiation of glial cells A process for generating multipotent cells from glial cells using in vitro techniques to dedifferentiate fetal or adult mammalian glial cells into multipotent cells. The multipotent cells may further be differentiated into particular types of nervous system cells, i... | 05/24/2005 |
| 6890724 | Methods and compositions for neural progenitor cells The invention relates to methods and compositions for the isolation of neural progenitor cells. ... | 05/10/2005 |
| 6872569 | In vitro production of haploid germ cells The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method de... | 03/29/2005 |
| 6852510 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and, more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vectors, ... | 02/08/2005 |
| 6835565 | Alzheimer's disease secretase The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. ... | 12/28/2004 |
| 6825037 | Recombinant transferrins, transferrin half-molecules and mutants thereof Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functional form by stable euk... | 11/30/2004 |
| 6803233 | Model for Alzheimer's disease and other neurodegenerative diseases The present invention provides a model for studying the development of, and/or pathologies associated with neurodegenerative diseases, and agents that can alter such development and/or pathologies. The model of the invention is especially useful as an Alzheimer's di... | 10/12/2004 |
| 6790612 | Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease A cell-based assay system in which the detection of the reporter gene activity, or secreted alkaline phosphatase (SEAP), is dependent upon the protease activity of the Hepatitis C virus NS3 gene product. This system can be used to assess the activity of candidate pr... | 09/14/2004 |
| 6740519 | Immortalized, homozygous stat1-deficient mammalian cell lines and their uses The present invention is directed to immortalized STAT1-deficient mammalian cell lines. STAT1 is a signal transducer and activator of transcription that becomes phosphorylated when cells are treated with type I or type II interferons and leads to induction of specif... | 05/25/2004 |
| 6730821 | Transgenic mice containing retina-specific nuclear receptor gene disruptions The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in genes, which are useful as models for d... | 05/04/2004 |
