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| Number | Title | Issue Date |
| 8071372 | Tumor endothelial marker 5α molecules and uses thereof The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention fu... | 12/06/2011 |
| 7547544 | Antibodies against GPR64 and uses thereof GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types. ... | 06/16/2009 |
| 7527973 | Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associ... | 05/05/2009 |
| 7485459 | Human neuronal attachment factor-1 antibodies A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral... | 02/03/2009 |
| 7432358 | Oncogene, recombinant protein derived therefrom, and uses thereof The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an ... | 10/07/2008 |
| 7425327 | Choline binding proteins for anti-pneumococcal vaccines The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococc... | 09/16/2008 |
| 7410648 | Polypeptides of () The present invention relates to polypeptides, more particularly polypeptides of Moraxella (Branhamella) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (Branhamella) catarrhalis infection. ... | 08/12/2008 |
| 7390626 | Methods and kit for diagnosing tick borne illnesses ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different components of Borrelia during different cycles, including peptides f... | 06/24/2008 |
| 7357927 | Death domain containing receptors The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 prote... | 04/15/2008 |
| 7342105 | Antibody and use thereof The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic ag... | 03/11/2008 |
| 7332171 | 28 kDa outer membrane protein multigene family The 28-kDa outer membrane proteins (P28) of Ehrlichia chaffeensis are encoded by a multigene family consisting of 21 members located in a 23-kb DNA fragment in the genome of E. chaffeensis. Fifteen of these proteins are claimed herein as novel sequence... | 02/19/2008 |
| 7326419 | Surface protein of The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 02/05/2008 |
| 7320790 | Humanized antibodies Humanized forms of mouse antibody 10D5 that retain the binding properties of mouse 10D5 are disclosed. Also disclosed are processes for making the humanized antibody, intermediates for making the humanized antibodies, including, nucleotide sequences, vectors, transf... | 01/22/2008 |
| 7318923 | Humanized anti-βantibodies Humanized forms of mouse antibody 3D6 that retain the binding properties of mouse 3D6 are disclosed. Also disclosed are processes for making the humanized antibody, intermediates for making the humanized antibodies, including, nucleotide sequences, vectors, transfor... | 01/15/2008 |
| 7314722 | Cytostatin II antibodies and methods The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention... | 01/01/2008 |
| 7309780 | Antibodies to natural killer cell activating factor II The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to meth... | 12/18/2007 |
| 7276372 | Antibodies against GPR64 and uses thereof GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types. ... | 10/02/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7238788 | Antibodies to phosphorylated tau, methods of making and methods of use Disclosed are antibodies to phosphorylated tau, methods of making and methods of use. ... | 07/03/2007 |
| 7226749 | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according... | 06/05/2007 |
| 7220411 | Compositions comprising anti-CCR5 antibody This invention provides a composition for inhibiting HIV-1 infection comprising at least two compounds in synergistically effective amounts for inhibiting HIV-1 infection, wherein at least one of the compounds prevents the productive interaction between HIV-1 and an... | 05/22/2007 |
| 7211645 | PRO268 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 05/01/2007 |
| 7176290 | Tools for the diagnosis and treatment of Alzheimer's disease The present invention relates to phosphorylated tau protein epitopes associated with Alzheimer's disease, to protein kinases responsible for tau protein epitope phosphorylation, and to antibodies specific for the tau epitopes. Additionally, the present invention rel... | 02/13/2007 |
| 7157088 | Surface protein of The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 01/02/2007 |
| 7138247 | Compositions and methods for detecting stress-inducible proteins Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ... | 11/21/2006 |
| 7135284 | Primer extension methods for production of high specific activity nucleic acid probes The present invention provides novel nucleic acid labeling techniques that generate nucleic acid probes with specific activities at least ten fold higher than the levels obtained using standard labeling methods. Specifically, the methods of the invention provides me... | 11/14/2006 |
| 7132281 | Methods and host cells for producing human monoclonal antibodies to CTLA-4 In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, ... | 11/07/2006 |
| 7129324 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 10/31/2006 |
| 7129325 | Pro9836 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 10/31/2006 |
| 7125962 | Anti-Pro268 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 10/24/2006 |
| 7122374 | Amyloid beta-protein 3(pE)-42 antibodies and uses thereof AβN3pE-42 is a β amyloid protein that accumulates specifically as a major constituent of senile plaque in the brains of both sporadic and familial Alzheimer's disease patients. The invention provides antibodies that specifically recognize AβN3pE-4... | 10/17/2006 |
| 7118912 | Methods and compositions for categorizing patients The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detec... | 10/10/2006 |
| 7108853 | Surface protein of Leptospira The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 09/19/2006 |
| 7108854 | Surface proteins of The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods. ... | 09/19/2006 |
| 7105642 | Monoclonal antibodies specific for phosphorylated estrogen receptor alpha (Ser118) and uses thereof The invention provides monoclonal antibodies that bind the estrogen receptor α (ER α) when phosphorylated at serine 118 (Ser118) in the N-terminal domain, but do not bind to ER α when not phosphorylated at this site. Also provided are methods for determining the ... | 09/12/2006 |
| 7101979 | Antibodies to antiangiogenic compositions and methods Antibody to endostatin protein that is an inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 18 kDa as determined by non-reduced gel electrophoresis, and approximately 20 kDa as determi... | 09/05/2006 |
| 7101962 | Antibodies of the P2Y10 receptor useful in altering T lymphocyte function The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of acti... | 09/05/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7056702 | Detecting lipocalin The invention provides antibodies reactive with distinct lipocalin epitopes that are useful for detecting inflammation and bacterial infections in mammals. ... | 06/06/2006 |
