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Actor Marlon Brando has four patents, all named "Drumhead tensioning device and method."
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| Number | Title | Issue Date |
| 7442550 | Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envel... | 10/28/2008 |
| 7323557 | Genome of the HIV-1 inter-subtype (C/B') and use thereof The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The pre... | 01/29/2008 |
| 7311920 | Virus coat protein/receptor chimeras and methods of use The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can interact with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charact... | 12/25/2007 |
| 7223844 | Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody ... | 05/29/2007 |
| 7189826 | Monoclonal human natural antibodies Disclosed herein are hydridoma cell lines producing monoclonal human natural IgM antibodies and methods of use thereof. The antibodies are the monoclonal equivalents of circulating human natural antibodies. Also disclosed herein are pharmaceutical formulations and m... | 03/13/2007 |
| 7090848 | HIV-1 envelope protein associated with a broadly reactive neutralizing antibody response The present invention relates to HIV-1 envelope proteins from a donor with non-progressive HIV-1 infection whose serum contains broadly cross-reactive, primary virus neutralizing antibody. The invention also relates to isolated or purified proteins and protein fragm... | 08/15/2006 |
| 7056735 | Mimetics and inhibitors of the interaction between Vpr (HIV viral protein of regulation) and ANT (Mitochondrial adenine nucleotide translocator) The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleot... | 06/06/2006 |
| 7041293 | HIV env antibodies The invention provides antibodies specific for HIV env, including monoclonal antibodies and related hybridomas. The antibodies block CD4/g120 binding and reduce reverse transcriptase activity in vitro. ... | 05/09/2006 |
| 6949337 | Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle The present invention provides methods of identifying anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment thereof known to interact with hVIP in the presence of a test compou... | 09/27/2005 |
| 6927023 | Method of identifying modulators of HIV-1 Vpu and Gag interaction with U binding protein (Ubp) A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is also disclosed. ... | 08/09/2005 |
| 6908734 | Sulfated CCR5 peptides for HIV-1 infection This invention provides a compound comprising the structure: θαYDINYYTSEβλ wherein each T represents a threonine, each S represents a serine, each E represents a glutamic acid, each Y represents a tyrosine; each D represents an aspartic acid, each I represents a... | 06/21/2005 |
| 6893813 | Methods for treatment of HIV and other infections using a T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods for expandin... | 05/17/2005 |
| 6821723 | GP41 antigen The present invention comprises novel polypeptide antigens that can be used for therapeutic and prophylactic immunization against HIV-related infections. The polypeptide of the invention mimics the intermediate state of gp41 and is capable of inducing antibodies whi... | 11/23/2004 |
| 6821744 | Method, assay, and kit for quantifying HIV protease inhibitors A method for quantifying an HIV protease inhibitor in a sample includes combining HIV protease, a conjugate comprising an HIV protease inhibitor analog, and a sample suspected of containing an HIV protease inhibitor. The HIV protease and the conjugate are capable of... | 11/23/2004 |
| 6818392 | Monoclonal antibodies to human immunodeficiency virus and uses thereof The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 11/16/2004 |
| 6815201 | HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies The invention features a protein which includes a gp120 V1/V2 domain of an HIV-1 strain and not a gp120 V3 domain of an HIV-1 strain, which protein does not substantially bind CD4. The gp120 V1/V2 domain of the protein displays an epitope which is recognized by an a... | 11/09/2004 |
| 6812025 | Two hybrid assay that detects HIV-1 reverse transcriptase dimerization This invention provides methods of determining whether a compound inhibits HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse tran... | 11/02/2004 |
| 6812026 | Antibodies directed against binding-associated epitopes Binding of two members of a binding couple reveal epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher affinit... | 11/02/2004 |
| 6783939 | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof o... | 08/31/2004 |
| 6733993 | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications First generation adenoviral vectors and associated recombinant adenovirus-based HIV vaccines which show enhanced stability and growth properties and greater cellular-mediated immunity are described within this specification. These adenoviral vectors are utilized to ... | 05/11/2004 |
