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| Number | Title | Issue Date |
| 8129179 | Bioreactors with an array of chambers and a common feed line A bioreactor (200) for cultivating living cells in a liquid medium. In one embodiment, the bioreactor (200) has a substrate (230) having a first surface and an opposite second surface, defining a channel (202) therein, and a plurality of ... | 03/06/2012 |
| 8058060 | Culture insert carrier, culture insert and culture insert system The present invention relates to a culture insert carrier, a culture insert and a culture system for culturing and testing of different kinds of cells, such as for example skin models. A culture insert carrier for supporting at least one culture insert in a culture ... | 11/15/2011 |
| 8053230 | Culture dish with lid A device for culturing cells or tissue includes a culture dish with a bottom wall and at least one sidewall to define an interior cavity, at least one channel formed on the bottom wall to minimize the effect of fluid movement on biologics in the dish and, optionally... | 11/08/2011 |
| 8039252 | Multi-chamber cell culture assembly A multi-chamber cell culture assembly has provisions for the distribution of nutrient culture medium and gasses throughout each of the chambers. A device is constructed to provide a large surface area for the growth and cultivation of hybridomas, mammalian and insec... | 10/18/2011 |
| 7977089 | Bioreactors with multiple chambers A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liqu... | 07/12/2011 |
| 7972841 | Exposure device The present invention relates to an exposure device for living cell cultures, the device having a medium chamber common to a plurality of cell culture chambers and medium directing means. The medium chamber, cell culture chambers and the medium directing means may b... | 07/05/2011 |
| 7749750 | Culturing apparatus A culturing apparatus has a culture vessel having a first elastic seal bonded on its upper surface and a culture space formed thereon, and a joint for supplying solution such as a medium to the culture vessel and a second elastic seal having microprojection formed a... | 07/06/2010 |
| 7727759 | Structure for cell culture, cell culture vessel, structure with spheroid, vessel with spheroid, and manufacturing methods thereof By using a microfabrication technique such as nanoimprinting, a structure for cell culture comprising: a concavo-convex structure having a plurality of successive unit structures each formed in a polygonal shape in a planar direction and having a minimum internal di... | 06/01/2010 |
| 7682823 | Bioreactor systems The present invention provides novel bioreactor systems, adapted to provide continuous batch incubation of microbes, especially bacteria. The bioreactor bags are preloaded with dry, inert microbes prior to being shipped to the user. Multiple sterile, preloaded, disp... | 03/23/2010 |
| 7442542 | Shallow multi-well plastic chip for thermal multiplexing Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limitation has been overcome by forming a disposable plastic chip ... | 10/28/2008 |
| 7425440 | Culture flask A culture flask 10 comprises two or more internal chambers 18-21 defining a plurality of parallel surfaces of different sizes and means for fluid communication 24 between the chambers 18-20. ... | 09/16/2008 |
| 7419822 | Microfluidic device for enabling fluidic isolation among interconnected compartments within the apparatus and methods relating to same Embodiments of the invention are directed to a device that combines microfabrication, microfluidic, and surface micropatterning techniques to create a multi-compartment neuronal culturing device that has application across a number of different neuroscience uses. De... | 09/02/2008 |
| 7410804 | Process of parallel sample presentation A process of forming an array of powder samples arranged in predefined locations where all samples have a flat surface in a common plane has been developed. A main support having at least N perforations from a first surface of the main support through a second surfa... | 08/12/2008 |
| 7396673 | Device for measuring extracellular potential A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding dr... | 07/08/2008 |
| 7396677 | Method of preparing nucleic acids for detection A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit con... | 07/08/2008 |
| 7371561 | In vitro, multiple electrode pair array and multiple treatment cell apparatus for use in electroporation A multiple electrode pair array apparatus is provided for use with a multiple well plate which has multiple wells distributed in a two-dimensional matrix array which has R rows and C columns. The multiple electrode pair array apparatus includes a non-conductive base... | 05/13/2008 |
| 7364897 | Methods and devices for performing chemical reactions on a solid support Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top o... | 04/29/2008 |
| 7329537 | Micro-pattern embedded plastic optical film device for cell-based assays In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and curves, and numbers and letters. Furthermore, the optical film contains a ... | 02/12/2008 |
| 7329392 | Device and method for handling reaction components An apparatus and method for performing successive chemical or biochemical operations in an automated or semi-automated format are disclosed. The apparatus includes (i) a substrate having two or more wells, where each well is separated from adjacent well(s) by an ene... | 02/12/2008 |
| 7294367 | Biological laser printing via indirect photon-biomaterial interactions A method of laser forward transfer is disclosed. Photon energy is directed through a photon-transparent support and absorbed by an interlayer coated thereon. The energized interlayer causes the transfer of a biological material coated thereon across a gap and onto a... | 11/13/2007 |
| 7276216 | Protein crystallography prescreen kit A kit for prescreening protein concentration for crystallization includes a multiplicity of vials, a multiplicity of pre-selected reagents, and a multiplicity of sample plates. The reagents and a corresponding multiplicity of samples of the protein in solutions of v... | 10/02/2007 |
