Class 435/344 - Binds a cancer cell or component or product thereof (e.g., cell surface antigen, etc.)

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter involving an animal cell which produces a
No. of patents: 147
Last issue date: 11/25/2008

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Number	Title	Issue Date
7456016	Cancerous disease modifying antibodies The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of...	11/25/2008
7381560	Expression and use of anti-CD20 antibodies Disclosed are immunologically active antibodies directed against the CD20 antigen, as well as host cells comprising nucleic acid sequences encoding the light chains and heavy chains of immunologically active antibodies wherein the cell is capable of expressing and s...	06/03/2008
7374765	Methods and compositions for diagnosis and treatment of iron misregulation diseases Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and antagonists. ...	05/20/2008
7374936	Method and means for site directed therapy The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates and an apparatus for radioimmunotherapy. The method, conjugates and a...	05/20/2008
7338767	Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the ...	03/04/2008
7276372	Antibodies against GPR64 and uses thereof GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types. ...	10/02/2007
7264965	Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means A complex including an HLA class I molecule and attaching means for selectively attaching the HLA class I molecule to a target is disclosed, and a method is provided for producing or enhancing an immunological response against a target cell, by attaching said comple...	09/04/2007
RE39760	Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/humans chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fr...	08/07/2007
7252994	Human DR4 antibodies and uses thereof Human Death Receptor 4 (DR4) antibodies are provided. The human DR4 antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treatment and diagnosis using the DR4 antibodies are also provided. ...	08/07/2007
7244429	Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been e...	07/17/2007
7163797	50 human secreted proteins The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote...	01/16/2007
7148038	Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treat...	12/12/2006
7125541	Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the v...	10/24/2006
7112317	Combined methods and compositions for tumor vasculature targeting and tumor treatment The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the v...	09/26/2006
7087727	Periostin-based diagnostic assays The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia. ...	08/08/2006
7070995	CE7-specific redirected immune cells Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such ...	07/04/2006
7048931	Compositions and methods for the therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a t...	05/23/2006
6924359	Neovascular-targeted immunoconjugates Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 imm...	08/02/2005
6884418	Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy This invention is directed toward novel synergistic combinations of ligand-mimicking agents specific to the c-erbB-2 protein and anti-neoplastic drugs or agents, which can be used to treat a mammalian host, usually a human, suspected of having cancer or tumor cells ...	04/26/2005
6872568	Death domain containing receptor 5 antibodies The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding...	03/29/2005
6861511	Detection and quantification of neu related proteins in the biological fluids of humans This invention relates to a substantially purified p100 which is a human neu related protein having a molecular weight in the range from about 97,000 daltons to about 115,000 daltons which corresponds substantially to the extracellular domain of the human neu gene p...	03/01/2005
6855508	ELISA for VEGF The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA method and kits for VEG...	02/15/2005
6770745	Common gamma chain blocking agents The invention relates to antibodies which specifically bind to the gc chain of cytokine receptors, as well as to cell lines which produce such antibodies, pharmaceutical compositions, and methods of treating immunological diseases by treating patients with such anti...	08/03/2004
6743898	Monoclonal antibodies that suppress B cell growth and/or differentiation The present invention provides monoclonal antibodies which interfere with the interactions between FDCs and B cells, thereby suppressing the proliferation and/or differentiation of B cells in lymphoid follicles. The monoclonal antibodies of the present invention are...	06/01/2004
6632620	Compositions for identification and isolation of stem cells The invention provides monoclonal antibodies that selectively bind to ectodermally- and endodermally-derived stem cells and methods for the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Also discl...	10/14/2003
6613538	Detection of HLA-G The present invention relates to the detection of HLA-G. Antibodies to both soluble and membrane bound HLA-G are disclosed. Exemplary antibodies include 2C/C8, 3C/G4, and 4H84. 2C/C8 and 4H84 antibodies bind to the same region of HLA-G, which is a differe...	09/02/2003
6541253	Diagnostics and therapy of diseases associated with HHV-8 infections The present invention is directed to monoclonal antibodies capable of specifically binding to and recognizing an antigenic determinant (epitope) of the protein kaposin or a derivative thereof, hybridoma cell lines producing said monoclonal antibodies, dia...	04/01/2003
6482614	Stress proteins and uses therefor The present invention relates to stress proteins and methods of modulating an individual's immune response. In particular, it relates to the use of such stress proteins in immune therapy and prophylaxis, which results in an induction or enhancement of an ...	11/19/2002
6479241	High throughput screening of the effects of anti-cancer agents on expression of cancer related genes in various cell lines A high-throughput method for screening compounds for anticancer activity involves cultivating cells capable of expressing cancer genes in cell culture in microtiter plate wells in the presence of test compounds and detecting the level of gene expression b...	11/12/2002
6447776	Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the detection and for the therapy of diffuse gastric carcinom...	09/10/2002
6440733	Monoclonal antibodies recognizing antigens on the surface of endothelial cells of tumor vessel A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing said monoclonal antibody, pharmaceutical agents comprising said monoclonal antibody, as well a...	08/27/2002
6410319	CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies Genetically engineered, CD20-specific redirected T cells expressing a cell surface protein-having an extracellular domain comprising a receptor which is specific for CD20, an intracellular signaling domain, and a transmembrane domain. Use of such cells fo...	06/25/2002
6376654	Myeloma cell and ovarian cancer cell surface glycoproteins, antibodies thereto, and uses thereof The present invention is directed to cell surface antigens found on myeloma cells and on ovarian cancer cells, and monoclonal antibodies and binding fragments thereto capable of being used for therapeutic, diagnostic, and cell purification purposes....	04/23/2002
6322787	Induction of an anti-tumor immunity by redirecting tumor cells against antigen-presenting cells According to the invention, there is provided a human or animal cell expressing an antibody directed against a surface antigen on an antigen-presenting cell (APC) and lacking parental tumor-derived immunoglobulin....	11/27/2001
6306575	Methods for preparing enriched human hematopoietic cell preparations The present invention relates to an antibody composition which contains antibodies specific for glycophorin A, CD3, CD24, CD16, CD14, and optionally CD45RA, CD38, CD36, CD38, CD56, CD2, CD19, CD66e, CD66b, and/or antibodies specific for antigens expressed...	10/23/2001
6294172	Monoclonal antibodies with specificity for membrane-associated antigens Monoclonal antibodies with specificity for membrane-associated antigens and methods of using them in detection of tumor-associated antigens arc described....	09/25/2001
6245898	Monoclonal antibodies that recognize antigens associated with tumor metastasis This invention provides tumor metastasis-inhibiting monoclonal antibodies, mAb 41-2, mAb 50-6 and mAb 1A-5. The antigen recognized by mAb 50-6 and mAb 1A-5 has been identified as the PETA-3 antigen. The antigen recognized by mAb 41-2 has been identified a...	06/12/2001
6200763	Myeloid cell leukemia associated gene mcl-1 A gene, mcl-1, of the bcl-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mcl-1 nucleotide and polypeptide sequences....	03/13/2001
6201107	Cystic fibrosis gene The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of ...	03/13/2001
6174726	Method for the immortalization of cells using conditionally transformed helper cells The invention is directed to a method for the preparation of a conditionally immortalized immortalization-helper cell (fuseme), the fusemes generated by said method, hybridoma cells prepared using said fusemes as well as a method for immortalization of ma...	01/16/2001

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Class 435/344 - Binds a cancer cell or component or product thereof (e.g., cell surface antigen, etc.)