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| Number | Title | Issue Date |
| 8110375 | High throughput assay for cancer cell growth inhibition A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media transfected with the subject compound, and enables live colony growth determi... | 02/07/2012 |
| 8034580 | Determining presence of antibiotic in a fluid The pressure of an antibiotic in a fluid is determined by contacting a sample of the fluid suspected of containing an antibiotic with a test medium containing a microorganism, a substance that provides a solid state and an indicator, such as Bromothymol Blue, incuba... | 10/11/2011 |
| 8012711 | Methods of screening for compounds that reduce microbial resistance to fluoroquinolones The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of sc... | 09/06/2011 |
| 7955817 | Vaccine protection assay The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningoc... | 06/07/2011 |
| 7932051 | Blood and urine test The present invention provides a test medium comprising a test microorganism, an indicator and a metal in ionized form, wherein the valence of said metal is at least 2 and the concentration of said metal is between 0.001 M and 1 M. Furthermore, there is provided a m... | 04/26/2011 |
| 7901903 | Determining presence of antibiotic in a fluid The pressure of an antibiotic in a fluid is determined by contacting a sample of the fluid suspected of containing an antibiotic with a test medium containing a microorganism, a substance that provides a solid state and an indicator, such as Bromothymol Blue, incuba... | 03/08/2011 |
| 7897365 | Method for adjusting antibiotic sensitivity of a test culture The present invention relates to a method for adjusting the sensitivity of a microbial culture to an antibiotic. The method employs a substance derived from a bacterial species with sensitivity to the antibiotic. Such bacterial species include the same species used ... | 03/01/2011 |
| 7892782 | Screening process for antibacterial agents The present invention relates to a method of preparing a phenotypically antibiotic-resistant subpopulation of stationary phase bacteria by treating stationary phase bacteria with high doses of antibacterial agents, the subpopulation thus identified, a process for id... | 02/22/2011 |
| 7879576 | Marine actinomycete taxon for drug and fermentation product discovery The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus ... | 02/01/2011 |
| 7871790 | Anthrax bioassays and methods of treating and diagnosing anthrax infection Based on the observation that exposure of cells or animals to anthrax lethal toxin results in activation of the intracellular enzyme caspase-1/IL-1 converting enzyme (ICE), which, in turn, leads to production and extracellular release of the cytokine substrates of I... | 01/18/2011 |
| 7829305 | Method for monitoring the presence of biofilmforming microorganisms in paper industry The invention is directed to a method for detecting the presence of biofilm-forming microorganisms in a paper or board making process for determining the need of an anti-biofilm agent in the process. The method comprises the steps: (a) subjecting a sampler device in... | 11/09/2010 |
| 7824882 | Oligosaccharides in a test system for the determination of the presence of an antibiotic in a fluid Provided is a test system, a test method and a test kit for the determination of the presence of an antibiotic in a fluid based on a test medium comprising a test organism, at least one substance that provides a solid state, nutrients and an indicator, wherein the e... | 11/02/2010 |
| 7794967 | Method and kit for detection of novel pathogen inhibitors The present invention relates to a method for detection of novel pathogen inhibitors using models of pathogen specific, and metal binding structures/domains representing essential cellular molecules. The method enables identification of inhibitors that bind to any s... | 09/14/2010 |
| 7781186 | Screening methods using normal human liver cell line In this application is described the establishment and maintenance of a normal human hepatocyte cell line able to support complete development of malaria parasite development in vitro. The cell line can be used in methods for screening compounds affecting normal hum... | 08/24/2010 |
| 7666619 | Compounds and methods for regulating bacterial growth and pathogenesis The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis. ... | 02/23/2010 |
| 7648830 | Method for determining the presence of bacteria resistant to cell lysing antibiotics A method is provided for determining the presence of a target bacteria based on its resistance to a cell lysing antibiotic. Said antibiotic is used to lyse cells of non-target bacteria in a sample and hence facilitate isolation of the target prior to detection by kn... | 01/19/2010 |
| 7642068 | Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable ba... | 01/05/2010 |
| 7629141 | Essential and important genes of and the use thereof to design or identify antibacterial agents The invention includes a database of candidate essential genes in Pseudomonas aeruginosa, as well as other important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacter... | 12/08/2009 |
| 7625719 | Microsample treatment apparatus A method of using a microsample treatment apparatus and an apparatus for detecting chemotaxis of cells and separating chemotactic cells includes a number of wells that are connected to each other via a part having resistance to fluids. The wells are each provided wi... | 12/01/2009 |
