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| Number | Title | Issue Date |
| 8026080 | Real time electronic cell sensing system and applications for cell-based assays The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, ... | 09/27/2011 |
| 7374906 | Biological assays using gradients formed in microfluidic systems The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed ... | 05/20/2008 |
| 7364899 | Device for monitoring haptotaxis The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first well configured to receive a test agent therein and further including b... | 04/29/2008 |
| 7364874 | Mediucm for detecting Van A and Van B vancomycin-resistant entercocci and method of using the same Van A and Van B vancomycin resistant enterococci detection media as well as a method of selectively detecting Van A and Van B vancomycin resistant enterococci clinically important in vancomycin resistant enterococci from testing microorganisms o... | 04/29/2008 |
| 7314070 | Method and apparatus for gradient generation A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess differ... | 01/01/2008 |
| 7312046 | Method of screening compounds using a nanoporous silicon support containing macrowells for cells A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrient... | 12/25/2007 |
| 7297531 | Apparatus and method for testing liquid samples An article for holding a liquefied sample for the quantification of biological material in the sample includes a device having a reaction chamber enclosing a volume therein, the reaction chamber having an upper opening through which a liquefied sample can be poured ... | 11/20/2007 |
| 7270996 | Automated bioculture and bioculture experiments system The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, ase... | 09/18/2007 |
| 7262021 | Method for antimicrobial susceptibility testing of microorganisms Media, kits, and methods are disclosed for use in processes requiring microbial culture. More specifically, the invention provides carrageenan-stabilized agar-based microbial culture media for kits and methods. The media and kits of the invention possess increased s... | 08/28/2007 |
| 7186548 | Cell culture tool and method A cell co-culture tool includes a body, an outer wall surrounding the body, and more than one vessel within the perimeter of the outer wall. Each vessel has a top edge below a rim of the outer wall. A method of interacting a substance with more than one type ... | 03/06/2007 |
| 7186565 | Sampling and toxicity monitoring device and method A method and apparatus for testing an aqueous or gaseous environment for the presence of at least one chemical is provided in order to determine the toxicity of the chemical and optionally, the quantity and identity of the chemical. ... | 03/06/2007 |
| 7172859 | System and method for optimizing tissue barrier transfer of compounds The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal tra... | 02/06/2007 |
| 7138270 | Assay device and method for chemical or biological screening An assay device (1) comprises a base (2) and glass plate lid (3). The base (2) has an array of shallow microwells (4), each having a flat rim (9), all rims being co-planar. When the lid (3) is placed on the base (2... | 11/21/2006 |
| 7122338 | Method for quantification of biological material in a sample Methods for the detection and/or quantification of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation vessel. The incubation vessel has a generally flat horizo... | 10/17/2006 |
| 7115231 | Parallel reactor with knife-edge seal An apparatus for use in parallel reaction of materials. The apparatus includes a base having a plurality of reaction wells formed therein and a sealing device positioned over the reaction wells for individually sealing each of the reaction wells. One of the sealing ... | 10/03/2006 |
| 7106889 | Image analysis systems and devices for use therewith An image analysis system for automated reading of printed multi-character codes, for example on antibiotic susceptibility testing disks, makes use of an orientation means, for example an underline printed beneath the code, to bring the code or its image into canonic... | 09/12/2006 |
| 7033474 | Microfluidic devices incorporating improved channel geometries The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throu... | 04/25/2006 |
| 7026137 | Hepatitis A screening method of identifying a compound for treating hepatitis. Also disclosed is a method for evaluating responsiveness of a subject having hepatitis to a drug. ... | 04/11/2006 |
| 7011939 | Apparatus and method for electrophysiological testing A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test subjects, such as, for example, Xenopus oocytes. The invention furthe... | 03/14/2006 |
| 7005109 | System for handling liquid samples A system for handling liquid samples, comprising at least two superposed and interconnected planar elements between which a well for a liquid sample is formed which extends between an outwardly leading mouth to receive and/or deliver a liquid sample and an outwardly... | 02/28/2006 |
| 7005029 | Method of making a multi-well test plate having adhesively secured transparent bottom panel A method of making a multi-well test plate including an upper frame portion and a glass panel secured to a lower side of the upper frame portion with a layer of light-curable adhesive. The upper frame portion includes a plurality of walls defining adjacent wells for... | 02/28/2006 |