| 7258799 | Method and apparatus for magnetic separation of particles A magnetic circuit is shaped to generate an essentially uniform magnetic field parallel across the length of a container, and an essentially uniform magnetic field gradient along the length of the container as well. The dot product of the magnetic field and magnetic... | 08/21/2007 |
| 7244913 | Temperature regulator for microchemical chip A temperature regulator regulates a temperature of a microchemical chip that has chemical reaction sections. The temperature regulator includes a temperature measuring unit and a thermoelectric element corresponding to each chemical reaction section. The temperature... | 07/17/2007 |
| 7241616 | System for culturing human cells and tissues Disclosed is a human cell/tissue culturing system including a plurality of incubators, each incubator capable of aseptically storing/culturing cell(s) or tissue(s) derived from a (human) individual and identifying the cell(s) or the tissue(s) during incubation, wher... | 07/10/2007 |
| 7235400 | Laminated microarray interface device A device for forming a low volume reaction chamber on a substrate such as a microarray slide and its method of use is disclosed. The reaction chamber forming device has an adhesive laminate design that permits it to be manufactured as a disposable device. A preferre... | 06/26/2007 |
| 7223363 | Method and system for microfluidic interfacing to arrays A method and system for providing a fluidic interface to slides bearing microarrays of biomolecules or other samples immobilized thereon to perform a variety of chemical reactions or processing steps on the slide. An interface device seals against the slide to form ... | 05/29/2007 |
| 7219800 | Modular array arrangements The present invention pertains to modular array arrangements comprising a carrier and at least one insert for attachment to said carrier, which at least one insert may be positioned in or on said carrier in a predetermined, fixed orientation. In addition, the presen... | 05/22/2007 |
| 7198896 | Immunoaffinity isolation of modified peptides from complex mixtures The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more d... | 04/03/2007 |
| 7189526 | Apparatus for culture, process for preparing apparatus for culture, and culturing method An apparatus for culture is provided, which apparatus enables to increase the ratio of a culture medium solution to the number of cells while keeping the density of the cells at a high level and diminishing the absolute number of the cells. The apparatus comprises a... | 03/13/2007 |
| 7190449 | Cell tray A cell tray has a multi-dimensional array of cells in precise, equally spaced wells (cubicles or silos) containing medium of interest. The ordered cell array enables automated processing as well as simultaneous monitoring and analyzing of a large matrix of cells, bi... | 03/13/2007 |
| 7186548 | Cell culture tool and method A cell co-culture tool includes a body, an outer wall surrounding the body, and more than one vessel within the perimeter of the outer wall. Each vessel has a top edge below a rim of the outer wall. A method of interacting a substance with more than one type ... | 03/06/2007 |
| 7169577 | Cell isolation and screening device and method of using same The present invention provides methods and devices for screening a single cell or a small group of cells for a desired biological activity. In particular, the present invention provides for delivering cell(s) to a plurality of cell isolation regions of a cell isolat... | 01/30/2007 |
| 7160717 | LED array for illuminating cell well plates and automated rack system for handling the same An assembly for promoting the growth of plant tissues that includes a plurality of plates each defining an array of wells wherein each of the wells contains a tissue sample. Support for the plates is provided by a rack having a plurality of vertically stacked shelve... | 01/09/2007 |
| 7121998 | Vented microcradle for prenidial incubator A vented microcradle comprising a microfabricated enclosure designed to maintain a human embryo or hatching in a controlled care environment, the enclosure forming a cradle support for the human embryo or hatchling and having a ventilation system to provide the huma... | 10/17/2006 |
| 7122338 | Method for quantification of biological material in a sample Methods for the detection and/or quantification of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation vessel. The incubation vessel has a generally flat horizo... | 10/17/2006 |
| 7081600 | Method and apparatus for cover assembly for thermal cycling of samples A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element ar... | 07/25/2006 |
| 7063979 | Interface between substrates having microarrays and microtiter plates The invention describes a process for preparing a microtiter-microarray device that includes a bottomless microtiter plate attached to the first side of one or more substrates with microarrays of materials attached thereto. The microtiter plate and the one or more s... | 06/20/2006 |
| 7048893 | Mask for depositing and distributing reagents on an analytical support The invention concerns a mask for distributing reagents on an analytical support, such as an electrophoresis gel, the mask having a body with parallel upper and lower surfaces, a plurality of lanes located on the lower surface of the mask have wedge-shaped projectin... | 05/23/2006 |
| 7033821 | Device for monitoring cell motility in real-time The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to... | 04/25/2006 |
| 7029907 | Cell culture incubating apparatus and method using the same A cell incubating apparatus and a method of culturing cells in vitro are disclosed, which relates to medical cell proliferation, pharmaceutical chemical screening and automatic cell analysis in tissue engineering technology. The apparatus establishes an imitating th... | 04/18/2006 |
