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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 8173425 | Fusion partner cells Fusion partner cells that enable production of heterohybridomas even from cells of species other than mouse were produced by fusing myeloma cells derived from a first animal species with leukemia cells derived from a second animal species, which have an extra S phas... | 05/08/2012 |
| 8114666 | Hybridoma producing antibodies to The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 02/14/2012 |
| 8114667 | Hybridoma producing antibodies to The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 02/14/2012 |
| 8058062 | Hybridoma producing antibodies to The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 11/15/2011 |
| 7799562 | Hybridoma producing antibodies to lawsonia intracellularis The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 09/21/2010 |
| 7635590 | Method of diagnosing The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 12/22/2009 |
| 7504255 | Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes The present invention provides a cell line capable producing infectious hepatitis C virus 1a (HCV 1a) particles in culture. Disclosed are compositions and methods for an HCV 1a (clone H77) transfected immortal human hepatocyte (IHH) capable of generating infectious ... | 03/17/2009 |
| 7476540 | Monoclonal antibodies to mesenchymal stem cells The present invention relates to monoclonal antibodies specifically binding to a membrane antigen of human mesenchymal stem cells, hybridoma cell lines producing the same, and methods for identifying or isolating human mesenchymal stem cells using the same. The mono... | 01/13/2009 |
| 7435801 | Antibodies and other ligands directed against KIR2DL4 receptor for production of interferon gamma The present invention provides antibodies and other ligands that specifically bind to KIR2DL4 receptor and stimulate production of interferon gamma. One embodiment is mAb #33 on deposit at ATCC. ... | 10/14/2008 |
| 7425447 | Host cells expressing 7C10 and 16C10 CD80-specific antibodies The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 recep... | 09/16/2008 |
| 7422899 | Antibodies to the human prolactin receptor This invention provides antibodies to the prolactin receptor, particularly the human prolactin receptor. Preferred antibodies are capable of blocking prolactin binding to the prolactin receptor, inhibiting signaling through the prolactin receptor, and/or inhibiting ... | 09/09/2008 |
| 7416881 | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 08/26/2008 |
| 7381800 | Antibodies to HBIMF63 polypeptide The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 06/03/2008 |
| 7371568 | Method for modifying chromosomes The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said forei... | 05/13/2008 |
| 7361345 | Anti-CD40 antibodies capable of blocking B-cell activation Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the... | 04/22/2008 |
| 7326569 | Hybrid cells producing monoclonal anti-CD14 antibodies This invention provides hybridoma cell lines producing monoclonal antibodies which inhibit CD14 mediated cell activation. Monoclonal antibodies produced by these cell lines also are provided. The antibodies are useful for the detection of the presence of cell surfac... | 02/05/2008 |
| 7323331 | Method for detecting or assaying HBV A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein o... | 01/29/2008 |
| 7317094 | Process for the in vitro culture of different stages of tissular parasites The process of the invention comprises the implementation of axenic conditions, with use of a liquid single-phase culture medium. For obtaining the amastigote forms, this medium is buffered at a pH of 5.5 to 6.5 and has an osmolarity of at least 400 milliosmoles/kg ... | 01/08/2008 |
| 7309779 | Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relat... | 12/18/2007 |
| 7273925 | Methods and products for regulating lectin complement pathway associated complement activation The invention relates to methods and products for regulating lectin complement pathway associated complement activation. The methods include both in vitro and in vivo methods for inhibiting lectin complement pathway associated complement activation. The methods are ... | 09/25/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| 7255859 | Monoclonal antibodies against the epitope YPYDVPDYA, a process for their production and their use The invention concerns monoclonal antibodies against the epitope YPYDVPDYA (SEQ ID NO: 1) which is derived from the haemagglutinin of the human influenza virus and are suitable for the detection and isolation of native haemagglutinin of the human influenza virus, of... | 08/14/2007 |
| 7247474 | Monoclonal antibody which specifically binds to but does not activate the CD8 cells This invention provides a method of isolating CD8+ cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8+ cells but does not activate the CD8+ cells once bound. This invention also pr... | 07/24/2007 |
| 7227003 | Anti-TNF antibody fragments Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as polynucleotides coding for anti-TNF murine and chimeric antibodies, pe... | 06/05/2007 |
| 7223840 | Antimicrobial peptide The present invention relates to a novel human antimicrobial peptide which is a member of the defensin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human antimicrobial peptide. Antimicrobial peptide are also provided as are v... | 05/29/2007 |
| 7223599 | Immortalization of human post-mitotic cells The present invention provides an immortalized human cardiomyocyte cell line. The present invention further provides a method for preparing a human immortalized cell line derived from a post-mitotic primary cell culture. ... | 05/29/2007 |
| 7220559 | Development of human monoclonal antibodies and uses thereof This invention provides: a heteromyeloma, other than B6B11, capable of producing a trioma when fused with a human lymphoid cell, wherein the trioma is capable of producing a monoclonal antibody-secreting tetroma when fused with a second, antibody-secreting human lym... | 05/22/2007 |
| 7208581 | TRAF family proteins In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vect... | 04/24/2007 |
| 7193064 | Anti-CD40 monoclonal antibody An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40. ... | 03/20/2007 |
| 7192582 | Human monoclonal antibodies to FC alpha receptor (CD89) Human monoclonal antibodies which bind specifically to Fc alpha receptor (CD89), including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting huma... | 03/20/2007 |
| 7179893 | Recombinant anti-TNF-α antibodies Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c... | 02/20/2007 |
| 7169565 | Antibodies to HASAV70 polypeptide The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted pr... | 01/30/2007 |
| 7163797 | 50 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 01/16/2007 |
| 7157257 | Method of treating biological cells and/or their cell components with electrical fields A method is described for treating biological cells and/or their cell components with electrical fields in a reaction medium, in which an inhibitor is added to the reaction medium to counteract the action of enzymes that break down protein. ... | 01/02/2007 |
| 7157246 | RNA polymerase I transcription factor TIF-IA The present invention relates to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, whose concentration and/or activity are correlated with the cell proliferation rate, and to DNA sequences encoding these proteins. The present invention al... | 01/02/2007 |
| 7148040 | Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides popula... | 12/12/2006 |
| 7125716 | Culturable mitochondrial cells with no nucleus, showing mitochondrial activity Provided are a method of producing a culturable cell with no nucleus, showing mitochondrial activity, comprising: performing cell fusion between a nucleus-less cell having mitochondrial DNA and a mitochondrial DNA-less cultured cell derived from a cancer cell; cultu... | 10/24/2006 |
| 7122374 | Amyloid beta-protein 3(pE)-42 antibodies and uses thereof AβN3pE-42 is a β amyloid protein that accumulates specifically as a major constituent of senile plaque in the brains of both sporadic and familial Alzheimer's disease patients. The invention provides antibodies that specifically recognize AβN3pE-4... | 10/17/2006 |
| 7118912 | Methods and compositions for categorizing patients The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detec... | 10/10/2006 |
| 7118890 | Antibodies to vertebrate delta proteins and fragments The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human prote... | 10/10/2006 |