| 7000785 | Tube rack accommodating a range of tube diameters A tube rack for holding and transporting sample tubes or other liquids in an automated analyzer is built to accommodate tubes of different sizes in a stable aligned configuration, the rack containing a row of parallel open-top tube chambers, each chamber containing ... | 02/21/2006 |
| 6972184 | Cell motility assay An electrooptical method is disclosed for quantifying the motility response of cells to external stimuli, wherein a target cell population (formed as a function of said response) is subsequently optically differentiated by the addition of an optical differentiation ... | 12/06/2005 |
| 6958221 | Cell flow apparatus and method for real-time measurements of patient cellular responses The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents. ... | 10/25/2005 |
| 6908760 | Raised surface assay plate The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in-situ experimenta... | 06/21/2005 |
| 6872545 | Microbiological analyzer using colorimetric means for biochemical color and growth determinations A microbiological analyzer for performing ID tests on samples using colorimetric techniques to generate a pixel-wise colored map of a test region of interest and also performing MIC tests on samples using nephelometric techniques to determine which antimicrobial age... | 03/29/2005 |
| 6852526 | Transdermal assay with magnetic clamp The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a ... | 02/08/2005 |
| 6670145 | Method for detection of total coliforms and E. coli An improved method for detection of total coliforms and E. coli comprising a broth containing an ingredient that will encourage growth and repair of injured coliforms, buffers to maintain a pH in the range of 6.5-8, at least one agent that suppresses grow... | 12/30/2003 |
| 6649365 | Indolamine derivatives for detecting peptidase activity in culture media Compounds of formula X--NH--R, in which X represents an optionally substituted indol-3-yl group and R represents the acyl residue of an amino acid or of a peptide, enabling the detection of peptidase activity in a micro-organism culture medium, including ... | 11/18/2003 |
| 6632656 | Microfabricated apparatus for cell based assays Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an ... | 10/14/2003 |
| 6627432 | Liquid flow and control in a biological test array A microbiological test array with a generally flat base having a plurality of upwardly projecting microwells connected by a microchannel to an open reservoir formed in a top surface generally parallel to the base of the test array. The reservoir has an op... | 09/30/2003 |
| 6611765 | System for validation and interpreting results of antimicrobial susceptibility tests of micro-organisms The invention concerns a method for analyzing results of antimicrobial susceptibility tests of micro-organisms, the test consisting in summarily identifying which species the micro-organism belongs to and measuring the minimum inhibitory concentrations (C... | 08/26/2003 |
| 6485928 | Use of granulysin as an antimicrobial agent The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population. Of particular interest is the use of the active fragment ... | 11/26/2002 |
| 6365368 | Rapid method for the detection and quantification of microbes in water The present invention concerns methods of testing water for microbe contamination. The methods of the invention comprise supplementing existing methods with assays using specific reagents such as monoclonal antibodies. The invention also concerns a device... | 04/02/2002 |
| 6309889 | Nano-grid micro reactor and methods The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface, and a plurality of holding locations that are adapted to ho... | 10/30/2001 |
| 6284526 | Method and apparatus for determining the sensitivity of a microorganism to a growth altering agent A method and an apparatus for determining the concentration at which a growth-altering agent has an appreciable effect on the growth of a target microorganism are provided. The method comprises the steps of (a) providing a microorganism growth medium; (b)... | 09/04/2001 |
| 6265229 | Method and device for detection of specific target cells in specialized or mixed cell populations and solutions containing mixed cell populations The invention relates to a method and apparatus for detecting specific target cells in a simple and time-saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating ant... | 07/24/2001 |
| 6235541 | Patterning antibodies on a surface Substrates are patterned with antibodies attached thereto at discrete locations from which absorption resistant coating is removed by selectively controlled mechanical scribing contact to avoid chemical removal so as to decrease fabrication costs and incr... | 05/22/2001 |
| 6225079 | Microtitration unit A microtitration unit being at least one container of transparent material for accommodating biological test reaction mixtures. The container is subdivided into at least two chambers suitable for accommodating different test reaction mixtures by at least ... | 05/01/2001 |
| 6197575 | Vascularized perfused microtissue/micro-organ arrays Systems including (1) a micromatrix and perfusion assembly suitable for seeding and attachment of cells within the matrix and for morphogenesis of seeded cells into complex, hierarchical tissue or organ structures, wherein the matrix includes channels or ... | 03/06/2001 |
