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| Number | Title | Issue Date |
| 8101408 | Insecticidal extract from legume plants and method of preparing the same The invention may be summarized as follows. The present invention provides insecticides comprised of naturally-occurring compounds, such as, for example, PA1b-related peptides and terpenoid saponins. The present invention also provides for identification and charact... | 01/24/2012 |
| 8088619 | Established cell line The present invention relates to Maruca vitrata cell lines established from pupal tissues of M. vitrata, including NTU-MV, two subclones of NTU-MV: NTU-MV-1 and NTU-MV-2. The NTU-MV cell line was confirmed to be derived from M. vitrata, and NTU-... | 01/03/2012 |
| 8026096 | In vivo active erythropoietin produced in insect cells Disclosed and claimed is a human erythropoietin (EPO) expressed and produced in Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579) transfected with a baculovirus construct containing the EPO gene. The EPO has an in vivo activity of 200,000 U/mg to 500,0... | 09/27/2011 |
| 7776589 | Polynucleotides encoding polypeptide fragments of protein kinase B gamma (AKT3) The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein. ... | 08/17/2010 |
| 7718427 | Established cell lines from The present invention relates to Lymantria xylina cell lines established from pupal tissues of L. xylina Swinhoe, including NTU-LY-1, NTU-LY-2, NTU-LY-3, and NTU-LY-4. These four cell lines were confirmed to be newly established cell lines derived from... | 05/18/2010 |
| 7435808 | Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2 The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, frag... | 10/14/2008 |
| 7432419 | Compositions and methods for the treatment of Pierce's disease Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a su... | 10/07/2008 |
| 7432347 | Cytoplasmic polyhedrosis virus polyhedrin protein complex To provide a useful objective protein coated with a protective protein, a protein complex that is produced in cells and has a structure that the objective protein is occluded with the viral occlusion body protein. A protein complex having the structure that the obje... | 10/07/2008 |
| 7427658 | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have synthesized equivalent amounts of all three recombinant CAV proteins... | 09/23/2008 |
| 7425614 | Neuroprotective therapeutics preventing ERK/MAPK activation through the NMDA receptor Methods for identifying neuroprotective compounds, as well as compositions and methods for treating subjects suffering from neurological diseases or disorders are provided. ... | 09/16/2008 |
| 7416848 | DNA encoding SNORF25 receptor This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 r... | 08/26/2008 |
| 7416874 | Recombinant bacterial phytases and uses thereof A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digesti... | 08/26/2008 |
| 7413732 | Baculovirus expression system The application relates for method for cloning the gene comprising the steps of: 1. Providing a replication-deficient baculovirus vector, 2. Providing a rescue vector comprising (a) nucleic acid sequence which is capable of restoring replication in the replication-d... | 08/19/2008 |
| 7410778 | Estrogen receptor genes and utilization thereof A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid sequence of SEQ ID NO: 1, (b) an estrogen receptor comprising the amino a... | 08/12/2008 |
| 7405038 | Stable cell lines resistant to apoptosis and nutrient stress and methods of making same Cell lines that are commonly used for protein expression are engineered to include genes that encode suppressors of apoptosis (SA). Insect cell lines expressing these SA genes are resistant to apoptosis or programmed cell death, and express certain recombinant prote... | 07/29/2008 |
| 7402430 | MHC class II antigen-presenting systems and methods for activating CD4T cells The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matric... | 07/22/2008 |
| 7375205 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids... | 05/20/2008 |
| 7364866 | G protein coupled receptors, nucleic acids, and methods related to the same The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention al... | 04/29/2008 |
| 7354611 | Fecundity-promoting supplement for the insidious flower bug reared on artificial diet A new protein supplement for insect rearing contains extracts of insect eggs or cultured insect egg embryonic cell lines from insects such as Plodia interpunctella and Ephestia kuehniella Zeller, etc., to increase the fecundity of insects reared for bi... | 04/08/2008 |
| 7332303 | Product quality enhancement in mammalian cell culture processes for protein production The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal... | 02/19/2008 |
| 7294511 | Methods for delivering nucleic acid molecules into cells and assessment thereof Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial ... | 11/13/2007 |
| 7288400 | Nucleic acids encoding esterases and methods of making and using them The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased activity and stability at increased pH and temperature. ... | 10/30/2007 |
| 7285288 | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n... | 10/23/2007 |
| 7279329 | Expression system for producing collagen A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems and methods for the expression of the DNA molecule are also provided... | 10/09/2007 |
| 7273727 | Fusion proteins for prodrug activation The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is ... | 09/25/2007 |
| 7271002 | Production of adeno-associated virus in insect cells A method of producing an adeno-associated virus (AAV) in an insect cell comprising (i) providing at least one insect cell-compatible vector comprising a first nucleotide sequence comprising at least one AAV ITR nucleotide sequence, a second nucleotide sequence conta... | 09/18/2007 |
| 7270989 | Method of producing non-bovine chymosin and use hereof A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species, ovine species and caprine species; Camelidae species such as Camelu... | 09/18/2007 |
| 7267964 | DNA molecules encoding ligand gated ion channels from The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a D... | 09/11/2007 |
| 7262039 | Polypeptide This invention relates to a novel polypeptide having an α1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transfo... | 08/28/2007 |
| 7256280 | Cell cycle nucleic acids, polypeptides and uses thereof The invention provides isolated nucleic acids and their encoded proteins that are involved in cell cycle regulation. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention prov... | 08/14/2007 |
| 7253341 | Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids enc... | 08/07/2007 |
| 7247451 | Antithrombin protein and DNA sequences from black fly The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium. Methods for recombinant production of the protein as well as biomedical uses are provided. ... | 07/24/2007 |
| 7247466 | Amino acid racemase having low substrate specificity and process for producing racemic amino acid The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transfo... | 07/24/2007 |
| 7244586 | DNA molecules encoding ligand-gated ion channels from The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Drosophila melanogaster ligand-gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a ... | 07/17/2007 |
| 7226762 | Gene coding for glucose-6-phosphate-dehydrogenase proteins The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemica... | 06/05/2007 |
| 7223555 | Method for detecting elevated activity of oxidases in insects A method for checking for elevated activity of mixed-function oxidases using a single insect, includes homogenizing a single insect in an acid pH buffer, preferably by grinding it in a small tube, such as an Eppendorf tube, with a pestle, adding a buffered tetrameth... | 05/29/2007 |
| 7220576 | Methods and compositions for protein expression and purification Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed. ... | 05/22/2007 |
| 7211406 | Potassium channel A novel polypeptide which is useful in searching for a therapeutic agent for diabetes, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell transfected with the expression vector, an antibody binding to the polypeptid... | 05/01/2007 |
| 7208273 | Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing drug-induced torsade de pointes or ventricular fibrillation when admin... | 04/24/2007 |
| 7208304 | β1,3-galactosyltransferases from This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyl... | 04/24/2007 |
