Class 435/330 - Immunoglobulin or antibody binds an expression product of a cancer related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter involving an animal cell which produces an
No. of patents: 131
Last issue date: 04/24/2012

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Number	Title	Issue Date
8163552	Adenocarcinoma specific antibody SAM-6, and uses thereof A purified polypeptide that binds to neoplastic cells, which may be an antibody, is produced by the hybridoma SAM-6, a method for its production and use in the treatment and diagnosis of neoplasms. ...	04/24/2012
8062887	Monoclonal antibody specifically recognizing modification site after translation of p53 and kit for assaying modification site containing the same The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody whi...	11/22/2011
7781212	Antitumor antibodies, proteins, and uses thereof Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies. ...	08/24/2010
7579187	Anti-A33 antibody The present invention provides: an antibody or a antibody fragment thereof, which can bind to A33, which specifically attacks A33-expressing tumor cells with the use of ADCC and CDC based on the immune system, and for which no HAHA is produced; and a preventive or t...	08/25/2009
7537931	Humanized anti-ERBB2 antibodies and treatment with anti-ERBB2 antibodies The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies. ...	05/26/2009
7435590	Monoclonal antibody and hybridoma producing the same The present invention establishes a simple and a highly sensitive detection method for hEPR and provides a novel detection method for human tumors which express hEPR. In particular, the present invention provides a monoclonal antibody which specifically recognizes h...	10/14/2008
7413899	Genes from the 20q13 amplicon and their uses The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequ...	08/19/2008
7405061	Antigen PIPA and antibodies that bind thereto Provided herein is disclosure about the identification and characterization of disease and cancer associated antigen PIPA. The invention also provides a family of monoclonal antibodies that bind to antigen PIPA, and methods of diagnosing and treating various human c...	07/29/2008
7374936	Method and means for site directed therapy The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates and an apparatus for radioimmunotherapy. The method, conjugates and a...	05/20/2008
7351583	Antibodies to G protein-coupled receptor A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted ...	04/01/2008
7335747	Cancer associated gene mina 53, protein Mina 53 and monoclonal antibody thereof Myc protein is an unevenly distributed intermediate agent for cell proliferation, and activates a gene expression via E.box. Mina53 gene encodes a protein of 53 kDa molecular weight and is present in the nucleoplasm and nucleolus. Mina53 mRNA and protein expression ...	02/26/2008
7319139	TAG-72 specific C2 domain deleted antibodies Methods, compositions and kits comprising dimeric antibodies for the treatment of neoplastic, autoimmune or other disorders are provided. The dimeric antibodies of the instant invention may comprise two antibody molecules (H4L4) having the same...	01/15/2008
7276372	Antibodies against GPR64 and uses thereof GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types. ...	10/02/2007
7259236	RBP1L1, a novel retinoblastoma binding protein-related gene encoding an antigenic epitope and methods of using thereof Disclosed herein is a novel retinoblastoma binding protein-related gene that encodes an antigenic epitope, IKPSLGSKK (SEQ ID NO:3), which is differentially expressed in cancers, such as breast, lung, colon, pancreas, and ovarian cancer. Polynucleotides that encode a...	08/21/2007
RE39760	Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/humans chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fr...	08/07/2007
7253263	Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of antibody against ganglioside GD3 The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to “GD3”), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and diagnosis of the antibody and the derivatives. ...	08/07/2007
7226750	Ovarian cancer cell and myeloma cell surface glycoproteins, antibodies thereto, and uses thereof The present invention is directed to cell surface antigenes found on myeloma cells and on ovarian cancer cells that are recognized by monoclonal antibodies, and antibody binding fragments thereof, as described. The monoclonal antibodies of the invention are capable ...	06/05/2007
7148038	Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treat...	12/12/2006
7118912	Methods and compositions for categorizing patients The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detec...	10/10/2006
7101979	Antibodies to antiangiogenic compositions and methods Antibody to endostatin protein that is an inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 18 kDa as determined by non-reduced gel electrophoresis, and approximately 20 kDa as determi...	09/05/2006
