Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8187873 | Monoclonal antibody to soluble LOX-1 It is intended to provide a monoclonal antibody that specifically recognizes human soluble LOX-1, particularly a monoclonal antibody with a dissociation constant (Kd) for human soluble LOX-1 of 1×10−9 (M) or less. The antibody can be produced from a hy... | 05/29/2012 |
| 8173424 | Internalizing ErbB2 antibodies This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F... | 05/08/2012 |
| 8168427 | Monoclonal antibodies against claudin-18 for treatment of cancer The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cance... | 05/01/2012 |
| 8163551 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation. ... | 04/24/2012 |
| 8143056 | Vascular adhesion molecules and modulation of their function The invention relates to new polypeptides in isolated form belonging to a subfamily of the human immunoglobulin superfamily, which polypeptide shows at least 70% sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 o... | 03/27/2012 |
| 8071371 | Monoclonal antibody production by EBV transformation of B cells A method for producing a clone of an immortalized human B memory lymphocyte, comprising the step of transforming human B memory lymphocytes using Epstein Barr Virus (EBV) in the presence of a polyclonal B cell activator. The method is particularly useful in a method... | 12/06/2011 |
| 8003385 | In vitro germinal centers The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and ot... | 08/23/2011 |
| 7998738 | Integrin-binding antibodies Ligand-mimetic monoclonal antibody mAb 107, produced by a hybridoma cell line deposited in the American Type Culture Collection under Accession Number ATCC PTA-11614, which binds to CD11b MIDAS in an activation-independent manner. ... | 08/16/2011 |
| 7981672 | Monoclonal antibody and use thereof The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid... | 07/19/2011 |
| 7977093 | Obtention of food- or auto-antigen specific TR1 cells from a leukocyte or PBMC population An in vitro method for the obtention of a food- or auto-antigen specific Tr1 cell population from a leukocyte or a PBMC population, includes stimulating the PBMC or leukocyte population with the food- or auto-antigen, and recovering the food- or auto-antigen specifi... | 07/12/2011 |
| 7972846 | Cadherin-11 antagonists and methods for the treatment of inflammatory joint disorders The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumatoid arthritis, in a mammalian subject by administering a the... | 07/05/2011 |
| 7972845 | Human antibodies against LPS derived from transgenic xenomouse The invention described herein provides for human antibodies produced in non-human animals that specifically bind to Pseudomonas aeruginosa Lipopolysaccharide (LPS). The invention further provides methods for making the antibodies in a non-human animal, expre... | 07/05/2011 |
| 7960174 | Hybridoma producing antibodies to The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 06/14/2011 |
| 7951589 | Monoclonal antibodies specific for the chemotactic epitope of the urokinase-type plasminogen activator receptor The present invention describes monoclonal antibodies specific for the chemotactic epitope of the uPAR. In particular, the invention comprises monoclonal antibodies against uPAR fragments specifically recognizing in whole or in part the chemotactic sequence of uPAR ... | 05/31/2011 |
| 7935528 | Liver stem cell The invention provides a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantat... | 05/03/2011 |
| 7846724 | Method for selecting CHO cell for production of glycosylated antibodies The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition ... | 12/07/2010 |
| 7846725 | Antibody composition-producing cell in which enzyme expression is inhibited by RNAi The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 12/07/2010 |
| 7833786 | Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani... | 11/16/2010 |
| 7824912 | Methods for ex vivo propagation of adult hepatic stem cells The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kin... | 11/02/2010 |
| 7811816 | Isolated CD8 T lymphocytes specifically cytotoxic for a disease causing target cell Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 10/12/2010 |
| 7785881 | MAGE-C2 antigenic peptides and uses thereof This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucl... | 08/31/2010 |
| 7741115 | Antibodies that bind LDCAM The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides. | 06/22/2010 |
| 7674619 | ADAM-9 modulators The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and t... | 03/09/2010 |
| 7651854 | Methods for increasing the proliferation of B cells Disclosed herein are methods of increasing the proliferation of non-tumorigenic B cells. The methods involve administering PCDGF and optionally other B cells stimulators (e.g., IgM, LPS) to B cells resulting in an increase in B cell proliferation. The methods of the... | 01/26/2010 |
| 7615372 | Antibodies with immune effector activity and that internalize in endosialin-positive cells This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing endosialin and to induce an immune effector activity such as antibody-dependent cel... | 11/10/2009 |
| 7611894 | Anti-idiotype antibodies of the human monoclonal antibody SC-1, and their production and use The invention features anti-idiotype antibodies of the human monoclonal antibody SC-1, as well as methods for producing and using the anti-idiotype antibodies. ... | 11/03/2009 |
| 7575922 | Polypeptide and gene encoding the same A polypeptide having the amino acid sequence as set forth in SEQ ID NO: 2, 4, or 6, a DNA encoding the same, and an antibody against said polypeptide, and the use thereof. The above amino acid sequence has a homology with chondromodulin-I that has an effect of contr... | 08/18/2009 |
| 7534605 | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: ... | 05/19/2009 |
| 7504254 | Methods for isolating molecular mimetics of unique serogroup B epitopes Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The ant... | 03/17/2009 |
| 7438911 | Antibody against human insulin-like growth factor For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present in... | 10/21/2008 |
| 7439037 | Use of aminoglycoside resistance gene Use of aminoglycoside resistance gene product for achieving high-density growth of animal cells. ... | 10/21/2008 |
| 7435585 | Auto-stimulating cells and methods for making and using the same Methods for transferring one or more proteins to a cell are disclosed. The protein or proteins to be transferred are in the form of a fusion protein, and contain at least one domain encoding for a protein or peptide having trans signaling and/or adhesion function. T... | 10/14/2008 |
| 7435871 | Transgenic animals bearing human Igλ light chain genes The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human λ light chain loci. The invention further relates to methods... | 10/14/2008 |
| 7432081 | disulfide bond formation proteins and uses thereof Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are... | 10/07/2008 |
| 7429486 | Recombinant production of mixtures of antibodies The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recomb... | 09/30/2008 |
| 7429487 | Fusion partner for production of monoclonal rabbit antibodies The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, ... | 09/30/2008 |
| 7427670 | Cytochrome P450 24 (CYP24) monoclonal antibody and methods and uses thereof This invention relates to a monoclonal antibody for CYP24 and to methods and uses therefore, such as in Western blot analysis, immunohistochemisty, protein purification; diagnostics, such as for cancer, vitamin D metabolic conditions and the like. ... | 09/23/2008 |
| 7427495 | Methods of using Bcl-2 for the therapeutic treatment and prevention of diseases The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the disease or pathological condition. Diseases or pathological conditions ca... | 09/23/2008 |
| 7427669 | ULBP antibodies The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived... | 09/23/2008 |
| 7425446 | Antibody composition-producing cell The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region o... | 09/16/2008 |
