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| Number | Title | Issue Date |
| 7910360 | Device and method for uniformly inoculating a substrate having three-dimensional surfaces An apparatus and method for inoculating a biological substrate with cells include provision for rotating a container in which the substrate and a cell suspension are received about first and second axes of rotation. The apparatus comprises said container, first driv... | 03/22/2011 |
| 7371566 | Composting apparatus and method A composting apparatus including an electric motor driven drum. The drum is provided with spaced fins on the inner surface and a supporting shaft that can include air holes to provide air within the confines of the drum. In this instance, tubes with holes are secure... | 05/13/2008 |
| 7358082 | Device and method for culturing cells An object of the present invention is to construct a culture device optimized for culturing animal cells. The present invention provides a device for culturing cells which comprises at least one water-containing polymer gel film for adhering animal cells onto at lea... | 04/15/2008 |
| 7354748 | Method for treating osteoarthritis and other diseases, defects and injuries of the knee joint A method for applying therapeutic electrical signals and/or electromagnetic fields to a patient's knee for the treatment of osteoarthritis and other diseases, defects and injuries. The device that is used is operable in several modes to deliver signals to the patien... | 04/08/2008 |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7326564 | Flow system for medical device evaluation and production In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit along with the medical device mount to induce relative motion of the f... | 02/05/2008 |
| 7300789 | Bioreactor forming a rigid vessel The invention provides a bioreactor (10) for the culture of animal, vegetable, microbial of algal cells of their co-cultures, of the type including a body (12) which delimits an internal volume (14) capable of holding a culture liquid (16) and a gas volume (17) abov... | 11/27/2007 |
| 7215995 | Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip A method of determining the voltage and current required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used ... | 05/08/2007 |
| 7202055 | Process for the production of proteins and the production of arrays of proteins Described is a novel process for the production of at least one protein of interest by secretion of the protein of interest from a pro- or eukaryotic host cell in a compartment system, which host cell is stably expressing a secretion system and capable of heterologo... | 04/10/2007 |
| 7198940 | Bioreactor apparatus and cell culturing system A bioreactor apparatus and cell culturing system is provided for the automated cultivation and processing of living cells remotely both on earth and in low gravity which utilizes a generally cylindrical reactor vessel that may be optionally rotated about its cylindr... | 04/03/2007 |
| 7189281 | Method and system for treating contaminants and odors in airborne emissions A second-generation rotating biofilter employing microorganisms in a microbiological film (biofilm) “mineralizes” contaminants, such as VOCs and odoriferous contaminants. Contaminated fluid, such as air from manufacturing processes, is directed radially outward ... | 03/13/2007 |
| 7186549 | Container for shipping items in aircraft A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas t... | 03/06/2007 |
| 7167753 | Device and method for electrically inducing osteogenesis in the spine A technique and associated device for stimulating multiple electrodes with multiple electrical signals in multiple regions of the spine without injury to the patient. The electrodes are applied to respective sides of the patient's spine, and a first electrical signa... | 01/23/2007 |
| 7144727 | Interlinked culture chamber for biologicals The bioreactor system of the present invention has two fluid-filled culture compartments in which cells, tissues and other biologicals are cultured. The two culture compartments are in fluid communication with each other and each culture compartment is transversed b... | 12/05/2006 |
| 7067307 | Bioartificial device for the storage, cultivation and/or multiplication of cells The bioartificial reactor has a reactor vessel. A cell culture chamber in the reactor, in particular for liver cells, is divided off from a flow chamber for a nutritive medium and from a flow chamber for plasma and blood by semipermeable walls. At least one flow cha... | 06/27/2006 |
| 6948844 | Olive stuffing method and apparatus Apparatus for stuffing pitted olives with an edible filling features a drum and drum holder, plus drive means for rotating the drum holder and drum about a selected rotational axis. Pitted olives are placed in a drum along with a quantity of filling, then the drum i... | 09/27/2005 |
| 6919205 | Regulation of type II collagen gene expression using specific and selective electrical and electromagnetic signals Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articu... | 07/19/2005 |
| 6867040 | Bioreactor and methods for producing synchronous cells Apparatus and methods are directed to a perfusion culture system in which a rotating bioreactor is used to grow cells in a liquid culture medium, while these cells are attached to an adhesive-treated porous surface. As a result of this arrangement and its rotation, ... | 03/15/2005 |
| 6841384 | Advanced roller bottle system for cell and tissue culturing The invention provides an advanced roller bottle system for cell culture that efficiently, continually, and automatically replenishes spent media with fresh media. The roller bottle system optimizes media use by removing spent media in response to a predetermined co... | 01/11/2005 |
| 6780638 | Cell culture apparatus A cell culture apparatus comprises a rotor releasably housing a plurality of cell culture vessels/roller bottles. The apparatus provides for rotation of the rotor at a controlled speed about a substantially horizontal axis and for the rotational axis of the rotor an... | 08/24/2004 |
| 6720178 | Self-feeding roller bottle A reservoir is provided with a spiroid pump which enables the automatic transfer of fresh medium into a roller bottle culture chamber. The reservoir may be formed from a portion of a culture chamber or may be a separate bottle. ... | 04/13/2004 |
