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| Number | Title | Issue Date |
| 8008070 | Using coulomb forces to study charateristics of fluids and biological samples A LoC (Lab on a Chip) is described to analyze surface properties of fluid drops. Substrates with cavities near the edge are filled with fluids that have a contact angle greater than 90°. The surfaces of two different drops can be brought in contact with one another... | 08/30/2011 |
| 7955842 | Microfluidic device and method for concentrating sample containing cells or viruses and lysing cells or viruses, and method of producing the microfluidic device A microfluidic device for concentrating a sample including cells or viruses and lysing the cells or viruses, the device including an anode chamber including an anode electrode, a cathode chamber including a cathode electrode and an ion exchange membrane separating t... | 06/07/2011 |
| 7863040 | Ready-to-use whole blood collection vessel The present invention relates to a sampling tube for collecting and processing a whole blood sample. The sampling tube contains a reagent for differential hemolysis of whole blood, wherein said reagent for differential hemolysis comprises a chemical for differential... | 01/04/2011 |
| 7785869 | Sonication to selectively lyse different cell types A sonication apparatus is directed to a microfluidic-based system to automate differential extraction of specific cell types within a mixed sample. The microfluidic-based system includes a sonication module for selective cell lysis, separating means to eliminate cen... | 08/31/2010 |
| 7785868 | Apparatus to automatically lyse a sample A standalone bench top laboratory instrument designed to disrupt, or lyse, cells, spores and tissue samples using ultrasonic energy. The lysing device is programmable, allowing the user control over the sample volume, sonication power level, and lysing duration in o... | 08/31/2010 |
| 7491527 | Microfluidic differential extraction cartridge A differential extraction system is directed to a micro fluidic-based integrated cartridge to automate differential extraction of specific cell types within a mixed sample. The integrated cartridge includes a sonication module for selective cell lysis, separating me... | 02/17/2009 |
| 7488596 | Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between the anode chamber and the cathode chamber, the anode chamber includes a... | 02/10/2009 |
| 7419575 | Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rap... | 09/02/2008 |
| 7329388 | Electrophoresis apparatus having staggered passage configuration An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a ... | 02/12/2008 |
| 7329039 | Systems and methods for determining a state of fluidization and/or a state of mixing Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy. ... | 02/12/2008 |
| 7270284 | Tissue homogenizer A tissue homogenizer. The tissue homogenizer comprises a first chamber, a pair of blades, a first filter and a second filter. The first chamber has a first opening and a second opening. The blades are disposed in the first chamber. The first filter is disposed in th... | 09/18/2007 |
| 7244612 | Template reporter bacteriophage platform and multiple bacterial detection assays based thereon The invention is a method for the development of assays for the simultaneous detection of multiple bacteria. A bacteria of interest is selected. A host bacteria containing plasmid DNA from a T even bacteriophage that infects the bacteria of interest is infected with... | 07/17/2007 |
| 7238522 | Devices and methods for biomaterial production An apparatus and a method for isolating a biologic product, such as plasmid DNA, from cells. The method involves lysing cells in a controlled manner separate insoluble components from a fluid lysate containing cellular components of interest, followed by membrane ch... | 07/03/2007 |
| 7188994 | Orbital shaker for cell extraction A orbital shaker for cell extraction includes a digestion chamber and structure for translating the digestion chamber. Structure is also provided for rotating the digestion chamber. A method of performing cell extraction is also disclosed. ... | 03/13/2007 |
| 7176018 | Cell lysis device A micromachined cell lysis device with electrodes that are spaced by less than 10 μm from one another. The cells are attracted to the space between the electrodes and then lysed. ... | 02/13/2007 |
| 7056009 | Dispersing tool with an inner shaft rotatable within a hollow shaft to create a pumping effect A dispersing tool (1) is provided having a hollow shaft (2), which has an open, laterally slotted region on its free end (4) that faces away from a drive that is at the bottom in the position of use, and with an inner shaft (3), which can... | 06/06/2006 |
| 7033068 | Substrate processing apparatus for processing substrates using dense phase gas and sonic waves Embodiments of the invention are directed to substrate processing apparatuses and methods for processing substrates. In one embodiment, a substrate processing apparatus includes a processing chamber, a substrate holder inside of the processing chamber for holding a ... | 04/25/2006 |
| 6992181 | DNA isolation method Disclosed is a method and apparatus for the isolation of DNA or cell nuclei or a mixture thereof from cell samples in a CD device. The method includes treating a suspension of whole cells with a lysis reagent so as to lyse the cytoplasmic membrane and at least some ... | 01/31/2006 |
| 6987018 | Container for holding cells or viruses for disruption A container for holding cells or viruses for disruption comprises a chamber defined by two spaced apart, opposing major walls and side walls connecting the major walls to each other. At least one of the major walls has an external surface to which the transducer may... | 01/17/2006 |
| 6950328 | Imprint suppression circuit scheme A ferroelectric memory array includes a plurality of memory pages each formed of a plurality of ferroelectric memory cells. The ferroelectric memory cells are supplied by common word lines. Status memory cells are connected to each of the plurality of memory pages, ... | 09/27/2005 |
