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| Number | Title | Issue Date |
| 7964398 | Modified vaccinia ankara virus variant and cultivation method The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 06/21/2011 |
| 7964395 | Modified vaccinia ankara virus variant and cultivation method The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 06/21/2011 |
| 7964396 | Modified vaccinia ankara virus variant and cultivation method The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 06/21/2011 |
| 7964397 | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The method for the cultivation of... | 06/21/2011 |
| 7425614 | Neuroprotective therapeutics preventing ERK/MAPK activation through the NMDA receptor Methods for identifying neuroprotective compounds, as well as compositions and methods for treating subjects suffering from neurological diseases or disorders are provided. ... | 09/16/2008 |
| 7358066 | Variants and exons of the GlyT1 transporter The present invention provides polypeptide and polynucleotide sequences for novel splice variants of the sodium and chloride-dependent glycine transporter type 1 (GlyT1). These polypeptides and polynucleotides are useful in the treatment and diagnosis of disorders s... | 04/15/2008 |
| 7358057 | QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells The present invention relates e.g., to QM-7 or QT-6 cells comprising a heterologous mutant nicotinic α7 acetylcholine receptor and/or a nucleic acid encoding it, or a fragment or variant thereof. In a preferred embodiment, the mutant nicotinic α7 acetylcholine rec... | 04/15/2008 |
| 7312374 | Production of a transgenic avian by cytoplasmic injection This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred met... | 12/25/2007 |
| 7301020 | Macrolide analogs and methods for identifying same Macrolide analogs and methods for identifying macrolide analogs capable of unregulated inhibition of actin filament dynamics are provided. A method according to the invention includes the steps of: (a) contacting F-actin with a candidate compound; and (b) assaying t... | 11/27/2007 |
| 7270999 | Clock gene BMAL2 The present invention provides novel clock proteins BMAL2 (Brain-Muscle-Arnt-Like protein2), which is crucial for the clock oscillation mechanism including photic-input pathway and output pathway, novel clock genes encoding the proteins, a screening method using the... | 09/18/2007 |
| 7270990 | Virus production An improved process for recovery of virus from allantoic fluid of virus-infected chick embryos. Virus associated with granular and fibrous debris in the allantoic fluid can be disassociated from the debris and recovered, thereby increasing viral yield. Dissociation ... | 09/18/2007 |
| 7249569 | Methods for injecting avian eggs The present invention provides improved methods of injecting an avian egg containing an embryo, preferably an early embryo (e.g., a blastoderm). The methods of the invention may be used to deliver a substance to an egg, remove a sample from an egg, and/or to insert ... | 07/31/2007 |
| 7208273 | Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing drug-induced torsade de pointes or ventricular fibrillation when admin... | 04/24/2007 |
| 7199279 | Recombinant promoters in avian cells The invention provides for cells containing nucleic acids which include lysozyme gene expression controlling region nucleotide sequences which typically are linked to a polynucleotide encoding a heterologous polypeptide. ... | 04/03/2007 |
| 7157244 | Adenosine receptor The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. Th... | 01/02/2007 |
| 7145057 | Chimeric bird from embryonic stem cells Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably int... | 12/05/2006 |
| 7117814 | Method of producing avian eggs and birds of germ-free status A method of rearing a bird of germ-free status comprises housing a bird as a parent bird, surgically removing an egg in its shell from the parent bird prior to transfer of the egg to the cloaca in the parent bird, incubating the egg still in its shell and hatching t... | 10/10/2006 |
| 7074614 | Clock gene BMAL2 The present invention provides novel clock proteins BMAL2 (Brain-Muscle-Arnt-Like protein2), which is crucial for the clock oscillation mechanism including photic-input pathway and output pathway, novel clock genes encoding the proteins, a screening method using the... | 07/11/2006 |
| 7049480 | Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy The invention includes methods of enucleating avian eggs comprising visualizing internal structure of an avian egg utilizing TPLSM and ablating the nucleus of the egg by near-infrared light. ... | 05/23/2006 |
| 6897045 | Adeno-associated virus vectors The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persiste... | 05/24/2005 |
| 6875588 | Ovomucoid promoter and methods of use The present invention provides novel isolated nucleic acids comprising an avian nucleic acid sequence encoding an ovomucoid gene expression control region. The ovomucoid promoter region of the present invention allows expression of an operably linked heterologous nu... | 04/05/2005 |
