Famous Patents
British merchant Peter Durand invented the tin can in 1810.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8080416 | Method for determining the immunogenicity of an antigen The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be use... | 12/20/2011 |
| 8071373 | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be use... | 12/06/2011 |
| 8030070 | Artificial lymphoid tissue equivalent The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial... | 10/04/2011 |
| 7910367 | Cell culture model and applications thereof Described is a multicellular model including at least, as cell type: keratinocytes, melanocytes, and nerve cells, in which the keratinocytes and the melanocytes form a first cell layer, a... | 03/22/2011 |
| 7741116 | Surgical device for skin therapy or testing A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, suc... | 06/22/2010 |
| 7718426 | Preparation method of a hair dermal papilla cell preparation, composition and method for regenerating hair follicles, and animal having regenerated hair follicles The present invention provides a method for preparing a hair dermal papilla cell preparation comprising preparing a cell suspension by removing epidermal tissue from skin tissue and subjecting the resulting dermal tissue fraction to collagenase treatment, and cyropr... | 05/18/2010 |
| 7326572 | Endoderm cells from human embryonic stem cells This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High qual... | 02/05/2008 |
| 7312025 | Methods and systems for extended in vitro culture of neuronal cells A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal... | 12/25/2007 |
| 7291597 | Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA and VEGF165; (ii) isolating the peripheral bl... | 11/06/2007 |
| 7288521 | Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA, VEGFB, PLGF, VEGF121, VEGF145, VEGF165, VEGF... | 10/30/2007 |
| 7282200 | Mixed-cell gene therapy The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mamma... | 10/16/2007 |
| 7279330 | Method for identifying modulating compounds of neurotransmitters A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a nerve tissue preparation and the possible modulating effect of the compo... | 10/09/2007 |
| 7252982 | Tissue engineering enhanced by the transfer of a growth factor gene Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissu... | 08/07/2007 |
| 7183095 | Cell culture system for synthesis of infectious hepatitis C virus The invention rates to a hepatitis C virus (HCV) cDNA-based culture system capable of synthesis of infectious HCV in cell culture and cell-to-cell spread of the virus. The invention also relates to a method of measuring the level of HCV infection in a hepatocyte cel... | 02/27/2007 |
| 7166280 | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease Acute and chronic heart disease is treated using a rational, multi-tier approach. A patient is pretreated with growth factor proteins or gene therapy, followed by the administration of adult stem cells. The progress of treatment is continuously monitored by echo-car... | 01/23/2007 |
| 7166278 | Modified organs and cells for xenotransplantation It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an α-galac... | 01/23/2007 |
| 7135336 | Use of oocytes a microincubators The present invention concerns methods for de-differentiation and stabilize cells, such as progenitor cells, by introducing the cells into the cytoplasm of host oocytes, such as Xenopus laevis oocytes. Advantageously, this method obviates the need for any nuc... | 11/14/2006 |
| 7101546 | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in response to glucose. These cells are advantageous in that they are both exp... | 09/05/2006 |
| 7067496 | Methods for introducing genes into mammalian subjects Methods to obtain genetic modifications of cells in histoculture are described. Modification is assisted by treating the histoculture with collagenase prior to contacting the histoculture with the delivery vehicle for the desired gene. Hair follicles and other organ... | 06/27/2006 |
| 7033831 | Islet cells from human embryonic stem cells This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High qual... | 04/25/2006 |
| 7022520 | Cell culture media for mammalian cells A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells. ... | 04/04/2006 |
| 7005127 | Mixed-cell gene therapy The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mamma... | 02/28/2006 |
| 6911201 | Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationa... | 06/28/2005 |
| 6900052 | Method of culturing cells A method of culturing a protein-producing cell, said method comprising co-culturing one transformed cell that can constitutively produce said protein with the parent cell of said transformed cell. ... | 05/31/2005 |
