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| Number | Title | Issue Date |
| 7390626 | Methods and kit for diagnosing tick borne illnesses ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different components of Borrelia during different cycles, including peptides f... | 06/24/2008 |
| 7067315 | Identification of anti-protozoal agents The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to identify compounds that treat or prevent protozoal infection. The pres... | 06/27/2006 |
| 7025961 | Anti-plasmodium composition and methods of use Compositions that inhibit the binding of Plasmodium falciparum to erythrocytes are provided. More particularly, antibodies specific for Plasmodium falciparum binding proteins and blocking peptides that prevent the binding of Plasmodium falciparum | 04/11/2006 |
| 6969602 | Production of an immunovariant strain of contributes to strain cross-protection with other An immunovariant strain of Eimeria maxima was isolated. Vaccines incorporating the immunovariant strain are effective in eliciting immunological protection against coccidial infection. ... | 11/29/2005 |
| 6891024 | Monoclonal antibodies to Sarcocystis neurona and uses therefor The present invention is directed to particular monoclonal antibodies that find use in the identification and purification of Sarcocystis neurona and related antigens. In particular, these antibodies permit the diagnosis of Sarcocystis related diseases... | 05/10/2005 |
| 6803035 | Anti-diarrheal and method for using the same A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal wherein the egg product is obtained from a hyperimmunized avian.... | 10/12/2004 |
| 6790937 | Recombinant scFV antibodies specific to Eimeria spp. responsible for coccidiosis The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant scFV (single chain variable fragment) antibody prepared using the variable regions; (c) a me... | 09/14/2004 |
| 6730307 | Anti-cryptosporidium parvum preparations Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for trig... | 05/04/2004 |
| 6710166 | 41 kDa Cryptosporidium parvum oocyst wall protein Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostru... | 03/23/2004 |
| 6682737 | Anti-cryptosporidium parvum preparations Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for trigger... | 01/27/2004 |
| 6635260 | Methods and compositions for prevention and treatment of Clostridium difficile-associated diseases This invention provides methods and compositions for preventing and treating Clostridium difficile-associated disease in a subject, wherein the subject is either a human or non-human animal. The method comprises administering to the subject an effective a... | 10/21/2003 |
| 6521229 | 41 kDa Cryptosporidium parvum oocyst wall protein Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colo... | 02/18/2003 |
| 6451984 | Chicken monoclonal antibodies specific for coccidial antigens involved in invasion of host lymphocytes A stable chicken hybridoma secreting a monoclonal antibody (mAb) that detects the conoid structure of Eimeria acervulina (E. acervulina) sporozoites has been developed. The hybridoma is made by fusing a thymidine kinase (TK)-deficient chicken myeloma with... | 09/17/2002 |
| 6417341 | Malaria merozoite antigen subunit vaccine An immunogenic polypeptide for use in inducing an immune response against Plasmodium infection comprises an amino acid sequence corresponding to a non-full length fragment of the apical membrane antigen 1 (AMA-1) of Plasmodium species which does not inclu... | 07/09/2002 |
| 6413721 | Methods of isolating common and specific antigens from excretory-secretory products of protostrongylidae Novel Protostrongylidea antigens and early and accurate diagnostic methods for Protostrongylidae infection are disclosed. Novel P. tenuis-specific antigens and methods of discriminating between P. tenuis infection and infection with other closely-related ... | 07/02/2002 |
| 6391569 | Method to detect Dirofilaria immitis infection The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in ... | 05/21/2002 |
| 6277973 | Cloning and expression of a DNA sequence encoding a 41 kDa cryptosporidium parvum oocyst wall protein Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colo... | 08/21/2001 |
| 6110463 | Anti-Cryptosporidium parvum preparations Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for trigger... | 08/29/2000 |
| 6060281 | Parasitic helminth PLA2 proteins and nucleic acid molecules The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth p... | 05/09/2000 |
| 5906936 | Endowing lymphocytes with antibody specificity There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same s... | 05/25/1999 |
| 5840580 | Phenotypic characterization of the hematopoietic stem cell One or more population of cells enriched for human hematopoietic stem cells is disclosed. HSC in this population of cells are capable of limited self-renewal and are capable of differentiating into all elements of the hematopoietic system. This population... | 11/24/1998 |
| 5840297 | Vaccine comprising anti-idiotypic antibody to chlamydia GLXA and process A genus specific chlamydia vaccine is provided which comprises an anti-idiotype antibody capable of producing in an animal an anti-anti-idiotypic antibody which recognizes a glycoplipid exoantigen (GLXA) of chlamydia. The vaccine is produced by producing ... | 11/24/1998 |