7074613	Monoclonal antibody directed against cells of human renal cell carcinoma The invention concerns a hybridome called 5C5 (CNCM no I-2184) and the monoclonal antibody 5C5 which it produces. Said monoclonal antibody which specifically recognises most human renal cell carcinomas, is developed for diagnosing, imaging and treating human renal c...	07/11/2006
7064188	Monoclonal antibodies which identify the glycoprotein carrying the CA125 epitope Hybridomally produced monoclonal antibodies specifically immunoreactive with the glycoprotein carrying the CA 125 epitope. Monoclonal antibodies recognize both high and low molecular weight subunits of the antigen, and identify the antigen in the cytoplasm and the e...	06/20/2006
7056702	Detecting lipocalin The invention provides antibodies reactive with distinct lipocalin epitopes that are useful for detecting inflammation and bacterial infections in mammals. ...	06/06/2006
7029866	Cancer diagnosis by the measurement of Nup88 in body samples The invention is directed to a method of diagnosis of the existence and/or the pathological developmental stage and/or the grade of malignancy of carcinomas and/or sarcomas in mammals characterized by the preparation of a body sample of said mammals and the determin...	04/18/2006
6955924	Laminin chains: diagnostic uses The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto. ...	10/18/2005
6872568	Death domain containing receptor 5 antibodies The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding...	03/29/2005
6855508	ELISA for VEGF The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA method and kits for VEG...	02/15/2005
6843990	Monoclonal antibodies for the detection of decoy receptor 3, hybridomas producing said antibodies and uses thereof The invention provides monoclonal antibodies against decoy receptor 3 (DcR3), hybridomas producing said antibodies, kits containing said monoclonal antibodies and uses of the hybridomas, antibodies and kits for the detection of DcR3-associated diseases, as well as f...	01/18/2005
6825324	Antibodies to receptor protein tyrosine kinases The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein...	11/30/2004
6693176	Antitumor antibodies, proteins, and uses thereof Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies....	02/17/2004
6689607	Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding human TR11, TR11SV1, and TR11SV2 receptors. TR11, TR11SV1, and TR11SV2 polypeptides are also p...	02/10/2004
6670466	Human endogenous retrovirus in breast cancer The present invention is related to mammary tumor virus (MTV). MTV represents a group of retroviruses which possess very high homology to mouse mammary tumor virus (MMTV), a virus known to cause neoplastic mammary disease in mice. As described herein, MTV...	12/30/2003
6632620	Compositions for identification and isolation of stem cells The invention provides monoclonal antibodies that selectively bind to ectodermally- and endodermally-derived stem cells and methods for the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Also discl...	10/14/2003
6617434	Identificiaton of differentially methylated and mutated nucleic acids The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and the methylation patterns of nucleic acids. Regions of the genome are differentially methylated or mutated in differe...	09/09/2003
6613538	Detection of HLA-G The present invention relates to the detection of HLA-G. Antibodies to both soluble and membrane bound HLA-G are disclosed. Exemplary antibodies include 2C/C8, 3C/G4, and 4H84. 2C/C8 and 4H84 antibodies bind to the same region of HLA-G, which is a differe...	09/02/2003
6573096	Compositions and methods for inhibition of cancer invasion and angiogenesis The invention provides antibodies to a membrane protease complex, consisting of two homodimers of seprase and dipeptidyl peptidase IV (DPPIV), obtained from human cell membranes. The antibodies specifically bind the DPPIV protease of the seprase-DPPIV com...	06/03/2003
6475775	PARG, a GTPase activating protein which interacts with PTPL1 The invention describes nucleic acids encoding the PARG protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods...	11/05/2002
6458356	Antibody-induced apoptosis Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to "tag" Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, me...	10/01/2002
6447776	Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the detection and for the therapy of diffuse gastric carcinom...	09/10/2002
6440733	Monoclonal antibodies recognizing antigens on the surface of endothelial cells of tumor vessel A monoclonal antibody which recognizes an antigen of a molecular weight of 40 kD or 80 kD on the surface of tumor vessel endothelial cells, hybridomas producing said monoclonal antibody, pharmaceutical agents comprising said monoclonal antibody, as well a...	08/27/2002

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Class 435/330 - Immunoglobulin or antibody binds an expression product of a cancer related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)