| 6849452 | Methods for activating natural killer (NK) cells and means for carrying out said methods The present invention relates to a process for activating natural killer cells comprising bringing NK cells into contact with dendritic cells in vitro, ex vivo or in vivo. The invention also relates to cell compositions comprising activated NK cells, NK cell-dendrit... | 02/01/2005 |
| 6849451 | Hybrid cells A rapid, simple-to-use method for preparing hybrid cells, applicable to fully differentiate, non-dividing cells, entails bringing at least two different cells into contact under conditions that promote cell fusion and then purifying the resultant hybrid without anti... | 02/01/2005 |
| 6815202 | In vitro synthesis of a layered cell sorted tissue The present invention relates to a layered cell sorted tissue that is formed in vitro. The tissue is generated by the spontaneous sorting of cells from a homogenous cell mixture into discrete layers by cell type. Connective tissue components, such as fibronectin, ma... | 11/09/2004 |
| 6803233 | Model for Alzheimer's disease and other neurodegenerative diseases The present invention provides a model for studying the development of, and/or pathologies associated with neurodegenerative diseases, and agents that can alter such development and/or pathologies. The model of the invention is especially useful as an Alzheimer's di... | 10/12/2004 |
| 6803037 | Hyaluronic acid derivative based cell culture and biodegradable three-dimensional matrix The present invention relates to a biological material having a matrix which contains at least one derivative of hyaluronic acid on which endothelial cells, glandular cells such as islets of Langerhans and liver cells, skin adnexa, germinative cells of hair bulbs, a... | 10/12/2004 |
| 6790441 | Sertoli cells as biochambers According to the present invention, there is provided a biological chamber system having a biochamber defined by outer walls of Sertoli cells. Also provided is a transplantation facilitator including a biochamber. A method of making biochambers by co-culturing facil... | 09/14/2004 |
| 6759039 | Culturing pancreatic stem cells having a specified, intermediate stage of development This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be propagated in a stable manner in successive serial passaging while maintaining insulin production in response to glucose. These cells are ad... | 07/06/2004 |
| 6750009 | Multiple viral replicon culture systems Methods and compositions are provided for screening candidate antiviral agents using cells containing subgenomic viral replication systems such as replicons and minigenomes. The methods involve the simultaneous assay of more than one subgenomic viral replication sys... | 06/15/2004 |
| 6696287 | System for co-culturing bacteria and eukaryotic cells The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and then perfused over the eukaryotic cells. The invention also ... | 02/24/2004 |
| 6673604 | Muscle cells and their use in cardiac repair Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients ha... | 01/06/2004 |
| 6652848 | Dendritic cell hybrids Immunostimulatory compositions that contain fused cells formed by fusion between dendritic cells and non-dendritic cells, methods of using these compositions, and methods of generating dendritic cell hybrids.... | 11/25/2003 |
| 6610474 | Cells for detection of influenza and parainfluenza viruses The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells which show increased sensitivity to infection by influenza... | 08/26/2003 |
| 6596474 | Prevention and treatment of amyloid-associated disorders The present invention provides assays to identify compounds that affect microglial cell activation, and specifically assays to identify compounds that affect secretion of cytokines from these microglial cells by modulating PGE2 -mediated activi... | 07/22/2003 |
| 6576466 | Tumoricidal T lymphocytes The present invention concerns a mammalian cell line which when co-cultured with lymphocytes during which allogenic stimulation is avoided activates lymphocytes fo form tumoricidal cells, a process for the production of tumoricidal T lymphocytes by co-cul... | 06/10/2003 |
| 6524855 | Methods for inducing the differentiation of monocytes into functional dendritic cells A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiati... | 02/25/2003 |
| 6514711 | Immortalized human keratinocyte cell line A method for testing the effects of various factors on human skin equivalent is disclosed. The method involves providing a human stratified squamous epithelial cell culture of an immortalized human keratinocyte cell line that forms a reconstructed epiderm... | 02/04/2003 |
