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| Number | Title | Issue Date |
| 8143057 | Chelating agents and highly luminescent and stable chelates and their use This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relat... | 03/27/2012 |
| 8093045 | Fed-batch cell culture methods using non-animal-based hydrolysates The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and com... | 01/10/2012 |
| 7585671 | Hedgehog interacting proteins and uses related thereto The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the v... | 09/08/2009 |
| 7425447 | Host cells expressing 7C10 and 16C10 CD80-specific antibodies The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 recep... | 09/16/2008 |
| 7422899 | Antibodies to the human prolactin receptor This invention provides antibodies to the prolactin receptor, particularly the human prolactin receptor. Preferred antibodies are capable of blocking prolactin binding to the prolactin receptor, inhibiting signaling through the prolactin receptor, and/or inhibiting ... | 09/09/2008 |
| 7419807 | protein, gene sequence and uses thereof A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeu... | 09/02/2008 |
| 7399470 | Sandwich immunoassay kits for detecting ciguatoxin CTX3C A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of t... | 07/15/2008 |
| 7390626 | Methods and kit for diagnosing tick borne illnesses ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different components of Borrelia during different cycles, including peptides f... | 06/24/2008 |
| 7381412 | Anti-TECK antibodies and methods of use therefor The invention relates to antibodies or antigen-binding fragments thereof which binds the chemokine mammalian TECK and inhibit binding of the chemokine to mammalian GPR-9-6. The invention also relates to host cells that produce such antibodies or antigen-binding frag... | 06/03/2008 |
| 7381561 | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided. ... | 06/03/2008 |
| 7368256 | Antibodies against and methods for their use Antibodies to various fungal antigens are disclosed, including monoclonal antibody 9B4 that selectively binds an antigen of Stachybotrys chartarum spores not found in Stachybotrys chartarum mycelium. The antibodies may be used in a variety of methods, ... | 05/06/2008 |
| 7361345 | Anti-CD40 antibodies capable of blocking B-cell activation Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the... | 04/22/2008 |
| 7344848 | Methods for determining adequacy of heat processing of a cooked meat sample Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point temperature o... | 03/18/2008 |
| 7326419 | Surface protein of The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 02/05/2008 |
| 7309489 | Mouse CD40 ligand-specific antibodies and hybridomas There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding r... | 12/18/2007 |
| 7303914 | Monoclonal antibody against human hepatoma and use thereof The present invention provides a monoclonal antibody MF4C4 against human hepatoma marker antigen. This monoclonal antibody is characterized by high specifically binding to the hepatoma antigen. The present invention also provides MF4C4 immunoglobulins, and the fragm... | 12/04/2007 |
| 7264967 | Anti-CD14 monoclonal antibody having effect of inhibiting CD14/TLR binding The present invention provides an antibody which specifically recognizes an epitope containing a part of a domain based on a finding that the domain ranging from the 269- to 315-positions of human CD14 represented by SEQ ID NO:1 is a site capable of interacting with... | 09/04/2007 |
| 7264965 | Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means A complex including an HLA class I molecule and attaching means for selectively attaching the HLA class I molecule to a target is disclosed, and a method is provided for producing or enhancing an immunological response against a target cell, by attaching said comple... | 09/04/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| RE39760 | Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/humans chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fr... | 08/07/2007 |
| 7252959 | Assays for diagnosis of thrombophilic disease The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of the invention are premised on the inhibition of binding of an antico... | 08/07/2007 |
| 7250492 | Compositions and methods for inhibition of cancer invasion and angiogenesis The invention provides antibodies that specifically bind a membrane protease complex, the complex consisting of two homodimers of seprase and dipeptidyl peptidase IV (DPPIV), obtained from mammalian, preferably human cell membranes. The antibodies specifically bind ... | 07/31/2007 |
| 7247476 | Individualized anti-cancer antibodies The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production o... | 07/24/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7227003 | Anti-TNF antibody fragments Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as polynucleotides coding for anti-TNF murine and chimeric antibodies, pe... | 06/05/2007 |
| 7227004 | Antibodies to vascular endothelial cell growth factor The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related protein. The invention also provides hybridoma cell lines that produce suc... | 06/05/2007 |
| 7223844 | Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody ... | 05/29/2007 |
| 7220411 | Compositions comprising anti-CCR5 antibody This invention provides a composition for inhibiting HIV-1 infection comprising at least two compounds in synergistically effective amounts for inhibiting HIV-1 infection, wherein at least one of the compounds prevents the productive interaction between HIV-1 and an... | 05/22/2007 |
| 7193064 | Anti-CD40 monoclonal antibody An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40. ... | 03/20/2007 |
| 7179893 | Recombinant anti-TNF-α antibodies Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c... | 02/20/2007 |
| 7157088 | Surface protein of The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 01/02/2007 |
| 7147851 | Humanized immunoglobulin reactive with α4β7 integrin The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework reg... | 12/12/2006 |
| 7148038 | Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treat... | 12/12/2006 |
| 7128905 | Method of treating graft versus host disease by administration of a Fas antagonist The present invention is drawn to methods of preventing and treating diseases wherein the involvement of apoptosis has been indicated. ... | 10/31/2006 |
| 7125541 | Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the v... | 10/24/2006 |
| 7112317 | Combined methods and compositions for tumor vasculature targeting and tumor treatment The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the v... | 09/26/2006 |
| 7108854 | Surface proteins of The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 09/19/2006 |
| 7109183 | Phosphohalohydrins, process for the production thereof and use thereof The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among ... | 09/19/2006 |
| 7087727 | Periostin-based diagnostic assays The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia. ... | 08/08/2006 |
| 7067109 | Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-t... | 06/27/2006 |