| 5747294 | Compositions and methods for the prevention and diagnosis of lyme disease Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme ... | 05/05/1998 |
| 5648267 | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same Disclosed herein are fully impaired consensus Kozak sequences which are most typically used with dominant selectable markers of transcriptional cassettes which are a part of an expression vector. These vectors are most typically utilized in the expression... | 07/15/1997 |
| 5643737 | Merozoite proteins for use in detection of Babesia equi in horses using immunological techniques The present invention relates to a purified and isolated merozoite protein which is a specific indicator of infection by Babesia equi (B. equi) in horses. This protein contains a conserved region found in all strains of B. equi. It has a molecular weight ... | 07/01/1997 |
| 5502168 | Monoclonal antibodies to a continuous and cross-reactive epitope and an isolated protein of a sexual stage of P. falciparum Monoclonal antibodies which recognize a continuous epitope in the sexual stages of P. falciparum. The epitope so recognized has the following amino acid sequence: ##STR1## Malaria vaccines based on this epitope are also disclosed.... | 03/26/1996 |
| 5478741 | Antibodies to the HRPII protein of plasmodium falciparum Antibodies which recognize and bind to histidine rich protein II of Plasmodium falciparum. These antibodies exhibit improved specificity and affinity for the antigen which provides enhanced sensitivity in immunoassays. Peptides useful for generation of th... | 12/26/1995 |
| 5279822 | Monoclonal antibodies against the 28KD protein of S. mansoni A hybridoma is provided which provides a monoclonal antibody of isotope IgG2a, which recognizes a strip corresponding to a peptidic fragment of 8kD, isolated by controlled proteolysis of the 28kD polypeptide of S. mansoni.... | 01/18/1994 |
| 5019511 | Erythrocytic membrane antigens of P. falciparum-infected erythrocytes Monoclonal antibodies are disclosed that react with an antigenic polypeptide having a molecular weight of approximately 45,000 that is expressed in the cell membrane of P. falciparun-infected erythrocytes. The antibodies were raised using the Honduras CDC... | 05/28/1991 |
| 5008198 | Merozoite surface glycoproteins The invention comprises antigenic glycoproteins substantially similar to antigenic glycoproteins present on the surface of the merozoite form of Plasmodium falciparum, including glycoproteins of molecular weights of about 56,000 present in the Geneva and ... | 04/16/1991 |
| 5004694 | Complement-dependent cytolytic anti-Trichomonas vaginalis monoclonal antibodies Novel monoclonal antibodies specific to Trichomonas vaginalis, having complement--fixing ability and lysing Trichomonas vaginalis in the presence of complement are disclosed and may be used in therapy and diagnosis of trichomoniasis. Hybridomas producing ... | 04/02/1991 |
| 5001225 | Monoclonal antibodies to a pan-malarial antigen A continuous hybridoma cell line, designated 7H8, which secretes a monoclonal antibody (MAb 7H8) of the IgM class and which binds to a protein present in species of the genus Plasmodium. MAb 7H8 also recognizes an antigen (antigen Pf93) unique to P. falci... | 03/19/1991 |
| 4897354 | Monoclonal antibody-specific merozoite antigens Disclosed herein is a P. falciparum merozoite antigenic polypeptide of approximate molecular weight 185,000. The polypeptide and processing fragments are specific to, and isolable using, a monoclonal antibody produced by hybridoma cell line HB 9148. The p... | 01/30/1990 |
| 4746612 | Aotus interspecies hybridomas and monoclonal receptors produced thereby Aotus trivirgatus interspecies hybridomas, their monoclonal receptors and methods of preparation and use are disclosed. The hybridomas are prepared by fusion of Aotus antibody-producing cells with myeloma cells containing about an equal number of chromoso... | 05/24/1988 |
| 4707442 | Hybrid cell line producing monoclonal antibody cytolytic to Trichomonas vaginalis Hybridomas secreting monoclonal antibody having specificity for and cytolytic against Trichomonas vaginalis are provided. The cytolytic monoclonal antibodies specific for T. vaginalis are useful in detecting the presence of T. vaginalis among a general po... | 11/17/1987 |
| 4670384 | Diagnostic reagent for swine trichinosis A hybrid cell formed by the fusion of a mouse spleen cell with a mouse myeloma cell secretes an IgM class antibody. The antibody is useful as a preparative reagent in the isolation of three proteins, molecular weights 45,000, 49,000 and 53,000, from the p... | 06/02/1987 |
| 4632909 | Monoclonal antibodies which block infectivity of malarial parasites to mosquitoes Monoclonal antibodies have been developed that bind with one or more proteins located on the surface of gametes or zygotes of malaria parasites. These antibodies are specific for antigens on mosquito midgut stages of malaria parasite and sterilize the par... | 12/30/1986 |
| 4530908 | Diagnosis and treatment of fluke infections with monoclonal antibodies Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. A diagnostic method for the determination of an active fluke infection in a warm-blooded animal is provided which comprises the testing of body ser... | 07/23/1985 |
