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| Number | Title | Issue Date |
| 8183039 | Method for isolating BDCA-4+ dendritic cells The application describes, inter alia, a method for isolating or enriching for dendritic cells from a mixture of human cells involving contacting cells in the mixture with an antibody that binds BDCA-4, or antigen-binding fragment thereof, under conditions in which ... | 05/22/2012 |
| 8178347 | Gene regulatory networks and methods of interdiction for controlling the differentiation state of a cell The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor ... | 05/15/2012 |
| 8173423 | Diagnosis and treatment of T-cell acute lymphoblastic leukemia The present invention relates to the field of biotechnological means to diagnose or treat T-cell acute lymphoblastic leukaemia. More particularly, the invention relates to methods to diagnose T-cell acute lymphoblastic leukaemia via determining the presence of a dup... | 05/08/2012 |
| 8168426 | Multiple inducible gene regulation system The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of m... | 05/01/2012 |
| 8163549 | Method of obtaining viable small tissue particles and use for tissue repair The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extra... | 04/24/2012 |
| 8163550 | Enhancement of immune responses by 4-1BB-binding agents This invention features methods of enhancing immune responses in mammalian subjects and in vitro methods of enhancing the response of a T cell. Also embodied by the invention are methods of receiving and preventing the induction of energy in T cells. ... | 04/24/2012 |
| 8158593 | GPR17 modulators, method of screening and uses thereof The invention provides GPR17 modulators, methods of screening and use thereof for diagnosis and therapy of diseases or dysfunctions involving GPR17 activation, particularly ischemic brain damage. ... | 04/17/2012 |
| 8158417 | Recombinant cell lines for the stable and high-level production of biologically active Dkk1 protein This invention relates to the use of specific recombinant cell lines in order to produce biologically active DKK1 protein in a stable and high-level manner. The invention also relates to these recombinant cell lines, as well as a method for stable and high-level pro... | 04/17/2012 |
| 8158418 | Chimeric alphavirus replicon particles Chimeric alphaviruses and alphavirus replicon particles are provided, including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/... | 04/17/2012 |
| 8153422 | Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases Disclosed herein are methods for generating dopaminergic neurons in vitro by inhibiting a pathway component of a TGF-β signaling pathway and overexpressing one or more cell fate-inducing polypeptides in pluripotent cells, causing differentiation of the pluripotent ... | 04/10/2012 |
| 8153421 | Prostate stem cell We describe a method for the isolation of prostate stem cells, typically prostate stem cells which express CD 133 antigen; stem cells and cancer stem cells isolated by the method and their use. ... | 04/10/2012 |
| 8148146 | Cell line The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes. ... | 04/03/2012 |
| 8143055 | Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bo... | 03/27/2012 |
| 8137965 | Methods and compositions for tissue regeneration A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vial, and a second component comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more b... | 03/20/2012 |
| 8137964 | Method of producing three-dimensional tissue and method of producing extracellular matrix used in the same The present invention provides a novel method of producing a three-dimensional tissue by which cell lamination can be carried out easily. According to the method, a three-dimensional tissue in which cell layers are laminated with an extracellular matrix intervening ... | 03/20/2012 |
| 8133725 | Bone marrow stromal cells comprising a nucleic acid encoding a notch intracellular domain There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to ne... | 03/13/2012 |
| 8133724 | Human androgen receptor alternative splice variants as biomarkers and therapeutic targets The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and ... | 03/13/2012 |
| 8129182 | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell pop... | 03/06/2012 |
| 8129183 | Method for stimulating dendritic cells and cell product thus obtained for the autologous immunotherapy of solid human tumours In the ex vivo stimulation method of dendritic cells, the stimulation occurs with the lysate of tumor spheres (TS) of the solid tumors. ... | 03/06/2012 |
| 8124408 | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated... | 02/28/2012 |
| 8119399 | Method and system for collecting cells of a biological specimen A method for determining when sufficient cells of a biological specimen have been collected by a filter is based on measuring an air flow rate between a filter and a vacuum source. The air flow rate can be measured by a mass air flow sensor. The air flow rate droppi... | 02/21/2012 |
