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| Number | Title | Issue Date |
| 7413899 | Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequ... | 08/19/2008 |
| 6927035 | Antiuracil monoclonal antibody A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying uracil or thymine characterized by using the above-described monoclonal... | 08/09/2005 |
| 6815169 | Identification and expression of a novel kinesin motor protein The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for screening for TL-γ modulators. ... | 11/09/2004 |
| 6800468 | UDP-galactose: β-N-acetyl-glucosamine β1,3galactosyltransferases, β3Gal-T5 A novel gene defining a novel enzyme in the UDP-D-galactose: β-N-acetylglucosamine/β-N-acetylgalactosamine β1,3galactosyltransferase family, termed β3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of β3Gal-T5 is shown to be distin... | 10/05/2004 |
| 6683171 | Identification of the gene causing the mouse scurfy phenotype and its human ortholog Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utili... | 01/27/2004 |
| 6623960 | Agents that bind to and inhibit human cytochrome P450 2C8, 2C9, 2C18 and 2C19 The invention provides monoclonal antibodies to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of s... | 09/23/2003 |
| 6277561 | Diagnostic assay for detection of HIV A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it a... | 08/21/2001 |
| 6197582 | Development of human monoclonal antibodies and uses thereof The present invention provides a trioma cell which does not produce any antibody obtained by fusing a hetermomyeloma cell which does not produce any antibody with a human lymphoid cell, wherein the heteromyeloma cell is designated B6B11. The invention als... | 03/06/2001 |
| 6194180 | Nucleic acid enzymes for cleaving DNA The present invention discloses nucleic acid enzymes capable of cleaving single-stranded DNA in a site specific manner.... | 02/27/2001 |
| 6075127 | Preparation of purified (poly)peptides The invention provides for a method for the modification of (poly)peptides for facilitating purification thereof, which modification method comprises the insertion of at least one specifically cleavable amino acid at the end of the (poly)peptide chain dur... | 06/13/2000 |
| 5942390 | Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism A novel, differential association between allele 2 of the variable number of tandem repeats polymorphism at intron 2 of the human IL-1 receptor antagonist gene and ulcerative colitis in humans of Jewish ancestry has been discovered. In accordance with the... | 08/24/1999 |
| 5914394 | Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders The present invention relates to the mammalian fsh16 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh16 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh1... | 06/22/1999 |
| 5851829 | Method of intracellular binding of target molecules The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably a protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is de... | 12/22/1998 |
| 5834214 | Detection of pancreatitis-associated protein for screening for cystic fibrosis The invention relates to in vitro detection of human pancreatitis-associated protein (hPAP) for the purpose of screening for cystic fibrosis. hPAP is quantitated in a biological sample, preferably blood, and a high value is indicative of pancreatic dysfun... | 11/10/1998 |
| 5736395 | Amphiphilic imidazolinium derivatives Amphiphiles containing an imidazdinium ring system are provided that are non-toxic to the host mammal. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules intracellularly.... | 04/07/1998 |
| 5721341 | Derivatives of nucleosides, processes for the production of these derivatives of nucleosides and specific polyclonal and monoclonal antibodies of these derivatives The invention relates to derivatives of nucleosides, processes for the production of these derivatives of nucleosides, as well as specific polyclonal and monoclonal antibodies of the aforementioned derivatives. These derivatives comply with the following chemi... | 02/24/1998 |
| 5221611 | ddI immunoassays, derivatives, conjugates and antibodies This invention relates to a method for the immunoassay of ddI (2',3'-dideoxyinosine), also known as didanosine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel analog... | 06/22/1993 |
| 5192683 | Monoclonal antibodies to cruciform DNA structure The present invention relates to monoclonal antibodies of class IgG1 and IgM possessing among others the property to bind to stable heteroduplex cruciform DNA structures constructed from two DNA plasmids, to the hybrid cell lines producing such antibodies... | 03/09/1993 |
| 4929544 | Reagents, methods, and test kit for diagnosing/monitoring cancer in humans Human cancer is diagnosed/monitored by measuring the levels of N-[9-(ଲ-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine (t6 A), in a physiological fluid specimen of a subject by a quantitative immunoassay that employs a monoclonal anti-t | 05/29/1990 |
| 4923813 | Monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde or acrolein Monoclonal antibodies specific for the 8R,6R- and 8S,6S-stereoisomers of 3-(2-deoxy-ଲ-D-erythropentofuransyl)-5,6,7,8-tetrahydro-8-hydroxy-6-m ethylpyrimido[1,2-a]purine-10(3H)one were produced. These cyclic 1,N2 -propanodeoxyguanosines ar... | 05/08/1990 |
| 4865980 | Monoclonal antibodies for DNA-RNA hybrid complexes and their uses Monoclonal antibodies are provided capable of distinguishing DNA-RNA hybrid complexes from single stranded DNA and RNA and double stranded DNA and RNA. The antibodies find particular use in determining the presence of a specific nucleic acid sequence on a... | 09/12/1989 |
| 4833084 | Monoclonal antibody specific for DNA.RNA hybrids A monoclonal antibody specific for DNA.multidot.RNA duplexes, particularly DNA.multidot.RNA heteropolymer duplexes, characterized by having cross-reactivity for binding to single- or double-stranded DNA or RNA as measured by competitive immunoassay of les... | 05/23/1989 |
| 4812397 | MAB-anti-DNA related to nephritis Novel compositions and methods are provided for detecting lupus nephritis in patients suffering from SLE. Competitive or non-competitive assays may be employed, where monoconal antibodies may be used to compete with antiserum for a nucleic acid ligand or ... | 03/14/1989 |
| 4623627 | Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same Monoclonal antibodies having conformation-dependent specificity for native dsDNA, as exemplified by the IgM antibody produced by murine hybridoma ATCC No HB 8329. These antibodies are used to detect DNA duplex formation in DNA hybridization tests.... | 11/18/1986 |