| 6699706 | Cell lysis method using a vortex mixer Cell lysis may be brought about by contacting a suspension of cells with a lysis reagent such as sodium hydroxide solution; subsequent treatment enables organic molecules such as plasmid DNA to be separated from other cell components. Intimate mixing of t... | 03/02/2004 |
| 6673598 | Disposable culture bag A cell culture bag for culturing cells, cellular aggregates, particles, tissues and organoids is disclosed. The cell culture bag is a flexible and disposable culture bag that fits within a bag support chamber of a bioreactor. The cell culture bag has an i... | 01/06/2004 |
| 6673597 | Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof The present invention provides systems for growing two or three dimensional mammalian cells within a culture medium facilitated by an electromagnetic field, and preferably, a time varying electromagnetic field. The cells and culture medium are contained w... | 01/06/2004 |
| 6642019 | Vessel, preferably spherical or oblate spherical for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same An improved culture vessel or bioreactor for growing cells, cellular aggregates, tissue particles or tissue "organoids" and methods for using same which includes a housing having at least one chamber defined by a curved wall symmetrical about an axis. The... | 11/04/2003 |
| 6607910 | Two chamber cell culture vessel A two-chamber perfusion bioreactor counteracts a significant amount of shear stress while allowing high nutrient transfer and removal of waste and/or valuable bio-products, e.g., protein, hormones, growth factors, and monoclonal antibodies without disturb... | 08/19/2003 |
| 6605463 | Rolling mount for a reactor The invention relates to a mount for a container, e.g., a cell culture flask or a reactor with supply connections, for instance a bioreactor, that is chiefly designed for treatment in a rolling cabinet or in a chamber having rolling devices. The device ha... | 08/12/2003 |
| 6500666 | Hybridization oven/incubator rotisserie and bottle retainer system The invention relates to a hybridization oven or incubator, and more particularly to a rotisserie and carousel/retainer system for use therein. The rotisserie includes a spindle that is readily removable from the oven, having a first end received in an an... | 12/31/2002 |
| 6492163 | Cell culture tube and multiple roller tube cell culture system using the same A cell tube for ex vivo culturing animal cells and a multiple roller tube cell culture system are disclosed. Suitable for use in culturing cells, the tube has at its opposite end walls two openings through which culture media can come in and out. The open... | 12/10/2002 |
| 6485963 | Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof The present invention provides systems for growing two or three dimensional mammalian cells within a culture medium facilitated by an electromagnetic field, and preferably, a time varying electromagnetic field. The cells and culture medium are contained w... | 11/26/2002 |
| 6399363 | Method of permeant removal from cell suspension in a porous container An apparatus in which cryoprotectant in cryopreserved samples is removed with the use of turbulence and convective-dispersion around the cells within the primary cryopreservation container. Convective-dispersion is applied via the combined action of gravi... | 06/04/2002 |
| 6329196 | Methods and apparatus for enhancement of mass transfer of a fluid in a porous matrix system containing biomass A biological process is enhanced by a method and apparatus used to contact a biomass with a gas and with a nutrient liquid. A resiliently compressible porous matrix system containing the biomass is mounted in a reaction vessel containing a body of the nut... | 12/11/2001 |
| 6251653 | Method of improved mixing of a varicella-infected cell culture in roller bottles A method for enhancing the mixing of a varicella-infected cell culture in a roller bottle by the introduction of controlled cross-sectional flow perturbations in roller bottle rotation is disclosed. The effectiveness of the method is demonstrated by achie... | 06/26/2001 |
| 6150159 | Cell culture vessel A cell culture vessel formed generally about an elongate axis and being provided with a neck and a removable closure member, and at a distal end thereof an end closure portion; said vessel being adapted for tissue culture growth and formed of a sterilizab... | 11/21/2000 |
| 6071727 | Production of microbial cellulose A microbial cellulose with high water content and process for making the microbial cellulose utilizes a rotary disk or linear conveyor bioreactor containing a biological medium and a cellulose producing microorganism are provided.... | 06/06/2000 |
| 6066497 | Cell culture apparatus A cell culture apparatus is disclosed. The cell culture apparatus includes a chassis or supporting frame. The cell culture apparatus also includes a rotor releasably housing a plurality of cell culture vessels/roller bottles, the rotor being mounted about... | 05/23/2000 |
| 6022733 | Simulated biological dissolution and absorption system The invention relates to a system and method for assessing simulated biological dissolution of a pharmaceutical formulation and absorption of a pharmaceutically active compound therefrom. The system comprises a dissolution chamber and a cell culture chamb... | 02/08/2000 |
| 6001643 | Controlled hydrodynamic cell culture environment for three dimensional tissue growth A novel hydrodynamic cell culture environment is disclosed for a two-chamber roller bottle. The unstable hydrodynamics of a gas headspace media chamber is coupled through a center opening to a second zero headspace culture chamber. Coupling the two chambe... | 12/14/1999 |
| 6001642 | Bioreactor and cell culturing processes using the bioreactor A bioreactor and cell culturing method using the bioreactor have been developed to enhance cell production and growth and decrease the shear forces on the cells and multicellular aggregates. The bioreactor contains a dome-shaped culture vessel having wall... | 12/14/1999 |
| 5998202 | Multiple chamber diffusion vessel A bioreactor system features a vessel capable of being temperature controlled comprised of two or more cylindrical chambers separated by a common porous membrane. The chambers are capable of being mounted for rotation about a common horizontal axis, essen... | 12/07/1999 |