| 6872561 | Immortalized avian cell lines The invention features non-transformant immortal avian cells, in particular derived from avian tissues, i.e., other than blood or hematopoietic cells, particularly fibroblasts and epithelial cells, for instance of embryos. The avian cells are immortalized by the SV4... | 03/29/2005 |
| 6864364 | MinK-related genes, formation of potassium channels and association with cardiac arrhythmia The present invention is directed to genes and gene products related to Min-K which form ion channels and to a process for diagnosis of ion channel disorders, including long QT syndrome (LQT). For example, KCNE2 forms IKr potassium channels and is associa... | 03/08/2005 |
| 6800468 | UDP-galactose: β-N-acetyl-glucosamine β1,3galactosyltransferases, β3Gal-T5 A novel gene defining a novel enzyme in the UDP-D-galactose: β-N-acetylglucosamine/β-N-acetylgalactosamine β1,3galactosyltransferase family, termed β3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of β3Gal-T5 is shown to be distin... | 10/05/2004 |
| 6723532 | Negative strand RNA viral vector having autonomous replication capability A method for reconstituting Sendai viral particles by transfecting Sendai virus to a host expressing all genes for the initial replication has been developed, enabling the Production of negative strand RNA vectors highly useful for practical applications. ... | 04/20/2004 |
| 6677137 | Avian and reptile derived polynucleotide encoding a polypeptide having heparanase activity Avian and reptile derived heparanase and nucleic acids encoding same.... | 01/13/2004 |
| 6641526 | Development of normal offspring from oocytes injected with freeze-dried spermatozoa The invention provides a method for freeze-drying spermatozoa to obtain at least one reconstituted spermatozoon whose head (nucleus) is capable of fertilizing an oocyte to produce a live offspring. The motility of spermatozoa which have been freeze-dried ... | 11/04/2003 |
| 6642042 | Producing viruses utilizing immortal avian cells The invention features apoptosis-resistant, non-transformant immortalised avian cells, in particular, avian tissues, i.e., other than blood or haematopoietic cells, particularly fibroblasts and epithelial cells, for instance embryos.... | 11/04/2003 |
| 6602686 | Compositions and method for non-targeted activation of endogenous genes The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels high... | 08/05/2003 |
| 6573097 | Method of fertilizing an avian egg in the shell The present invention relates to the field of avian egg fertilization. In particular, the present invention provides a method of fertilizing an egg in a shell. The invention also provides a method of fertilizing an egg in a shell, whereby a live chick is ... | 06/03/2003 |
| 6573069 | Crib protein ZMSE1 The present invention relates to polynucleotide and polypeptide molecules for zmse1, a novel human CRIB protein. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The present invent... | 06/03/2003 |
| 6544760 | Kunitz domain polypeptide Zkun11 Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part... | 04/08/2003 |
| 6524822 | Polynucleotide encoding human serpin Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part... | 02/25/2003 |
| 6514728 | Process for preparation of cytokines using Sendai virus expression system The present invention provides a process for preparing a cytokine inexpensively in large amounts by expressing the cytokine in a hen's egg using Sendai virus vector. The cytokine obtained by the present process is expected to be useful as medication becau... | 02/04/2003 |
| 6500668 | Culture medium for avian embryonic cells A culture medium for avian embryonic cells and an avian cell culture medium is disclosed. The culture medium is characterized in that it has elements complementary to avian embryonic cells. The complementary elements are cytokines, fibroblast growth facto... | 12/31/2002 |
| 6468776 | Human serine protease Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic... | 10/22/2002 |
| 6451549 | Secreted renilla luciferase A polynucleotide encoding a secreted form of wild type Renilla luciferase. Also provided is a polynucleotide encoding a secreted modified form of wild type Renilla luciferase. Additionally, the polypeptides encoded by the polynucleotides of the present in... | 09/17/2002 |
| 6440666 | Selection for dwarfism in poultry The invention relates to a gene located on chromosome 1 in chickens, which in birds is involved in so called autosomal dwarfism. The most likely candidate gene has a homolog in mice and men and is called HMGI-c. The sequence of the cDNA and genomic DNA of... | 08/27/2002 |
| 6410228 | Method for the identification of synthetic cell- or tissue- specific transcriptional regulatory regions The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic... | 06/25/2002 |
| 6403783 | Nucleic acid which encodes the tumor marker ZSIG62 Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular marke... | 06/11/2002 |