| 6709811 | Versatile reagent for detecting murine leukemia viruses A method for detecting broad spectrum of murine leukemia viruses belonging to any or all of the ecotropic, xenotropic, polytropic and amphotropic groups, has been described. The method utilizes a monoclonal antibody designated 83A25 which identifies almost all class... | 03/23/2004 |
| 6703019 | Cationized antibodies against intracellular proteins The subject application discloses methods and compositions for the targeted detection and/or inhibition of an intracellular protein in a cell by contacting the cell with a cationized antibody which reacts specifically with the intracellular protein. An ex... | 03/09/2004 |
| 6696291 | Synthetic HIV gag genes Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effec... | 02/24/2004 |
| 6670181 | Compositions and methods for treating viral infections Methods and compositions for treatment, diagnosis, and prevention of a virus comprise administering to a patient antibodies which react with regions of viral proteins and result in neutralization of infectivity and inactivation of functionally essential e... | 12/30/2003 |
| 6670466 | Human endogenous retrovirus in breast cancer The present invention is related to mammary tumor virus (MTV). MTV represents a group of retroviruses which possess very high homology to mouse mammary tumor virus (MMTV), a virus known to cause neoplastic mammary disease in mice. As described herein, MTV... | 12/30/2003 |
| 6653130 | Method for the development of an HIV vaccine Human immunodeficiency virus (HIV) comprising reverse transcriptase inactivated by photoinactivation used to evoke an immune response. The immune response may protect an individual from challenges with live virus. Alternatively, the inactivated HIV partic... | 11/25/2003 |
| 6649409 | Method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate and synthetic envelope BX08 constructs The present invention relates to a method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate. Specific such nucleotide sequence construct are the synthetic envelope BX08 con... | 11/18/2003 |
| 6649410 | Method for the development of an HIV vaccine Human immunodeficiency virus (HIV) comprising reverse transcriptase inactivated by photoinactivation. The inactivated virus may be more safely handled, stored, and analyzed, used in diagnostic procedures and kits, and may be used as an immunogen to evoke ... | 11/18/2003 |
| 6605427 | Assay for detection of viral fusion inhibitors The invention is directed to a methods for identifying compounds that inhibit or prevent infection of cells by enveloped viruses such as HIV-1 by preventing or disrupting conformational changes in the viral transmembrane protein that are required for viru... | 08/12/2003 |
| 6551824 | Retrovirus from the HIV group and its use A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it a... | 04/22/2003 |
| 6498006 | Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods f... | 12/24/2002 |
| 6482614 | Stress proteins and uses therefor The present invention relates to stress proteins and methods of modulating an individual's immune response. In particular, it relates to the use of such stress proteins in immune therapy and prophylaxis, which results in an induction or enhancement of an ... | 11/19/2002 |
| 6479284 | Humanized antibody and uses thereof A humanized antibody framework motif is described. Preferably, the motif is encoded by the VH gene of K5B8 and the VL gene of TR1.6. This humanized antibody preferably contains the variable region of a tat antibody.... | 11/12/2002 |
| 6465173 | Anti-idiotypic antibody and its use in diagnosis and therapy in HIV-related disease The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods ... | 10/15/2002 |
| 6448375 | Active and inactive CC-chemokine receptor A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic acid sequences listed as SEQ ID NO:1, SEQ ID NO:2 and SEQ ID ... | 09/10/2002 |
| 6448078 | Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle The present invention is directed to substantially pure Human Vpr Interacting Protein (hVIP), and fragments thereof. Also disclosed are isolated nucleic acid molecules that encode hVIP, or a fragment thereof; nucleic acid probes and primers directed to nu... | 09/10/2002 |
| 6432714 | Prophylactic and therapeutic method Antigenic and/or immunoregulatory material derived from Mycobacterium vaccae is useful in the prophylaxis or therapy of AIDS with or without associated tuberculosis.... | 08/13/2002 |
| 6410318 | Antibodies directed against binding-associated epitopes Binding of two members of a binding couple reveals epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher af... | 06/25/2002 |
| 6406911 | Compositions and methods for sensitive detection of HIV infection and monitoring of drug resistance A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or more additional cell surface receptors necessary to allow ... | 06/18/2002 |
| 6403300 | Monoclonal antibodies for detection of friend murine leukemia virus The present invention relates to Friend murine leukemia virus (F-MuLV) specific monoclonal antibodies, or binding fragments thereof, specific for an antigenic determinant of a gp85 envelope precursor protein characteristic of a methanol-fixed F-MuLV infec... | 06/11/2002 |
