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| Number | Title | Issue Date |
| 8187872 | Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant;... | 05/29/2012 |
| 8187871 | Co-crystallization of ERR-α with a ligand that forms a reversible covalent bond The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands tha... | 05/29/2012 |
| 8187870 | Means for obtaining avirulent promastigotes, promastigotes obtained, and the applications thereof The invention relates to an expression vector of a gene coding for an antigenic protein of Leishmania promastigote, characterized in that it comprises a PSA gene insert in opposite orientation. The invention can be applied to the development of mutants under-... | 05/29/2012 |
| 8182987 | Probe for visualizing cell-cycle An object of an embodiment of the present invention is to provide a method with which it is possible to easily distinguish a proliferation phase of a cell cycle from a resting phase thereof in real time. The object of the embodiment of the present invention is attai... | 05/22/2012 |
| 8183038 | Composition comprising recombinant nucleic acid encoding Sox2, Oct-4, Nanog and Lin28 The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a r... | 05/22/2012 |
| 8183036 | Luciferase biosensor A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided. ... | 05/22/2012 |
| 8183037 | Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs This disclosure concerns compositions and methods for genetically encoding and expressing prokaryotic tRNAs in eukaryotic cells. In some embodiments, the disclosure concerns methods and compositions for expressing unnatural amino acids in eukaryotic cells using orth... | 05/22/2012 |
| 8178346 | GPCR expression vector The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines expressing GPCR proteins with the aid of the expression vectors of the ... | 05/15/2012 |
| 8173422 | Method for improving protein production The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at leas... | 05/08/2012 |
| 8173613 | Modulation of mesenchymal and metastatic cell growth The present invention relates to compositions and methods for the modulation of metastatic and mesenchymal cell growth and mobility via the regulation of the formation of Twist/Twist homodimers and Twist/E heterodimers. The present invention also relates to methods ... | 05/08/2012 |
| 8168425 | Expression of factor IX in gene therapy vectors Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions mi... | 05/01/2012 |
| 8168593 | Mutated netrin-4, fragments thereof and their use as medicines A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the proliferation and migration of pericytes and smooth muscle cells. Ph... | 05/01/2012 |
| 8163542 | Potent combinations of mRNA transport elements This invention provides expression vectors that comprise a combination of RNA transport elements that improve expression. ... | 04/24/2012 |
| 8163546 | Mammalian cell-based immunoglobulin display libraries Disclosed are mammalian cell surface display vectors for isolating and/or characterizing immunoglobulins and various uses thereof. ... | 04/24/2012 |
| 8163545 | Vaccine against pandemic strains of influenza viruses The present disclosure provides compositions and methods for eliciting an immune response against avian or pandemic influenza. The compositions include adenovirus vectors comprising avian influenza antigens, recombinant adenovirus and immunogenic compositions compri... | 04/24/2012 |
| 8163548 | Recombinant bicistronic flaviviruses and methods of use thereof The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5′ to 3′, a viral 5′UTR, an ORF encoding all viral proteins, an internal ribosome entry site, an... | 04/24/2012 |
| 8163547 | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and pept... | 04/24/2012 |
| 8163543 | AAV vectors produced in insect cells The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation... | 04/24/2012 |
| 8163544 | Methods and compositions for increasing tissue tropism of recombinant adenoviral vectors Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided. ... | 04/24/2012 |
| 8158413 | Lentiviral vector-based vaccine Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed. ... | 04/17/2012 |
| 8158414 | Gene silencing The present invention relates to unique strategies and constructs for producing a nucleic acid product that down-regulates or prevents expression of a desired target polynucleotide. Such construct may include an expressing cassette having two convergently-oriented p... | 04/17/2012 |
| 8158415 | Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct... | 04/17/2012 |
| 8158416 | CDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids ... | 04/17/2012 |
| 8153420 | Polynucleotides encoding stop codons in multiple reading frames and methods of use Compositions having polynucleotides encoding multiple translational stop signals in more than one reading frame are provided. The compositions include isolated polynucleotides, expression cassettes, and vectors, as well as host cells, prokaryotic organisms, and euka... | 04/10/2012 |
| 8148144 | pCryptoRNAi A vector developed to transform fungi can be used to study the expression of a gene of interest. The vector can provide for the expression of signal proteins in fungi that can be observed and/or monitored. The vector can be used to investigate the effects of RNA int... | 04/03/2012 |
| 8148302 | In situ assembling of protein microarrays The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protei... | 04/03/2012 |
| 8148145 | Virus coat protein variants with self-subtracting properties Herein is described a modified viral vector comprising: a coat protein modified, for example by the addition of a cysteine residue, such that the modified viral vector yields less soluble virus relative to that from an unmodified viral vector upon extraction of plan... | 04/03/2012 |
| 8148143 | Method and composition for genetically modifying non-human cells and animals A vector and its use to generate genetically modified animals and cells is disclosed. One aspect involves a vector that comprises a sperm cell and one or more polynucleotide molecules bound to a sperm cell through one or more anti-sperm antibody linker. In one prefe... | 04/03/2012 |
| 8148334 | Peptides with capacity for binding with interleukine 10 (IL-10) The invention relates to peptides having the capacity to bind to interleukin-10 (IL-10) and their use in the treatment of clinical conditions or pathological disorders associated to IL-10 expression, particularly to a high IL-10 expression, for example, infectious d... | 04/03/2012 |
| 8143054 | Fusion protein of HIV regulatory/accessory proteins The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processe... | 03/27/2012 |
| 8143005 | Nucleic acids encoding sodium channel SCN1A alpha subunit proteins and mutations associated with epilepsy The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome 2, which show mutations in patients with epilepsy. The invention furth... | 03/27/2012 |
| 8137960 | Bovine adeno-associated viral (BAAV) vector and uses thereof The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles. ... | 03/20/2012 |
| 8137961 | Plant-specific genetic elements and transfer cassettes for plant transformation The present invention provides nucleic acid molecules and sequences, particularly those identified and obtained from plants, that are useful for transferring and integrating one polynucleotide into another via plant transformation techniques. ... | 03/20/2012 |
| 8137962 | Compositions for treating cystic fibrosis The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic fibrosis patients. ... | 03/20/2012 |
| 8137963 | Method for highly amplifying target gene in mammalian cell and vector therefor A vector of the present invention is a vector for amplifying a target gene in a mammalian cell, the vector including an amplification-activating fragment, which is a partial fragment of a mammalian replication initiation region and has a gene amplification activity ... | 03/20/2012 |
| 8133723 | Vaccines against multiple subtypes of influenza virus An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is... | 03/13/2012 |
| 8129181 | F1B-TMIR plasmid vector and transgenic mouse A trifusion reporter plasmid is described that comprises a plasmid operably coupled to a mammalian FGF1B promoter that is operably coupled to a bioluminescence gene fused to a fluorescence gene fused to a nuclear medical imaging gene. The new reporter allows in vivo... | 03/06/2012 |
| 8129180 | Protein exhibiting activity of pyrethrin biosynthetic enzyme, gene encoding the protein, and vector bearing the gene The present invention relates to an enzyme determining amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing ... | 03/06/2012 |
| 8124404 | Stable integrands There is provided a transposable element comprising at least four inverted repeats, at least two of which are each inverted in relation to another, the element comprising DNA for insertion into a host genome, the DNA being located between two pairs of opposing repea... | 02/28/2012 |
| 8124407 | Circular nucleic acid vectors, and methods for making and using the same Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the sub... | 02/28/2012 |