| 7622275 | Aequorin as a growth marker in yeast A yeast cell containing constitutively expressed aequorin and methods of using the cells in growth and toxicity assays are disclosed. ... | 11/24/2009 |
| 7601512 | Methods for identifying inhibitors of the 20S and 26S proteasome The present invention relates to methods for identifying fungicides and also inhibitors of the 20S and 26S proteasomes, to methods for isolating 20S proteasomes, to the use of 20S proteasomes for identifying fungicides and to the use of the inhibitors of 26S and/or ... | 10/13/2009 |
| 7592154 | Modulating SOS response induction by antimicrobial agents Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiti... | 09/22/2009 |
| 7588912 | Compositions and methods for preventing and treating anthrax diseases Compounds, methods for identifying compounds and methods for using compounds which modulate interaction of lethal factor and anthrolysin O in the treatment and prevention of anthrax diseases are provided. ... | 09/15/2009 |
| 7575889 | Compound combinations for inhibiting cell division and methods for their identification and use The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compoun... | 08/18/2009 |
| 7537913 | High throughput assay for cancer cell growth inhibition A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media transfected with the subject compound, and enables live colony growth determi... | 05/26/2009 |
| 7517666 | Methods of inhibiting This application relates to methods of screening molecules capable of inhibiting the survival of Helicobacter pylori in vivo by specifically inhibiting the activity of UreI, to the molecules identified by these methods, and to the use of these molecules to tr... | 04/14/2009 |
| 7465559 | Method for calibrating antibiotic disk diffusion testing of microorganisms A method for calibrating antimicrobic susceptibility testings of microorganisms comprises the steps of creating a histogram with a high response side and a low response side of isolates from a microbial species, which may contain resistant strains against an antimic... | 12/16/2008 |
| 7462464 | Method for the detection of antimicrobial residues in food and bodily fluid samples The present invention relates to a novel method for the rapid detection of the presence or absence of antimicrobial residues in products preferably food products. ... | 12/09/2008 |
| 7435538 | High throughput screening method of drug for physiologically active protein The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use of a wheat embryo extract solution. The present inventors have stren... | 10/14/2008 |
| 7425411 | Method for recovering microorganisms from a sample The present invention provides for a method for recovering microorganisms from a sample that is rapid and provides microorganisms substantially free of adsorbents and other particles. The method includes mixing a sample comprising a medium, an adsorbent and microorg... | 09/16/2008 |
| 7416840 | Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection. ... | 08/26/2008 |
| 7390873 | Antimicrobial cationic peptides A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X1X1PX2X... | 06/24/2008 |
| 7378235 | Method for screening compounds against by using persistent virus-infected cell system This invention provides a method for screening compounds against Flavivirus. More specifically, this invention provides a method for screening compounds against Flaviviruses by using a persistent virus-infected cell system, including (a) establishment ... | 05/27/2008 |
| 7368232 | High-throughput assay for virus entry and drug screening The present invention provides a rapid virus entry/binding detection assay. An enzyme such as luciferase was incorporated at the C-terminal end of viral envelope proteins of the HIV Nef protein that would specifically associate with cell membranes to deliver the enz... | 05/06/2008 |
| 7369057 | Power generator and power generator auxiliary monitoring A generator monitoring system and method includes a plurality of sensors (12) disposed within a generator enclosure (18) to sense health conditions of a generator (10) housed within the enclosure. The sensors are interconnected to provide a sing... | 05/06/2008 |
| 7369471 | Method and system for fluid mediated disk activation and deactivation Embodiments of methods and systems for controlling access to information stored on memory or data storage devices are disclosed. In various embodiments, fluid-mediated modification of information or access to information is utilized. According to various embodiments... | 05/06/2008 |
| 7364874 | Mediucm for detecting Van A and Van B vancomycin-resistant entercocci and method of using the same Van A and Van B vancomycin resistant enterococci detection media as well as a method of selectively detecting Van A and Van B vancomycin resistant enterococci clinically important in vancomycin resistant enterococci from testing microorganisms o... | 04/29/2008 |
| 7364856 | PknB kinase and pstP phosphatase and methods of identifying inhibitory substances The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances. ... | 04/29/2008 |
| 7355033 | Screening for West Nile Virus antiviral therapy The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or replicon system engineered with one or more nucleotide sequences each ... | 04/08/2008 |
| 7354731 | Method of screening for potential anti-bacterial agents The invention provides a method of screening for potential anti-bacterial agents being antagonists of one or both of the transglycosylase and the transpeptidase enzymes involved in peptidoglycan biosynthesis in bacteria. The method is suitable for high throughput sc... | 04/08/2008 |