| 8119397 | Therapeutic agents and therapeutic methods for treating injured tissue This invention provides therapeutic agents, transplants and therapeutic methods that can enhance the regeneration of injured tissue. This invention relates to agents, transplants and therapeutic methods for enhancing the migration and accumulation of mesenchymal ste... | 02/21/2012 |
| 8119400 | Methods of inhibiting smooth muscle cell migration and proliferation In particular embodiments, the present invention provides methods of inhibiting smooth muscle cell responses and methods of treating or preventing vascular proliferative disease caused by smooth muscle cell migration and proliferation. More specifically, smooth musc... | 02/21/2012 |
| 8119398 | Adipose-derived stem cells for tissue regeneration and wound healing Compositions and methods for promoting tissue regeneration, particularly skin regeneration, with adipose-derived stem cells are provided. Additionally methods and compositions for promoting tissue regeneration with adipose-derived stem cell side population cells are... | 02/21/2012 |
| 8110398 | Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals an... | 02/07/2012 |
| 8110354 | Use of invaplex to transport functional proteins and transcriptionally active nucleic acids across mammalian cell membranes in vitro and in vivo The in vivo and in vitro use of Invaplex to transport materials, including functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. The eukaryotic cells include a variety of cell types, e.g. insect, reptile, fish, mammal and tumor... | 02/07/2012 |
| 8105827 | Protein expression systems Disclosed are recombinant non-insect host cells and use of activation of CMV or SV40 promoters by IE1, IE2 and the enhancer hr of the baculovirus in non-insect host cells for expression heterologous RNAs or polypeptides. Also disclosed are methods of using the cells... | 01/31/2012 |
| 8105826 | Nucleotide and amino acid sequences relating to respiratory diseases and obesity This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide seque... | 01/31/2012 |
| 8105828 | Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals an... | 01/31/2012 |
| 8105829 | Fluorometric analysis kit Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-... | 01/31/2012 |
| 8105825 | Multiple inducible gene regulation system The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of m... | 01/31/2012 |
| 8101407 | Stem cells, nucleotide sequences and proteins therefrom The present invention provides novel stem cells, nucleotide sequences and proteins therefrom. More specifically, the present invention provides Pax7+/Myf5− stem cells and methods for identifying and isolating them. Also provided is a MEGF10 nucleotide sequence and... | 01/24/2012 |
| 8097454 | Model system for identifying anti-cancer agents A model system for screening and identification of compounds that interfere with Gli2 dependent tumorigenesis and provide potential use as anticancer agents is provided. In particular, the invention includes a Gli2 protein having an S662A point mutation that interfe... | 01/17/2012 |
| 8097455 | System and method for forming skeletal muscle constructs having functional tissue interfaces A system and method for forming a skeletal muscle construct include primary muscle cells provided on a substrate without disposing the cells within an exogenous scaffold, the cells cultured in vitro such that the cells form a confluent monolayer; at least two anchor... | 01/17/2012 |
| 8093043 | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis The invention relates to modulating BimEL levels (Bcl-2-Interacting Mediator of cell death, Extra Long isoform) to sensitize cancer cells to cell death or apoptosis. In certain embodiments, the invention relates to increasing BimEL levels. In certain embodiments, th... | 01/10/2012 |
| 8093225 | Gene expression and pain The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate nociceptive signaling in a cell or prevent and/or treat pain in a pat... | 01/10/2012 |
| 8093044 | Methods for identifying inhibitors of botulinum neurotoxins A system and method for identifying a botulinum neurotoxin inhibitor employing a botulinum neurotoxin substrate complex having a peptide substrate, preferably SNAP-25, a reporter domain on one side of said peptide substrate and an immobilization domain on the opposi... | 01/10/2012 |
| 8084251 | Recombinant cell clones having increased stability and methods of making and using the same Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recom... | 12/27/2011 |
| 8084253 | Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 12/27/2011 |
| 8084252 | Recombinant cell clones having increased stability and methods of making and using the same Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recom... | 12/27/2011 |