| 6942169 | Micromachined lysing device and method for performing cell lysis A method and device for performing lysing on a cell-containing fluid, in which the fluid flows through a vibrating micromachined tube to physically rupture the cell walls (mechanical lysis), and/or to mix, agitate or homogenize the fluid during chemical lysis, and/o... | 09/13/2005 |
| 6887362 | Dielectrophoretic separation and immunoassay methods on active electronic matrix devices This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates generally to bioparticle separation, bioparticle enrichment, and elect... | 05/03/2005 |
| 6878540 | Device for lysing cells, spores, or microorganisms A device for use with an ultrasonic transducer to lyse components of a fluid sample comprises a cartridge having a lysing chamber, an inlet port in fluid communication with the lysing chamber, and an outlet port for exit of the sample from the lysing chamber. The in... | 04/12/2005 |
| 6852851 | DNA isolation method Disclosed is a method and apparatus for the isolation of DNA or cell nuclei or a mixture thereof from cell samples in a CD device. The method includes treating a suspension of whole cells with a lysis reagent so as to lyse the cytoplasmic membrane and at least some ... | 02/08/2005 |
| 6800752 | Chromatography material and a method using the same A chromatography material for separation of nucleic acid mixtures, having a carrier and ion exchanger functions applied to it is described, whereby the carrier comprises a fibrous material. In addition, a method that is performed with the chromatography material acc... | 10/05/2004 |
| 6743624 | Process for continuous purification and concentration of leukocytes from blood Process and apparatus for the continuous purification and concentration of leukocytes from blood, characterized in that said process comprises the following steps: (a) seperating plasma from the blood by filtration in order to achieve a filtered buffy coat fraction;... | 06/01/2004 |
| 6699706 | Cell lysis method using a vortex mixer Cell lysis may be brought about by contacting a suspension of cells with a lysis reagent such as sodium hydroxide solution; subsequent treatment enables organic molecules such as plasmid DNA to be separated from other cell components. Intimate mixing of t... | 03/02/2004 |
| 6699711 | Device and method for selective exposure of a biological sample to sound waves A device and method are disclosed for selective exposure of a biological sample, preferably biological cell material, to sound waves. The device is provided with a receptacle for the sample, in which the biological sample is in a suspended form, and havin... | 03/02/2004 |
| 6686195 | Method and apparatus for ultrasonic lysis of biological cells An apparatus including at least one sonotrode (2) designed to generate ultrasound of variable power in at least one biological sample (5) containing cells to be lysed, the sample (5) being contained in at least one receptacle (4 or 10) such that the sonot... | 02/03/2004 |
| 6632662 | Device and method for the lysis of micro-organisms The invention concerns a device for lysis (1) of micro-organism to release at least one intracellular biological constituent, comprising a container (2) wherein are present a biological sample, in liquid medium, containing the micro-organism to be lyzed, ... | 10/14/2003 |
| 6534295 | Cell lysis device A micromachined cell lysis device with electrodes that are spaced by less than 10 μm from one another. The cells are attracted to the space between the.electrodes and then lysed.... | 03/18/2003 |
| 6495351 | Loading system and method for using the same A loading system for providing a cell suitable for delivery of an agent to a vertebrate, the system comprise a loading module for loading a cell with an agent; and a sensitisation module in fluid communication with the loading module, the sensitisation mo... | 12/17/2002 |
| 6440725 | Integrated fluid manipulation cartridge A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), ... | 08/27/2002 |
| 6409528 | Device and method for collecting, preparation and stabilizing a sample An assembly device and method for collecting and testing fluid samples more specifically for preparing and stabilizing nucleic acid components in a closed system. The assembly comprises a sample collection container with preloaded testing reagents and a s... | 06/25/2002 |
| 6395516 | Vessel for mixing a cell lysate The invention relates to a vessel for mixing a cell lysate. The invention also relates to a method of using the vessel to mix a cell lysate in order to obtain high-purity products such as nucleic acids or proteins for use in a variety of applications. The... | 05/28/2002 |
| 6352838 | Microfluidic DNA sample preparation method and device Manipulation of DNA molecules in solution has become an essential aspect of genetic analyses used for biomedical assays, the identification of hazardous bacterial agents, and in decoding the human genome. Currently, most of the steps involved in preparing... | 03/05/2002 |
| 6344349 | Process and system for electrical extraction of intracellular matter from biological matter A process and system for electrical extraction of intracellular matter from biological matter, and intracellular matter products formed thereby, based on preparing a mixture of biological matter featuring cells, and an electro-conductive liquid, and elect... | 02/05/2002 |
| 6287831 | Cell lysis device A micromachined cell lysis device with electrodes that are spaced less than 100 μm from one another. The cells are attracted to the space between the electrodes and then lysed.... | 09/11/2001 |
| 6280590 | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mixtures such as cel... | 08/28/2001 |
| 6281008 | Nucleic acid extraction apparatus This invention provides an apparatus for extracting nucleic acids from nucleic acid-containing samples. The nucleic acid extraction apparatus of the invention comprises (1) a group of extraction vessels each comprising a reactor tube in which a sample, a ... | 08/28/2001 |
